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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

Nature chemical biology, 2020-03, Vol.16 (3), p.240-249

2020

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Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma

American journal of respiratory and critical care medicine, 2012-02, Vol.185 (3), p.267-274

2012

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Alternative splicing of G protein-coupled receptors: physiology and pathophysiology

Cellular and molecular life sciences : CMLS, 2009-10, Vol.66 (20), p.3337-3352

2009

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Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

PloS one, 2015-03, Vol.10 (3), p.e0121285

2015

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HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4

Journal of allergy and clinical immunology, 2017-08, Vol.140 (2), p.584-587.e8

2017

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Regulation of neuronal plasticity and fear by a dynamic change in PAR1―G protein coupling in the amygdala

Molecular psychiatry, 2013-10, Vol.18 (10), p.1136-1145

2013

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Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability

PLoS biology, 2018-04, Vol.16 (4), p.e2003611

2018

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Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse

Neuron (Cambridge, Mass.), 2008-11, Vol.60 (4), p.642-656

2008

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Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy

The Journal of neuroscience, 2013-03, Vol.33 (13), p.5626-5637

2013

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FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists

PloS one, 2012, Vol.7 (1), p.e29946

2012

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Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose

British journal of pharmacology, 2016-03, Vol.173 (5), p.870-887

2016

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GRK2 expression and catalytic activity are essential for vasoconstrictor/ERK-stimulated arterial smooth muscle proliferation

Biochemical pharmacology, 2023-10, Vol.216, p.115795, Article 115795

2023

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Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation

The Journal of pharmacology and experimental therapeutics, 2009-12, Vol.331 (3), p.1086

2009

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Endogenous G Protein-coupled Receptor Kinase 6 Regulates M3 Muscarinic Acetylcholine Receptor Phosphorylation and Desensitization in Human SH-SY5Y Neuroblastoma Cells

The Journal of biological chemistry, 2002-05, Vol.277 (18), p.15523-15529

2002

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Arrestins differentially regulate histamine‐ and oxytocin‐evoked phospholipase C and mitogen‐activated protein kinase signalling in myometrial cells

British journal of pharmacology, 2011-04, Vol.162 (7), p.1603-1617

2011

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[Ca2+]i oscillations in ASM: Relationship with persistent airflow obstruction in asthma

Respirology (Carlton, Vic.), 2014-07, Vol.19 (5), p.763-766

2014

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Effects of Positive Allosteric Modulators on Single-Cell Oscillatory Ca2+ Signaling Initiated by the Type 5 Metabotropic Glutamate Receptor

Molecular pharmacology, 2009-12, Vol.76 (6), p.1302-1313

2009

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G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors

Biochemical pharmacology, 2012-08, Vol.84 (3), p.249-259

2012

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Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor

Molecular pharmacology, 2018-07, Vol.94 (1), p.674-688

2018

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An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory

The Journal of biological chemistry, 2016-04, Vol.291 (17), p.8862-8875

2016

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Single Cell Analysis and Temporal Profiling of Agonist-mediated Inositol 1,4,5-Trisphosphate, Ca2+, Diacylglycerol, and Protein Kinase C Signaling using Fluorescent Biosensors

The Journal of biological chemistry, 2005-06, Vol.280 (23), p.21837-21846

2005

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Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions

Molecular pharmacology, 2018-09, Vol.94 (3), p.1079-1091

2018

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Novel Structural and Functional Insights into M3 Muscarinic Receptor Dimer/Oligomer Formation

The Journal of biological chemistry, 2013-11, Vol.288 (48), p.34777-34790

2013

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Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2

Cardiovascular research, 2010-02, Vol.85 (3), p.424-433

2010

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Imaging of Muscarinic Acetylcholine Receptor Signaling in Hippocampal Neurons: Evidence for Phosphorylation-Dependent and -Independent Regulation by G-Protein-Coupled Receptor Kinases

The Journal of neuroscience, 2004-04, Vol.24 (17), p.4157-4162

2004

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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma

Alternative splicing of G protein-coupled receptors: physiology and pathophysiology

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4

Regulation of neuronal plasticity and fear by a dynamic change in PAR1―G protein coupling in the amygdala

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability

Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse

Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy

FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists

Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose

GRK2 expression and catalytic activity are essential for vasoconstrictor/ERK-stimulated arterial smooth muscle proliferation

Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation

Endogenous G Protein-coupled Receptor Kinase 6 Regulates M3 Muscarinic Acetylcholine Receptor Phosphorylation and Desensitization in Human SH-SY5Y Neuroblastoma Cells

Arrestins differentially regulate histamine‐ and oxytocin‐evoked phospholipase C and mitogen‐activated protein kinase signalling in myometrial cells

[Ca2+]i oscillations in ASM: Relationship with persistent airflow obstruction in asthma

Effects of Positive Allosteric Modulators on Single-Cell Oscillatory Ca2+ Signaling Initiated by the Type 5 Metabotropic Glutamate Receptor

G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors

Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor

An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory

Single Cell Analysis and Temporal Profiling of Agonist-mediated Inositol 1,4,5-Trisphosphate, Ca2+, Diacylglycerol, and Protein Kinase C Signaling using Fluorescent Biosensors

Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions

Novel Structural and Functional Insights into M3 Muscarinic Receptor Dimer/Oligomer Formation

Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2

Imaging of Muscarinic Acetylcholine Receptor Signaling in Hippocampal Neurons: Evidence for Phosphorylation-Dependent and -Independent Regulation by G-Protein-Coupled Receptor Kinases

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