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How to proceed? Application to cardiovascular system: Integrating safety pharmacology in the design of regulatory toxicology studies: The pros and cons

Toxicology letters, 2011-08, Vol.205, p.S23-S23

Champeroux, P.

2011

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Evaluation of cardiovascular effects of intravenous robenacoxib in dogs

Journal of veterinary pharmacology and therapeutics, 2017-12, Vol.40 (6), p.e62-e64

2017

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Short‐term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high‐frequency autonomic oscillations

British journal of pharmacology, 2015-06, Vol.172 (11), p.2878-2891

2015

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The high frequency relationship: implications for torsadogenic hERG blockers

British journal of pharmacology, 2016-02, Vol.173 (3), p.601-612

2016

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Cardioprotection by omega-3 fatty acids: Involvement of PKCs?

Prostaglandins, leukotrienes and essential fatty acids, 2010-04, Vol.82 (4), p.173-177

2010

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Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes

British journal of pharmacology, 2003-06, Vol.139 (4), p.816-822

2003

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P14-16: Marmoset (a small size NHP): Incorporation of safety pharmacology endpoints in toxicology studies

Toxicology letters, 2023-09, Vol.384, p.S172-S172

2023

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G018 Evaluation of IKr blocking properties of different molecules with or without torsadogenic properties

Archives of cardiovascular diseases, 2009, Vol.102, p.S68-S68

2009

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Dietary long-chain omega-3 fatty acids of marine origin: A comparison of their protective effects on coronary heart disease and breast cancers

Progress in biophysics and molecular biology, 2006, Vol.90 (1), p.299-325

2006

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An optimised methodology for the neurobehavioural assessment in rodents

Journal of pharmacological and toxicological methods, 2007-09, Vol.56 (2), p.239-255

2007

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Central hypervolemia in the conscious rat: a model of cardiovascular deconditioning

Journal of applied physiology (1985), 1996-04, Vol.80 (4), p.1390-1396

1996

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The preclinical assessment of the risk for QT interval prolongation

Therapie, 2000-01, Vol.55 (1), p.101

2000

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Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres

British journal of pharmacology, 2005-02, Vol.144 (3), p.376-385

2005

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Evaluation of effects on respiration in conscious cynomolgus monkeys (Macaca fascicularis) using whole body plethysmogra

Journal of pharmacological and toxicological methods, 2008-09, Vol.58 (2), p.176-176

2008

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Design of a computer sleep-scoring algorithm and validation by testing of flunitrazepam and caffeine on the sleep-wake cycle

Journal of pharmacological and toxicological methods, 2008-09, Vol.58 (2), p.168-168

2008

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Calculation of QT shift in non clinical safety pharmacology studies

Journal of pharmacological and toxicological methods, 2009-03, Vol.59 (2), p.73-85

2009

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Comparative antihypertensive and renoprotective effects of telmisartan and lisinopril after long-term treatment in hypertensive diabetic rats

Journal of the renin-angiotensin-aldosterone system, 2001-03, Vol.2 (1), p.31-36

2001

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Early disturbance of baroreflex control of heart rate after tail suspension in conscious rats

American journal of physiology. Heart and circulatory physiology, 1994-12, Vol.267 (6), p.H2407-H2412

1994

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Pharmacokinetics of ketoprofen in rabbit after a single topical application

European journal of drug metabolism and pharmacokinetics, 2000-07, Vol.25 (3-4), p.227-230

2000

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Pharmacological properties of trimebutine and N-monodesmethyltrimebutine

The Journal of pharmacology and experimental therapeutics, 1999-06, Vol.289 (3), p.1391

1999

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Role of endothelium in the endothelin-1-mediated potentiation of the norepinephrine response in the aorta of hypertensive rats

Journal of hypertension, 1997-10, Vol.15 (10), p.1101-1111

1997

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Peroxidation of docosahexaenoic acid is responsible for its effects on ITO and ISS in rat ventricular myocytes

British journal of pharmacology, 2003-06, Vol.139 (4), p.816-822

2003

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CENTRAL CARDIOVASCULAR EFFECTS OF DIHYDROPYRIDINES IN SPONTANEOUSLY HYPERTENSIVE RATS

Fundamental & clinical pharmacology, 1989-12, Vol.3 (S1), p.47s-56s

1989

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Mechanisms of the cardiovascular deconditioning induced by tail suspension in the rat

American journal of physiology. Heart and circulatory physiology, 1998-05, Vol.274 (5), p.H1667-H1673

1998

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Effects of clomipramine hydrochloride on heart rate and rhythm in healthy dogs

American journal of veterinary research, 2000-08, Vol.61 (8), p.960-964

2000

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How to proceed? Application to cardiovascular system: Integrating safety pharmacology in the design of regulatory toxicology studies: The pros and cons

Evaluation of cardiovascular effects of intravenous robenacoxib in dogs

Short‐term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high‐frequency autonomic oscillations

The high frequency relationship: implications for torsadogenic hERG blockers

Cardioprotection by omega-3 fatty acids: Involvement of PKCs?

Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes

P14-16: Marmoset (a small size NHP): Incorporation of safety pharmacology endpoints in toxicology studies

G018 Evaluation of IKr blocking properties of different molecules with or without torsadogenic properties

Dietary long-chain omega-3 fatty acids of marine origin: A comparison of their protective effects on coronary heart disease and breast cancers

An optimised methodology for the neurobehavioural assessment in rodents

Central hypervolemia in the conscious rat: a model of cardiovascular deconditioning

The preclinical assessment of the risk for QT interval prolongation

Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres

Evaluation of effects on respiration in conscious cynomolgus monkeys (Macaca fascicularis) using whole body plethysmogra

Design of a computer sleep-scoring algorithm and validation by testing of flunitrazepam and caffeine on the sleep-wake cycle

Calculation of QT shift in non clinical safety pharmacology studies

Comparative antihypertensive and renoprotective effects of telmisartan and lisinopril after long-term treatment in hypertensive diabetic rats

Early disturbance of baroreflex control of heart rate after tail suspension in conscious rats

Pharmacokinetics of ketoprofen in rabbit after a single topical application

Pharmacological properties of trimebutine and N-monodesmethyltrimebutine

Role of endothelium in the endothelin-1-mediated potentiation of the norepinephrine response in the aorta of hypertensive rats

Peroxidation of docosahexaenoic acid is responsible for its effects on ITO and ISS in rat ventricular myocytes

CENTRAL CARDIOVASCULAR EFFECTS OF DIHYDROPYRIDINES IN SPONTANEOUSLY HYPERTENSIVE RATS

Mechanisms of the cardiovascular deconditioning induced by tail suspension in the rat

Effects of clomipramine hydrochloride on heart rate and rhythm in healthy dogs

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