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Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac

Drug metabolism and disposition, 2013-12, Vol.41 (12), p.2024-2032

2013

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Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia

PloS one, 2018-06, Vol.13 (6), p.e0199177-e0199177

2018

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Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1940-1946

2014

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A novel system to determine activity of individual uridine 5′-diphospho-glucuronosyltransferase (UGT) isoforms: Recombinant UGT-beads

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107278-107278, Article 107278

2024

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HLM-beads: Rapid Assessment of Nonspecific Binding to Human Liver Microsomes Using Magnetizable Beads

Drug metabolism and disposition, 2021-12, Vol.49 (12), p.1056-1062

2021

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Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Drug metabolism and disposition, 2019-01, Vol.47 (1), p.58-66

2019

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Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture

Drug metabolism and disposition, 2020-08, Vol.48 (8), p.690-697

2020

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Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes

Journal of pharmaceutical sciences, 2024-07, Vol.113 (7), p.1987-1995

2024

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Human Liver Microsomes Immobilized on Magnetizable Beads: A Novel Approach to Study In Vitro Drug Metabolism

Drug metabolism and disposition, 2020-08, Vol.48 (8), p.645-654

2020

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Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac

Drug metabolism and disposition, 2014-03, Vol.42 (3), p.394-406

2014

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Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin

Pharmaceutical research, 2023-08, Vol.40 (8), p.1901-1913

2023

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Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes

Free radical biology & medicine, 2002, Vol.32 (1), p.2-10

2002

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The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]-BI 425809 in Healthy Males

Clinical drug investigation, 2022-01, Vol.42 (1), p.87-99

2022

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Correction to: The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]‑BI 425809 in Healthy Males

Clinical drug investigation, 2022-04, Vol.42 (4), p.375-375

2022

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Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor

European journal of drug metabolism and pharmacokinetics, 2022-01, Vol.47 (1), p.91-103

2022

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The impact of a CYP2C8-CYP3A4 protein–protein interaction on time dependent inhibition of CYP2C8

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S30-S30

2018

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The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress

Free radical biology & medicine, 2005-04, Vol.38 (7), p.867-873

2005

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Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics

Biochemical and biophysical research communications, 2001-04, Vol.282 (5), p.1161-1168

2001

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Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: In vitro and in vivo correlation

Journal of clinical pharmacology, 2015-04, Vol.55 (4), p.467-477

2015

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Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation

Biochemical and biophysical research communications, 2004-04, Vol.317 (1), p.149-156

2004

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Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation

Free radical biology & medicine, 2001-02, Vol.30 (4), p.370-382

2001

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Idiosyncratic NSAID drug induced oxidative stress

Chemico-biological interactions, 2002-11, Vol.142 (1), p.25-41

2002

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Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin

Molecular and cellular biochemistry, 2003-10, Vol.252 (1-2), p.205

2003

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Application of Quantitative Structure-Toxicity Relationships for the Comparison of the Cytotoxicity of 14 p-Benzoquinone Congeners in Primary Cultured Rat Hepatocytes Versus PC12 Cells

Toxicological sciences, 2004-09, Vol.81 (1), p.148-159

2004

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Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac

Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia

Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions

A novel system to determine activity of individual uridine 5′-diphospho-glucuronosyltransferase (UGT) isoforms: Recombinant UGT-beads

HLM-beads: Rapid Assessment of Nonspecific Binding to Human Liver Microsomes Using Magnetizable Beads

Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture

Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes

Human Liver Microsomes Immobilized on Magnetizable Beads: A Novel Approach to Study In Vitro Drug Metabolism

Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac

Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin

Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes

The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]-BI 425809 in Healthy Males

Correction to: The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]‑BI 425809 in Healthy Males

Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor

The impact of a CYP2C8-CYP3A4 protein–protein interaction on time dependent inhibition of CYP2C8

The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress

Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics

Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development

Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: In vitro and in vivo correlation

Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation

Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation

Idiosyncratic NSAID drug induced oxidative stress

Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin

Application of Quantitative Structure-Toxicity Relationships for the Comparison of the Cytotoxicity of 14 p-Benzoquinone Congeners in Primary Cultured Rat Hepatocytes Versus PC12 Cells

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