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Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

Nature communications, 2021-08, Vol.12 (1), p.4721-15, Article 4721

2021

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Decoding the Conformational Selective Mechanism of FGFR Isoforms: A Comparative Molecular Dynamics Simulation

Molecules (Basel, Switzerland), 2023-03, Vol.28 (6), p.2709

2023

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Mechanistic Insights into the Mechanism of Inhibitor Selectivity toward the Dark Kinase STK17B against Its High Homology STK17A

Molecules (Basel, Switzerland), 2022-07, Vol.27 (14), p.4655

2022

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Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer

Journal of cancer research and clinical oncology, 2020-10, Vol.146 (10), p.2509-2517

2020

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Investigation of PM2.5-induced carcinogenic effects through mediation of ErbB family based on DNA methylation and transcriptomics analysis by a lung-mimicking microfluidic platform

Ecotoxicology and environmental safety, 2022-12, Vol.248, p.114318, Article 114318

2022

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Insights into the Allosteric Effect of SENP1 Q597A Mutation on the Hydrolytic Reaction of SUMO1 via an Integrated Computational Study

Molecules (Basel, Switzerland), 2022-06, Vol.27 (13), p.4149

2022

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Atomic-scale insights into allosteric inhibition and evolutional rescue mechanism of Streptococcus thermophilus Cas9 by the anti-CRISPR protein AcrIIA6

Computational and structural biotechnology journal, 2021-01, Vol.19, p.6108-6124

2021

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Elucidation of the conformational dynamics and assembly of Argonaute–RNA complexes by distinct yet coordinated actions of the supplementary microRNA

Computational and structural biotechnology journal, 2022-01, Vol.20, p.1352-1365

2022

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All-trans-retinoic acid (ATRA) plus oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carcinoma and extrahepatic metastasis: study protocol for a randomized controlled trial

Trials, 2019-04, Vol.20 (1), p.245-245, Article 245

2019

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Understanding the P-Loop Conformation in the Determination of Inhibitor Selectivity Toward the Hepatocellular Carcinoma-Associated Dark Kinase STK17B

Frontiers in molecular biosciences, 2022-05, Vol.9, p.901603-901603

2022

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Mechanistic Insights into the Protection Effect of Argonaute–RNA Complex on the HCV Genome

Biomolecules (Basel, Switzerland), 2022-11, Vol.12 (11), p.1631

2022

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Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

Acta pharmaceutica Sinica. B, 2021-11, Vol.11 (11), p.3433-3446

2021

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Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1

Frontiers in cell and developmental biology, 2021-03, Vol.9, p.644716-644716

2021

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Along the allostery stream: Recent advances in computational methods for allosteric drug discovery

Wiley interdisciplinary reviews. Computational molecular science, 2022-07, Vol.12 (4), p.e1585-n/a

2022

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Decoupling the dynamic mechanism revealed by FGFR2 mutation-induced population shift

Journal of biomolecular structure & dynamics, 2024-03, Vol.42 (4), p.1940-1951

2024

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Postoperative adjuvant IMRT for patients with HCC and portal vein tumor thrombus: An open-label randomized controlled trial

Radiotherapy and oncology, 2019-11, Vol.140, p.20-25

2019

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Morphine promotes angiogenesis by activating PI3K/Akt/HIF-1α pathway and upregulating VEGF in hepatocellular carcinoma

Journal of gastrointestinal oncology, 2021-08, Vol.12 (4), p.1761-1772

2021

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The allosteric effect of the upper half of SENP1 contributes to its substrate selectivity for SUMO1 over SUMO2

Journal of biomolecular structure & dynamics, 2023-12, Vol.ahead-of-print (ahead-of-print), p.1-15

2023

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Cover Image, Volume 12, Issue 4

Wiley interdisciplinary reviews. Computational molecular science, 2022-07, Vol.12 (4), p.n/a

2022

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MicroRNA-101 modulates cisplatin chemoresistance in liver cancer cells via the DNA-PKcs signaling pathway

Oncology letters, 2019-10, Vol.18 (4), p.3655-3663

2019

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All-trans Retinoic Acid combined with oxaliplatin suppressed proliferation of chemo-resistant hepatocellular carcinoma cells by inducing G2/M cell cycle arrest

Archives of medical science, 2021-08

2021

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DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-κB pathway

Molecular and cellular biochemistry, 2015-01, Vol.399 (1-2), p.269-278

2015

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All-trans-retinoic acid versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carcinoma and extrahepatic metastasis: study protocol for a randomized controlled trial

Trials, 2019-04, Vol.20 (1)

2019

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Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3

Journal of Cancer, 2017-01, Vol.8 (18), p.3742-3754

2017

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Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice

Biochimica et biophysica acta. Molecular basis of disease, 2022-12, Vol.1868 (12), p.166556, Article 166556

2022

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Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

Decoding the Conformational Selective Mechanism of FGFR Isoforms: A Comparative Molecular Dynamics Simulation

Mechanistic Insights into the Mechanism of Inhibitor Selectivity toward the Dark Kinase STK17B against Its High Homology STK17A

Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer

Investigation of PM2.5-induced carcinogenic effects through mediation of ErbB family based on DNA methylation and transcriptomics analysis by a lung-mimicking microfluidic platform

Insights into the Allosteric Effect of SENP1 Q597A Mutation on the Hydrolytic Reaction of SUMO1 via an Integrated Computational Study

Atomic-scale insights into allosteric inhibition and evolutional rescue mechanism of Streptococcus thermophilus Cas9 by the anti-CRISPR protein AcrIIA6

Elucidation of the conformational dynamics and assembly of Argonaute–RNA complexes by distinct yet coordinated actions of the supplementary microRNA

All-trans-retinoic acid (ATRA) plus oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carcinoma and extrahepatic metastasis: study protocol for a randomized controlled trial

Understanding the P-Loop Conformation in the Determination of Inhibitor Selectivity Toward the Hepatocellular Carcinoma-Associated Dark Kinase STK17B

Mechanistic Insights into the Protection Effect of Argonaute–RNA Complex on the HCV Genome

Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1

Along the allostery stream: Recent advances in computational methods for allosteric drug discovery

Decoupling the dynamic mechanism revealed by FGFR2 mutation-induced population shift

Postoperative adjuvant IMRT for patients with HCC and portal vein tumor thrombus: An open-label randomized controlled trial

Morphine promotes angiogenesis by activating PI3K/Akt/HIF-1α pathway and upregulating VEGF in hepatocellular carcinoma

The allosteric effect of the upper half of SENP1 contributes to its substrate selectivity for SUMO1 over SUMO2

Cover Image, Volume 12, Issue 4

MicroRNA-101 modulates cisplatin chemoresistance in liver cancer cells via the DNA-PKcs signaling pathway

All-trans Retinoic Acid combined with oxaliplatin suppressed proliferation of chemo-resistant hepatocellular carcinoma cells by inducing G2/M cell cycle arrest

DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-κB pathway

All-trans-retinoic acid versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carcinoma and extrahepatic metastasis: study protocol for a randomized controlled trial

Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3

Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice

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