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5-Substituted Pyrimidines with a 1,5-Anhydro-2,3-dideoxy-d-arabino-hexitol Moiety at N-1: Synthesis, Antiviral Activity, Conformational Analysis, and Interaction with Viral Thymidine Kinase

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4343-4353

1998

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Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

Nature structural biology, 1997-06, Vol.4 (6), p.490-497

1997

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2.0 Å X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue

FEBS letters, 1999-07, Vol.456 (1), p.49-53

1999

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Pyrrolo[2,3- d]pyrimidines and pyrido[2,3- d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim

Bioorganic & medicinal chemistry, 1996-04, Vol.4 (4), p.593-602

1996

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Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

Proteins, structure, function, and bioinformatics, 1998-08, Vol.32 (3), p.350-361

1998

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Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3503-3510

1993

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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Journal of medicinal chemistry, 1985-03, Vol.28 (3), p.303-311

1985

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2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes

Journal of medicinal chemistry, 1987-02, Vol.30 (2), p.348-356

1987

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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Journal of medicinal chemistry, 1982-10, Vol.25 (10), p.1120-1122

1982

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Structure to 1.9 Å resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir

FEBS letters, 1999-01, Vol.443 (2), p.121-125

1999

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The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures

St. Andrews, Scotland, September 21-24 1982, 1983, Vol.7, p.505-510

Originally published 1983, 1983

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Crystal structure of Escherichia coli UvrB C-terminal domain, and a model for UvrB-UvrC interaction

FEBS letters, 2000-01, Vol.465 (2), p.161-164

2000

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A Silver(I) Difluorophosphate(V)-tetramethylhexathiaadamantane Coordination Polymer with a 3-D Rutile (TiO2) Framework Construction

Crystal growth & design, 2001-09, Vol.1 (5), p.395-399

2001

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Anion influence on co-ordination polymers of Ag(I) with 1,4-dithiacyclohexane

Dalton : an international journal of inorganic chemistry, 2001-09 (17), p.2530-2538

2001

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Bridging mode flexibility of 1,3-dithiacyclohexane in silver(i) co-ordination polymers

Dalton : an international journal of inorganic chemistry, 2002 (22), p.4134

2002

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Recent developments

Law teacher, 1978-01, Vol.12 (3), p.222-239

1978

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X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase

St. Andrews, Scotland, September 21-24 1982, 1983, Vol.7, p.545-550

Originally published 1983, 1983

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5-Substituted Pyrimidines with a 1,5-Anhydro-2,3-dideoxy-d-arabino-hexitol Moiety at N-1: Synthesis, Antiviral Activity, Conformational Analysis, and Interaction with Viral Thymidine Kinase

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

2.0 Å X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue

Pyrrolo[2,3- d]pyrimidines and pyrido[2,3- d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Structure to 1.9 Å resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir

The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures

Crystal structure of Escherichia coli UvrB C-terminal domain, and a model for UvrB-UvrC interaction

A Silver(I) Difluorophosphate(V)-tetramethylhexathiaadamantane Coordination Polymer with a 3-D Rutile (TiO2) Framework Construction

Anion influence on co-ordination polymers of Ag(I) with 1,4-dithiacyclohexane

Bridging mode flexibility of 1,3-dithiacyclohexane in silver(i) co-ordination polymers

Recent developments

X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase

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