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NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

Clinical cancer research, 2016-02, Vol.22 (3), p.680-690

2016

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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

PloS one, 2017-07, Vol.12 (7), p.e0179431

2017

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Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist

Nature communications, 2020-01, Vol.11 (1), p.660-660, Article 660

2020

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A platform technology for ultra-long acting intratumoral therapy

Scientific reports, 2024-06, Vol.14 (1), p.14000-11

2024

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Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice

Journal for immunotherapy of cancer, 2021-06, Vol.9 (6), p.e002715

2021

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NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8+ T cell responses capable of curing multi-focal cancer

Journal for immunotherapy of cancer, 2020-05, Vol.8 (1), p.e000464

2020

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Color and Chromism of Polydiacetylene Vesicles

Accounts of chemical research, 1998-05, Vol.31 (5), p.229-239

1998

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Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion

Journal for immunotherapy of cancer, 2021-11, Vol.9 (11), p.e003480

2021

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Reversible Color Switching and Unusual Solution Polymerization of Hydrazide-Modified Diacetylene Lipids

Journal of the American Chemical Society, 1999-05, Vol.121 (19), p.4580-4588

1999

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Abstract 558: Durable antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 combined with immune checkpoint blockade

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.558-558

2016

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Chain Length Dependence of the Frictional Properties of Alkylsilane Molecules Self-Assembled on Mica Studied by Atomic Force Microscopy

Langmuir, 1996-01, Vol.12 (2), p.235-237

1996

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Design and Synthesis of Novel Glycopolythiophene Assemblies for Colorimetric Detection of Influenza Virus and E. coli

Bioconjugate chemistry, 2000-11, Vol.11 (6), p.777-788

2000

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Direct Colorimetric Detection of a Receptor-Ligand Interaction by a Polymerized Bilayer Assembly

Science (American Association for the Advancement of Science), 1993-07, Vol.261 (5121), p.585-588

1993

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Molecular Recognition and Colorimetric Detection of Cholera Toxin by Poly(diacetylene) Liposomes Incorporating Gm1 Ganglioside

Langmuir, 1997-03, Vol.13 (6), p.1365-1367

1997

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Incorporation of Unprotected Heterocyclic Side Chains into Peptoid Oligomers via Solid-Phase Submonomer Synthesis

Journal of the American Chemical Society, 2003-07, Vol.125 (29), p.8841-8845

2003

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Induced Color Change of Conjugated Polymeric Vesicles by Interfacial Catalysis of Phospholipase A2

Angewandte Chemie International Edition, 1999-03, Vol.38 (5), p.655-659

1999

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Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells

Journal of cellular biochemistry, 2008-06, Vol.104 (3), p.1075-1086

2008

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Molecular Imaging of Thermochromic Carbohydrate-Modified Polydiacetylene Thin Films

Langmuir, 1997-11, Vol.13 (24), p.6524-6532

1997

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Application of (3-mercaptopropyl)trimethoxysilane as a molecular adhesive in the fabrication of vapor-deposited gold electrodes on glass substrates

Analytical chemistry (Washington), 1991-01, Vol.63 (1), p.85-88

1991

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Total Alignment of Calcite at Acidic Polydiacetylene Films: Cooperativity at the Organic-Inorganic Interface

Science (American Association for the Advancement of Science), 1995-07, Vol.269 (5223), p.515-518

1995

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Preparation, Structure, and Mechanical Stability of Alkylsilane Monolayers on Mica

Langmuir, 1995-05, Vol.11 (5), p.1600-1604

1995

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Solid Phase Immobilization of Optically Responsive Liposomes in Sol-Gel Materials for Chemical and Biological Sensing

Langmuir, 1997-09, Vol.13 (19), p.5049-5053

1997

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Carbohydrates in an Acidic Multivalent Assembly: Nanomolar P-Selectin Inhibitors

Journal of medicinal chemistry, 1996-03, Vol.39 (5), p.1018-1020

1996

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Efficacy and immune modulation by BXCL701 a dipeptidyl peptidase inhibitor, NKTR-214 a CD122-biased immune agonist with PD1 blockade in murine pancreatic tumors

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.3085-3085

2018

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Efficacy and immune modulation of the tumor microenvironment with the combination of the PARP inhibitor rucaparib and CD122-biased agonist NKTR-214

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.5582-5582

2018

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NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist

A platform technology for ultra-long acting intratumoral therapy

Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice

NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8+ T cell responses capable of curing multi-focal cancer

Color and Chromism of Polydiacetylene Vesicles

Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion

Reversible Color Switching and Unusual Solution Polymerization of Hydrazide-Modified Diacetylene Lipids

Abstract 558: Durable antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 combined with immune checkpoint blockade

Chain Length Dependence of the Frictional Properties of Alkylsilane Molecules Self-Assembled on Mica Studied by Atomic Force Microscopy

Design and Synthesis of Novel Glycopolythiophene Assemblies for Colorimetric Detection of Influenza Virus and E. coli

Direct Colorimetric Detection of a Receptor-Ligand Interaction by a Polymerized Bilayer Assembly

Molecular Recognition and Colorimetric Detection of Cholera Toxin by Poly(diacetylene) Liposomes Incorporating Gm1 Ganglioside

Incorporation of Unprotected Heterocyclic Side Chains into Peptoid Oligomers via Solid-Phase Submonomer Synthesis

Induced Color Change of Conjugated Polymeric Vesicles by Interfacial Catalysis of Phospholipase A2

Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells

Molecular Imaging of Thermochromic Carbohydrate-Modified Polydiacetylene Thin Films

Application of (3-mercaptopropyl)trimethoxysilane as a molecular adhesive in the fabrication of vapor-deposited gold electrodes on glass substrates

Total Alignment of Calcite at Acidic Polydiacetylene Films: Cooperativity at the Organic-Inorganic Interface

Preparation, Structure, and Mechanical Stability of Alkylsilane Monolayers on Mica

Solid Phase Immobilization of Optically Responsive Liposomes in Sol-Gel Materials for Chemical and Biological Sensing

Carbohydrates in an Acidic Multivalent Assembly: Nanomolar P-Selectin Inhibitors

Efficacy and immune modulation by BXCL701 a dipeptidyl peptidase inhibitor, NKTR-214 a CD122-biased immune agonist with PD1 blockade in murine pancreatic tumors

Efficacy and immune modulation of the tumor microenvironment with the combination of the PARP inhibitor rucaparib and CD122-biased agonist NKTR-214

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