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Beyond Ketamine: New Approaches to the Development of Safer Antidepressants

Current neuropharmacology, 2017-10, Vol.15 (7), p.963-976

Chaki, Shigeyuki

2017

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Recent advances in the antidepressant actions of ketamine and agents having ketamine-like antidepressant profiles

Pharmacology, biochemistry and behavior, 2020-09, Vol.196, p.172995-172995, Article 172995

Chaki, Shigeyuki

2020

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Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

Behavioural brain research, 2014-09, Vol.271, p.111-115

2014

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Antidepressants in the post-ketamine Era: Pharmacological approaches targeting the glutamatergic system

Neuropharmacology, 2023-02, Vol.223, p.109348-109348, Article 109348

2023

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Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia

European journal of pharmacology, 2010-08, Vol.639 (1), p.59-66

Chaki, Shigeyuki

2010

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The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN

Neuropsychopharmacology (New York, N.Y.), 2016-03, Vol.41 (4), p.1046-1056

2016

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Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

Behavioural brain research, 2011-10, Vol.224 (1), p.107-111

2011

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(R)-ketamine shows greater potency and longer lasting antidepressant effects than its metabolite (2R,6R)-hydroxynorketamine

Biological psychiatry (1969), 2017-09, Vol.82 (5), p.e43-e44

2017

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Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine

The international journal of neuropsychopharmacology, 2018-04, Vol.21 (4), p.371-381

2018

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Role of Serotonergic System in the Antidepressant Actions of mGlu2/3 Receptor Antagonists: Similarity to Ketamine

International journal of molecular sciences, 2019-03, Vol.20 (6), p.1270

2019

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Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid (LY341495), and an N-methyl-D-aspartate receptor antagonist, ketamine, in the novelty-suppressed feeding test

Psychopharmacology, 2014-06, Vol.231 (11), p.2291-2298

2014

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Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation

Neuropsychopharmacology (New York, N.Y.), 2020-09, Vol.45 (10), p.1725-1734

2020

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5-HT1A receptor stimulation in the medial prefrontal cortex mediates the antidepressant effects of mGlu2/3 receptor antagonist in mice

Neuropharmacology, 2018-07, Vol.137, p.96-103

2018

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Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression

Behavioural brain research, 2013-02, Vol.238, p.48-52

2013

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Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

Neuropharmacology, 2011-12, Vol.61 (8), p.1419-1423

2011

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mGlu2/3 Receptor Antagonists as Novel Antidepressants

Trends in pharmacological sciences (Regular ed.), 2017-06, Vol.38 (6), p.569-580

Chaki, Shigeyuki

2017

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Melanin-concentrating hormone receptor: A therapeutic target for novel anxiolytics

Pharmacology, biochemistry and behavior, 2024-09, Vol.242, p.173818, Article 173818

Chaki, Shigeyuki

2024

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Involvement of serotonergic system in the effect of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

Journal of pharmacological sciences, 2015-01, Vol.127 (1), p.57-61

2015

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Effects of ketamine and LY341495 on the depressive-like behavior of repeated corticosterone-injected rats

Pharmacology, biochemistry and behavior, 2013-06, Vol.107, p.20-23

2013

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Pharmacological characterization of repeated corticosterone injection-induced depression model in rats

Brain research, 2010-11, Vol.1359, p.75-80

2010

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d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats

Psychopharmacologia, 2010-04, Vol.209 (3), p.263-270

2010

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Neurochemistry of the Nucleus Accumbens and its Relevance to Depression and Antidepressant Action in Rodents

Current neuropharmacology, 2006-10, Vol.4 (4), p.277-291

2006

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Differential effects of NMDA receptor antagonists at lower and higher doses on basal gamma band oscillation power in rat cortical electroencephalograms

Neuropharmacology, 2014-10, Vol.85, p.384-396

2014

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d-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats

Behavioural brain research, 2008-01, Vol.186 (1), p.78-83

2008

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Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model

Psychopharmacology, 2018-11, Vol.235 (11), p.3177-3185

2018

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Beyond Ketamine: New Approaches to the Development of Safer Antidepressants

Recent advances in the antidepressant actions of ketamine and agents having ketamine-like antidepressant profiles

Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

Antidepressants in the post-ketamine Era: Pharmacological approaches targeting the glutamatergic system

Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia

The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(R)-ketamine shows greater potency and longer lasting antidepressant effects than its metabolite (2R,6R)-hydroxynorketamine

Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine

Role of Serotonergic System in the Antidepressant Actions of mGlu2/3 Receptor Antagonists: Similarity to Ketamine

Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid (LY341495), and an N-methyl-D-aspartate receptor antagonist, ketamine, in the novelty-suppressed feeding test

Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation

5-HT1A receptor stimulation in the medial prefrontal cortex mediates the antidepressant effects of mGlu2/3 receptor antagonist in mice

Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression

Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

mGlu2/3 Receptor Antagonists as Novel Antidepressants

Melanin-concentrating hormone receptor: A therapeutic target for novel anxiolytics

Involvement of serotonergic system in the effect of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

Effects of ketamine and LY341495 on the depressive-like behavior of repeated corticosterone-injected rats

Pharmacological characterization of repeated corticosterone injection-induced depression model in rats

d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats

Neurochemistry of the Nucleus Accumbens and its Relevance to Depression and Antidepressant Action in Rodents

Differential effects of NMDA receptor antagonists at lower and higher doses on basal gamma band oscillation power in rat cortical electroencephalograms

d-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model

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