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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.E2724-E2732

2013

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The Effect on the Fetus of Medications Used to Treat Pregnant Inflammatory Bowel-Disease Patients

The American journal of gastroenterology, 2004-04, Vol.99 (4), p.656-661

2004

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The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels

Molecular pharmacology, 2016-11, Vol.90 (5), p.540-548

2016

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Recent progress in sodium channel modulators for pain

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3690-3699

2014

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A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability

British journal of pharmacology, 2015-05, Vol.172 (10), p.2654-2670

2015

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Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7029-7042

2017

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Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

ACS medicinal chemistry letters, 2021-04, Vol.12 (4), p.593-602

2021

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Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

Bioorganic & medicinal chemistry, 2008-06, Vol.16 (12), p.6379-6386

2008

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Discovery of the First Orally Available, Selective K Na 1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

ACS medicinal chemistry letters, 2021-04, Vol.12 (4), p.593-602

2021

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GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity

The Journal of physiology, 2001-01, Vol.530 (1), p.21-33

2001

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A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

Neuropharmacology, 2010-09, Vol.59 (3), p.201-207

2010

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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7029-7042

2017

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K channel subconductance levels result from heteromeric pore conformations

The Journal of general physiology, 2005-08, Vol.126 (2), p.87-103

2005

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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain

Bioorganic & medicinal chemistry, 2010-11, Vol.18 (22), p.7816-7825

2010

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Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6812-6815

2010

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Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6812-6815

2010

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The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory Neurons

Anesthesia and analgesia, 2009-08, Vol.109 (2), p.632-640

2009

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Erratum to “The influence of crank configuration on muscle activity and torque production during arm crank ergometry” [J. Electromyogr. Kines. 18 (2008) 598–605]

Journal of electromyography and kinesiology, 2009-06, Vol.19 (3), p.542-542

2009

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1047 Chromoendoscopy Is Superior to Standard Surveillance Techniques for Both High and Low Risk Patients for the Detection of Dysplasia: Analysis of a Prospective Controlled Trial

Gastroenterology (New York, N.Y. 1943), 2009, Vol.136 (5), p.A-160-A-160

2009

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The Selective Na v 1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Na v 1.7 Channels

Molecular pharmacology, 2016-11, Vol.90 (5), p.540-548

2016

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Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel

Pflügers Archiv, 2006-03, Vol.451 (6), p.776-792

2006

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Identification of Novel Pore Interactions for Selective Nav1.8 Inhibitors

Biophysical journal, 2016-02, Vol.110 (3), p.112a-113a

2016

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198 Follow-Up Chromoendoscopy Continues to Be Superior to Standard Colonoscopic Surveillance for Managing Dysplasia in Patients with IBD: A Long-Term, Prospective, Endoscopic Trial

Gastroenterology (New York, N.Y. 1943), 2008, Vol.134 (4), p.A-34-A-34

2008

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Development of High throughput Electrophysiology Assays of Recombinant Nav1.9 Channels

Biophysical journal, 2018-02, Vol.114 (3), p.634a-634a

2018

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

The Effect on the Fetus of Medications Used to Treat Pregnant Inflammatory Bowel-Disease Patients

The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels

Recent progress in sodium channel modulators for pain

A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability

Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

Discovery of the First Orally Available, Selective K Na 1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity

A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7

K channel subconductance levels result from heteromeric pore conformations

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain

Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives

Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory Neurons

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Erratum to “The influence of crank configuration on muscle activity and torque production during arm crank ergometry” [J. Electromyogr. Kines. 18 (2008) 598–605]

1047 Chromoendoscopy Is Superior to Standard Surveillance Techniques for Both High and Low Risk Patients for the Detection of Dysplasia: Analysis of a Prospective Controlled Trial

The Selective Na v 1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Na v 1.7 Channels

Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel

Identification of Novel Pore Interactions for Selective Nav1.8 Inhibitors

198 Follow-Up Chromoendoscopy Continues to Be Superior to Standard Colonoscopic Surveillance for Managing Dysplasia in Patients with IBD: A Long-Term, Prospective, Endoscopic Trial

Development of High throughput Electrophysiology Assays of Recombinant Nav1.9 Channels

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