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Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.9897-9919

2013

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Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4672-4684

2008

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Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1690-1694

2012

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Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (7), p.1820-1824

2014

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

Nature medicine, 1995-08, Vol.1 (8), p.792-797

1995

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Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4591-4596

2013

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3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1382-1384

2011

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Discovery of Disubstituted Imidazo[4,5‑b]pyridines and Purines as Potent TrkA Inhibitors

ACS medicinal chemistry letters, 2012-09, Vol.3 (9), p.705-709

2012

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Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.697-700

2009

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3-Amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.701-705

2009

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Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer

Bioorganic & medicinal chemistry letters, 2008-09, Vol.18 (17), p.4794-4797

2008

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A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

Molecular and Cellular Biology, 1998-01, Vol.18 (1), p.85-92

1998

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Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

Biochemistry (Easton), 1993-05, Vol.32 (19), p.5167-5176

1993

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Farnesyltransferase inhibitors versus Ras inhibitors

Current opinion in chemical biology, 1997-08, Vol.1 (2), p.197-203

1997

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Photoreactive Analogues of Prenyl Diphosphates as Inhibitors and Probes of Human Protein Farnesyltransferase and Geranylgeranyltransferase Type I

The Journal of biological chemistry, 1995-08, Vol.270 (32), p.19035-19040

1995

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Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway

Biochemistry (Easton), 1993-08, Vol.32 (32), p.8341-8347

1993

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On the Stereochemical Course of Human Protein-Farnesyl Transferase

Journal of the American Chemical Society, 1996-02, Vol.118 (8), p.1817-1823

1996

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Selection of Potent Inhibitors of Farnesyl-protein Transferase from a Synthetic Tetrapeptide Combinatorial Library

The Journal of biological chemistry, 1996-12, Vol.271 (49), p.31306-31311

1996

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Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Cancer research (Chicago, Ill.), 2001-12, Vol.61 (24), p.8758-8768

2001

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Ferredoxins from two sulfonylurea herbicide monooxygenase systems in Streptomyces griseolus

Biochemistry (Easton), 1991-01, Vol.30 (2), p.447-455

1991

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Identification of Tcf4 Residues Involved in High-Affinity β-Catenin Binding

Biochemical and biophysical research communications, 1999-03, Vol.256 (3), p.584-590

1999

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CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents

Trends in pharmacological sciences (Regular ed.), 1997-11, Vol.18 (11), p.437-445

1997

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Involvement of Directly Repeated Sequences in the Generation of Deletions of the Avian Sarcoma Virus src Gene

Journal of Virology, 1983-08, Vol.47 (2), p.380-382

1983

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cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I

The Journal of biological chemistry, 1994-02, Vol.269 (5), p.3175-3180

1994

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Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

Discovery of Disubstituted Imidazo[4,5‑b]pyridines and Purines as Potent TrkA Inhibitors

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

3-Amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile

Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

Farnesyltransferase inhibitors versus Ras inhibitors

Photoreactive Analogues of Prenyl Diphosphates as Inhibitors and Probes of Human Protein Farnesyltransferase and Geranylgeranyltransferase Type I

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway

On the Stereochemical Course of Human Protein-Farnesyl Transferase

Selection of Potent Inhibitors of Farnesyl-protein Transferase from a Synthetic Tetrapeptide Combinatorial Library

Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Ferredoxins from two sulfonylurea herbicide monooxygenase systems in Streptomyces griseolus

Identification of Tcf4 Residues Involved in High-Affinity β-Catenin Binding

CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents

Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency

Involvement of Directly Repeated Sequences in the Generation of Deletions of the Avian Sarcoma Virus src Gene

cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I

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