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The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies

Neuropharmacology, 2020-08, Vol.172, p.107839-107839, Article 107839

2020

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A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility

Cell, 2022-09, Vol.185 (18), p.3390-3407.e18

2022

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Spatiotemporal dynamics of 5-HT6 receptor ciliary localization during mouse brain development

Neurobiology of disease, 2023-01, Vol.176, p.105949-105949, Article 105949

2023

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Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5‑HT3 and 5‑HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13279-13298

2021

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Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

EMBO molecular medicine, 2020-05, Vol.12 (5), p.e10605-n/a

2020

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The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism

Development (Cambridge), 2014-09, Vol.141 (17), p.3370-3377

2014

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Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

EMBO molecular medicine, 2022-09, Vol.14 (9), p.e16481-n/a

2022

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The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication

Nature communications, 2020-09, Vol.11 (1), p.1-14, Article 4855

2020

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5‑HT6 Receptor: A New Player Controlling the Development of Neural Circuits

ACS chemical neuroscience, 2015-07, Vol.6 (7), p.951-960

2015

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5‐HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

EMBO molecular medicine, 2012-10, Vol.4 (10), p.1043-1056

2012

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Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT6 and D3R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series

Molecules (Basel, Switzerland), 2023-01, Vol.28 (3), p.1096

2023

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2‑Phenyl‑1H‑pyrrole-3-carboxamide as a New Scaffold for Developing 5‑HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity

ACS chemical neuroscience, 2021-04, Vol.12 (7), p.1228-1240

2021

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Impact of 5-HT6 Receptor Subcellular Localization on Its Signaling and Its Pathophysiological Roles

Cells (Basel, Switzerland), 2023-01, Vol.12 (3), p.426

2023

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1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

Biomolecules (Basel, Switzerland), 2023-01, Vol.13 (1), p.12

2023

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Angiogenin induces modifications in the astrocyte secretome: Relevance to amyotrophic lateral sclerosis

Journal of proteomics, 2013-10, Vol.91, p.274-285

2013

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Physical interaction between neurofibromin and serotonin 5-HT₆ receptor promotes receptor constitutive activity

Proceedings of the National Academy of Sciences - PNAS, 2016-10, Vol.113 (43), p.12310-12315

2016

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Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth

Nature chemical biology, 2014-07, Vol.10 (7), p.590

2014

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mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Progress in neurobiology, 2020-10, Vol.193, p.101846-101846, Article 101846

2020

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Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes

Handbook of Behavioral Neuroscience, 2020, Vol.31, p.91-120

2020

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5-HT6 receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives

European journal of medicinal chemistry, 2024-09, Vol.275, p.116615, Article 116615

2024

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Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor

Progress in neurobiology, 2021-02, Vol.197, p.101900, Article 101900

2021

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Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties

European journal of medicinal chemistry, 2018-01, Vol.144, p.716-729

2018

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Novel 1H‑Pyrrolo[3,2‑c]quinoline Based 5‑HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer’s Disease

ACS chemical neuroscience, 2016-07, Vol.7 (7), p.972-983

2016

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Early 5-HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

EMBO molecular medicine, 2020-05, Vol.12 (5), p.e10605

2020

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The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies

A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility

Spatiotemporal dynamics of 5-HT6 receptor ciliary localization during mouse brain development

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5‑HT3 and 5‑HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties

Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

Superiority of the Triple-Acting 5‑HT6R/5-HT3R Antagonist and MAO‑B Reversible Inhibitor PZ-1922 over 5‑HT6R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats

The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism

Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication

5‑HT6 Receptor: A New Player Controlling the Development of Neural Circuits

5‐HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT6 and D3R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series

2‑Phenyl‑1H‑pyrrole-3-carboxamide as a New Scaffold for Developing 5‑HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity

Impact of 5-HT6 Receptor Subcellular Localization on Its Signaling and Its Pathophysiological Roles

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

Angiogenin induces modifications in the astrocyte secretome: Relevance to amyotrophic lateral sclerosis

Physical interaction between neurofibromin and serotonin 5-HT₆ receptor promotes receptor constitutive activity

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth

mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes

5-HT6 receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives

Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor

Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties

Novel 1H‑Pyrrolo[3,2‑c]quinoline Based 5‑HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer’s Disease

Early 5-HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

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