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Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (18), p.8709-8714

2019

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Dexras1 Interacts with FE65 to Regulate FE65-Amyloid Precursor Protein-dependent Transcription

The Journal of biological chemistry, 2008-12, Vol.283 (50), p.34728-34737

2008

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Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling

The AAPS journal, 2018-01, Vol.20 (1), p.23-23, Article 23

2018

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Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

Science (American Association for the Advancement of Science), 2002-02, Vol.295 (5556), p.865-868

2002

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A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia

Journal of medical genetics, 2014-09, Vol.51 (9), p.590-595

2014

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RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2

Movement disorders, 2021-11, Vol.36 (11), p.2519-2529

2021

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Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

Journal of the American Chemical Society, 2016-08, Vol.138 (30), p.9498-9507

2016

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The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells

Journal of general virology, 2005-07, Vol.86 (7), p.1921-1930

2005

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Rationally Designed Small Molecules That Target Both the DNA and RNA Causing Myotonic Dystrophy Type 1

Journal of the American Chemical Society, 2015-11, Vol.137 (44), p.14180-14189

2015

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Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery

International journal of pharmaceutics, 2018-03, Vol.539 (1-2), p.50-57

2018

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A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets

Cell reports (Cambridge), 2020-08, Vol.32 (6), p.108020, Article 108020

2020

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Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

Autophagy, 2012-01, Vol.8 (1), p.98-108

2012

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Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor

Journal of the American Chemical Society, 2014-04, Vol.136 (17), p.6355-6361

2014

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Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations

Journal of pharmaceutical and biomedical analysis, 2020-01, Vol.178, p.112946-112946, Article 112946

2020

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Maternal oxytocin responsiveness improves specificity of positive social memory recall

Psychoneuroendocrinology, 2018-12, Vol.98, p.148-152

2018

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Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration

European journal of pharmaceutical sciences, 2019-01, Vol.127, p.240-251

2019

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A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy

ChemMedChem, 2016-07, Vol.11 (13), p.1428-1435

2016

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Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats

Journal of pharmaceutical and biomedical analysis, 2016-06, Vol.125, p.41-47

2016

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role of ubiquitin linkages on α-synuclein induced-toxicity in a Drosophila model of Parkinson's disease

Journal of neurochemistry, 2009-07, Vol.110 (1), p.208-219

2009

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Sodium dodecyl sulfate-insoluble oligomers are involved in polyglutamine degeneration

The FASEB journal, 2008-09, Vol.22 (9), p.3348-3357

2008

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A mannose/glucose-specific lectin from Chinese evergreen chinkapin ( Castanopsis chinensis)

Biochimica et biophysica acta, 2008-09, Vol.1780 (9), p.1017-1022

2008

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Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias

Cerebellum (London, England), 2007-01, Vol.6 (2), p.111-117

2007

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Through regulating Ubiquitin E3 ligase in achieving degradation of aggregated protein and suppression of cell death in polyglutamine degeneration

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

Chan, Edwin HY

2020

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The role of ubiquitin linkages on [alpha]-synuclein induced-toxicity in a Drosophila model of Parkinson's disease

Journal of neurochemistry, 2009-07, Vol.110 (1), p.208-219

2009

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The Drosophila embargoed Gene Is Required for Larval Progression and Encodes the Functional Homolog of Schizosaccharomyces Crm1

Genetics (Austin), 2000-08, Vol.155 (4), p.1799-1807

2000

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Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

Dexras1 Interacts with FE65 to Regulate FE65-Amyloid Precursor Protein-dependent Transcription

Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling

Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia

RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells

Rationally Designed Small Molecules That Target Both the DNA and RNA Causing Myotonic Dystrophy Type 1

Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery

A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor

Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations

Maternal oxytocin responsiveness improves specificity of positive social memory recall

Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy

Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats

role of ubiquitin linkages on α-synuclein induced-toxicity in a Drosophila model of Parkinson's disease

Sodium dodecyl sulfate-insoluble oligomers are involved in polyglutamine degeneration

A mannose/glucose-specific lectin from Chinese evergreen chinkapin ( Castanopsis chinensis)

Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias

Through regulating Ubiquitin E3 ligase in achieving degradation of aggregated protein and suppression of cell death in polyglutamine degeneration

The role of ubiquitin linkages on [alpha]-synuclein induced-toxicity in a Drosophila model of Parkinson's disease

The Drosophila embargoed Gene Is Required for Larval Progression and Encodes the Functional Homolog of Schizosaccharomyces Crm1

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