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Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR)

Drug metabolism reviews, 2006, Vol.38 (1-2), p.51-73

2006

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Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes

Toxicology and applied pharmacology, 2006-12, Vol.217 (2), p.225-233

2006

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UDP-glucuronosyltransferases and clinical drug-drug interactions

Pharmacology & therapeutics (Oxford), 2005-04, Vol.106 (1), p.97

2005

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Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone

Xenobiotica, 2004-04, Vol.34 (4), p.335-344

2004

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Valproic Acid I: Time Course of Lipid Peroxidation Biomarkers, Liver Toxicity, and Valproic Acid Metabolite Levels in Rats

Toxicological sciences, 2005-08, Vol.86 (2), p.427-435

2005

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Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes

Toxicological sciences, 2005-08, Vol.86 (2), p.436-443

2005

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Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2

The Journal of pharmacology and experimental therapeutics, 2001-12, Vol.299 (3), p.874

2001

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Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: Identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1

Toxicology and applied pharmacology, 2006-05, Vol.213 (1), p.18-26

2006

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Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study

Clinical pharmacology and therapeutics, 2011-06, Vol.89 (6), p.867-874

2011

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Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

Drug metabolism and disposition, 2003-01, Vol.31 (1), p.7-10

2003

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Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures : Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

Cancer research (Chicago, Ill.), 1997-05, Vol.57 (10), p.1946-1954

1997

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Pharmacogenetics: The therapeutic drug monitoring of the future?

Clinical pharmacokinetics, 2001, Vol.40 (11), p.783-802

2001

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In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1

Drug metabolism and disposition, 2002-04, Vol.30 (4), p.378-384

2002

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The effect of valproic acid on hepatic and plasma levels of 15-F 2t-isoprostane in rats

Free radical biology & medicine, 2003-06, Vol.34 (11), p.1435-1446

2003

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Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes

Drug metabolism and disposition, 2006-02, Vol.34 (2), p.234-242

2006

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Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450

Archives of biochemistry and biophysics, 1994-06, Vol.311 (2), p.437-442

1994

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Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation

Drug metabolism and disposition, 1997-08, Vol.25 (8), p.985

1997

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Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes

The pharmacogenomics journal, 2003-12, Vol.3 (6), p.335-342

2003

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Real-Time Polymerase Chain Reaction Analysis of CYP1B1 Gene Expression in Human Liver

Toxicological sciences, 2003-01, Vol.71 (1), p.11-19

2003

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The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6

Drug metabolism and disposition, 2004-04, Vol.32 (4), p.460-467

2004

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Dose-dependent protection of cardiac function by propofol during ischemia and early reperfusion in rats: effects on 15-F 2t -isoprostane formation

Canadian journal of physiology and pharmacology, 2003-01, Vol.81 (1), p.14-21

2003

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Pregnane X Receptor‐Mediated Transcription

Methods in Enzymology, 2005, Vol.400, p.588-598

2005

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Lack of evidence for induction of CYP2B1, CYP3A23, and CYP1A2 gene expression by Panax ginseng and Panax quinquefolius extracts in adult rats and primary cultures of rat hepatocytes

Drug metabolism and disposition, 2005-01, Vol.33 (1), p.19-22

2005

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Valproic acid glucuronidation is associated with increases in 15-F 2t-isoprostane in rats

Free radical biology & medicine, 2005-06, Vol.38 (11), p.1471-1483

2005

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Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols

Canadian journal of physiology and pharmacology, 2004-01, Vol.82 (1), p.57-64

2004

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Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR)

Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes

UDP-glucuronosyltransferases and clinical drug-drug interactions

Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone

Valproic Acid I: Time Course of Lipid Peroxidation Biomarkers, Liver Toxicity, and Valproic Acid Metabolite Levels in Rats

Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes

Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2

Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: Identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1

Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study

Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures : Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

Pharmacogenetics: The therapeutic drug monitoring of the future?

In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1

The effect of valproic acid on hepatic and plasma levels of 15-F 2t-isoprostane in rats

Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450

Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation

Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes

Real-Time Polymerase Chain Reaction Analysis of CYP1B1 Gene Expression in Human Liver

The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6

Dose-dependent protection of cardiac function by propofol during ischemia and early reperfusion in rats: effects on 15-F 2t -isoprostane formation

Pregnane X Receptor‐Mediated Transcription

Lack of evidence for induction of CYP2B1, CYP3A23, and CYP1A2 gene expression by Panax ginseng and Panax quinquefolius extracts in adult rats and primary cultures of rat hepatocytes

Valproic acid glucuronidation is associated with increases in 15-F 2t-isoprostane in rats

Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols

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