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Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase

The Journal of biological chemistry, 2015-07, Vol.290 (29), p.18124-18133

2015

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The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Nature communications, 2017-01, Vol.8 (1), p.13944-13944, Article 13944

2017

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Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release

Journal of Immunology Research, 2018, Vol.2018 (2018), p.1-9

2018

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Cyanidin-3-glucoside Alleviates 4-Hydroxyhexenal-Induced NLRP3 Inflammasome Activation via JNK-c-Jun/AP-1 Pathway in Human Retinal Pigment Epithelial Cells

Journal of Immunology Research, 2018-01, Vol.2018 (2018), p.1-8

2018

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F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation

Nature immunology, 2012-07, Vol.13 (7), p.651-658

2012

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A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

Nature immunology, 2013-05, Vol.14 (5), p.470-479

2013

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Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Nature communications, 2017-05, Vol.8 (1), p.15203-13, Article 15203

2017

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Natural Products as Targeted Modulators of the Immune System

Journal of immunology research, 2018-01, Vol.2018, p.7862782-2

2018

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The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin

The Journal of biological chemistry, 2015-05, Vol.290 (19), p.11843-11852

2015

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CD4 + T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1-Dependent

American journal of respiratory and critical care medicine, 2022-06, Vol.205 (12), p.1403-1418

2022

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Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses

Nature communications, 2024-07, Vol.15 (1), p.6172-16, Article 6172

2024

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Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome

Critical care medicine, 2019-12, Vol.47 (12), p.1724-1734

2019

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Therapeutic targets in fibrotic pathways

Cytokine (Philadelphia, Pa.), 2016-12, Vol.88, p.193-195

2016

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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

The Journal of biological chemistry, 2019-11, Vol.294 (45), p.16527-16534

2019

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IL-10 Is Critical for Regulation of Cytotoxic CD4+NKG7+ T Cells in Lung Allograft Rejection but Is Not Required for Allograft Acceptance

The Journal of immunology (1950), 2024-09, Vol.213 (6), p.898-905

2024

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Toll-like Receptor 8 Stability Is Regulated by Ring Finger 216 in Response to Circulating MicroRNAs

American journal of respiratory cell and molecular biology, 2020-02, Vol.62 (2), p.157-167

2020

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F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation

Blood, 2012-03, Vol.119 (13), p.3132-3141

2012

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Discovery of bactericides as an acute mitochondrial membrane damage inducer

Molecular biology of the cell, 2021-11, Vol.32 (21), p.ar32-ar32

2021

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Post-translational modification of the interferon-gamma receptor alters its stability and signaling

Biochemical journal, 2017-10, Vol.474 (20), p.3543-3557

2017

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E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro

The Journal of biological chemistry, 2023-12, Vol.299 (12), p.105388-105388, Article 105388

2023

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A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells

Frontiers in pharmacology, 2022-01, Vol.13, p.828643, Article 828643

2022

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A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

Nature chemical biology, 2021-03, Vol.17 (3), p.298-306

2021

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A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

Redox biology, 2020-05, Vol.32, p.101485, Article 101485

2020

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KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation

The FEBS journal, 2023-08, Vol.290 (15), p.3802-3811

2023

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Modulation of lysosomal function as a therapeutic approach for coronaviral infections

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release

Cyanidin-3-glucoside Alleviates 4-Hydroxyhexenal-Induced NLRP3 Inflammasome Activation via JNK-c-Jun/AP-1 Pathway in Human Retinal Pigment Epithelial Cells

F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Natural Products as Targeted Modulators of the Immune System

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin

CD4 + T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1-Dependent

Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses

Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome

Therapeutic targets in fibrotic pathways

The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

IL-10 Is Critical for Regulation of Cytotoxic CD4+NKG7+ T Cells in Lung Allograft Rejection but Is Not Required for Allograft Acceptance

Toll-like Receptor 8 Stability Is Regulated by Ring Finger 216 in Response to Circulating MicroRNAs

F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation

Discovery of bactericides as an acute mitochondrial membrane damage inducer

Post-translational modification of the interferon-gamma receptor alters its stability and signaling

E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro

A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells

A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation

Modulation of lysosomal function as a therapeutic approach for coronaviral infections

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