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Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Science (American Association for the Advancement of Science), 2020-09, Vol.369 (6508), p.1261-1265

2020

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Machine Learning Guided Design of High-Affinity ACE2 Decoys for SARS-CoV‑2 Neutralization

The journal of physical chemistry. B, 2023-03, Vol.127 (9), p.1995-2001

2023

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Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

Nature chemical biology, 2022-03, Vol.18 (3), p.342-351

2022

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An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2

EMBO molecular medicine, 2022-11, Vol.14 (11), p.e16109-n/a

2022

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Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Molecular therapy. Methods & clinical development, 2024-09, Vol.32 (3), p.101301, Article 101301

2024

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Computationally Designed ACE2 Decoy Receptor Binds SARS-CoV‑2 Spike (S) Protein with Tight Nanomolar Affinity

Journal of chemical information and modeling, 2021-09, Vol.61 (9), p.4656-4669

2021

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An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

Science advances, 2021-02, Vol.7 (8)

2021

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Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization

Biochemistry (Easton), 2009-06, Vol.48 (24), p.5518-5531

2009

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Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Effect of Solvent Viscosity on Kinetic Constants

Biochemistry (Easton), 2009-06, Vol.48 (24), p.5510-5517

2009

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An Examination of the Relationship between Active Site Loop Size and Thermodynamic Activation Parameters for Orotidine 5′-Monophosphate Decarboxylase from Mesophilic and Thermophilic Organisms

Biochemistry (Easton), 2009-08, Vol.48 (33), p.8006-8013

2009

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Introduction of a polar core into the de novo designed protein Top7

Protein science, 2016-07, Vol.25 (7), p.1299-1307

2016

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Structural Basis for Substrate Specificity in Phosphate Binding (β/α)8-Barrels: d-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12

Biochemistry (Easton), 2008-09, Vol.47 (36), p.9608-9617

2008

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Introduction of a polar core into the de novo designed protein T op7

Protein science, 2016-07, Vol.25 (7), p.1299-1307

2016

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Multinucleated stromal giant cells in mammary phyllodes tumours

Pathology, 2001, Vol.33 (2), p.153-156

2001

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Investigation of substrate specificity in phosphate binding barrels and mechanistic studies of orotidine monophosphate decarboxylase

Chan, Kui K

2006

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Objective monitoring tools for improved management of childhood asthma

Respiratory research, 2024-05, Vol.25 (1), p.194-194, Article 194

2024

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Cross-Cultural Validation of the Depression Anxiety Stress Scale-21 in China

Psychological assessment, 2016-05, Vol.28 (5), p.e88-e100

2016

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The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Genes & development, 2013-05, Vol.27 (9), p.985-990

2013

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Delays in Stroke Onset to Hospital Arrival Time During COVID-19

Stroke (1970), 2020-07, Vol.51 (7), p.2228-2231

2020

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Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: A descriptive cohort study among 1.1 million vaccinated people in Hong Kong

Journal of autoimmunity, 2022-06, Vol.130, p.102830-102830, Article 102830

2022

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Soft robotic manipulator for intraoperative MRI-guided transoral laser microsurgery

Science robotics, 2021-08, Vol.6 (57)

2021

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SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells

Molecular oncology, 2022-02, Vol.16 (4), p.860-884

2022

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MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis

Developmental cell, 2012-06, Vol.22 (6), p.1176-1190

2012

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Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

Nature communications, 2021-04, Vol.12 (1), p.2242-2242, Article 2242

2021

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Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Machine Learning Guided Design of High-Affinity ACE2 Decoys for SARS-CoV‑2 Neutralization

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2

Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation

Computationally Designed ACE2 Decoy Receptor Binds SARS-CoV‑2 Spike (S) Protein with Tight Nanomolar Affinity

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Effect of Solvent Viscosity on Kinetic Constants

An Examination of the Relationship between Active Site Loop Size and Thermodynamic Activation Parameters for Orotidine 5′-Monophosphate Decarboxylase from Mesophilic and Thermophilic Organisms

Introduction of a polar core into the de novo designed protein Top7

Structural Basis for Substrate Specificity in Phosphate Binding (β/α)8-Barrels: d-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12

Introduction of a polar core into the de novo designed protein T op7

Multinucleated stromal giant cells in mammary phyllodes tumours

Investigation of substrate specificity in phosphate binding barrels and mechanistic studies of orotidine monophosphate decarboxylase

Objective monitoring tools for improved management of childhood asthma

Cross-Cultural Validation of the Depression Anxiety Stress Scale-21 in China

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Delays in Stroke Onset to Hospital Arrival Time During COVID-19

Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: A descriptive cohort study among 1.1 million vaccinated people in Hong Kong

Soft robotic manipulator for intraoperative MRI-guided transoral laser microsurgery

SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells

Titin-truncating variants affect heart function in disease cohorts and the general population

MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis

Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

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