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A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

Cell metabolism, 2016-03, Vol.23 (3), p.427-440

2016

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Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice

PloS one, 2015-03, Vol.10 (3), p.e0119104-e0119104

2015

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Assessing the Feasibility of Neutralizing Osteopontin with Various Therapeutic Antibody Modalities

Scientific reports, 2018-05, Vol.8 (1), p.7781-7, Article 7781

2018

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Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

Toxicological sciences, 2008-09, Vol.105 (1), p.97-105

2008

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Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates

Diabetes, obesity & metabolism, 2017-12, Vol.19 (12), p.1762-1772

2017

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Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

Scientific reports, 2021-04, Vol.11 (1), p.8921-12, Article 8921

2021

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Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock

Nature, 2007-12, Vol.450 (7173), p.1249-1252

2007

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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5704-5718

2018

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Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.501-511

2017

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Probing Polymerization Forces by Using Actin-Propelled Lipid Vesicles

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (8), p.4521-4526

2003

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Liver‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis

Angewandte Chemie International Edition, 2017-12, Vol.56 (51), p.16218-16222

International ed. in English, 2017

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Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation

British journal of pharmacology, 2017-01, Vol.174 (1), p.70-81

2017

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Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

Scientific reports, 2018-03, Vol.8 (1), p.4241-15, Article 4241

2018

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A Mechanistic Site-Of-Action Model: A Tool for Informing Right Target, Right Compound, And Right Dose for Therapeutic Antagonistic Antibody Programs

Frontiers in bioinformatics, 2021-09, Vol.1, p.731340-731340

2021

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Social context of shell acquisition in Coenobita clypeatus hermit crabs

Behavioral ecology, 2010-05, Vol.21 (3), p.639-646

2010

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Analysis of Mechanistic Pathway Models in Drug Discovery: p38 Pathway

Biotechnology progress, 2008-01, Vol.24 (1), p.96-109

2008

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Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro

BMC systems biology, 2010-03, Vol.4 (1), p.23-23, Article 23

2010

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Pendent polyimides using mellitic acid dianhydride. III. The effect of pendent group functionality on polymer properties

Journal of applied polymer science, 2009-07, Vol.113 (2), p.1198-1206

2009

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Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9

The Journal of biological chemistry, 2012-03, Vol.287 (14), p.11090-11097

2012

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Abstract 3056: Growth differentiation factor 15 (GDF-15) inhibition attenuates platinum-based chemotherapy-induced emesis, anorexia and weight loss and increases survival

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.3056-3056

2020

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Growth differentiation factor 15 (GDF-15) as a key regulator of cachexia induced by platinum-based chemotherapy

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.e24162-e24162

2020

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Pharmacokinetics and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice

PloS one, 2015-03, Vol.10 (3)

2015

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Comprehensive mechanism-based antibody pharmacokinetic modeling

2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011, Vol.2011, p.4318-4323

2011

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Modeling Efficacy and Safety of Engineered Biologics

Drug Efficacy, Safety, and Biologics Discovery, 2008, p.301-326

2008

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A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice

Assessing the Feasibility of Neutralizing Osteopontin with Various Therapeutic Antibody Modalities

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock

Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome

Probing Polymerization Forces by Using Actin-Propelled Lipid Vesicles

Liver‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis

Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation

Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

A Mechanistic Site-Of-Action Model: A Tool for Informing Right Target, Right Compound, And Right Dose for Therapeutic Antagonistic Antibody Programs

Social context of shell acquisition in Coenobita clypeatus hermit crabs

Analysis of Mechanistic Pathway Models in Drug Discovery: p38 Pathway

Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro

Liver‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis

Pendent polyimides using mellitic acid dianhydride. III. The effect of pendent group functionality on polymer properties

Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9

Abstract 3056: Growth differentiation factor 15 (GDF-15) inhibition attenuates platinum-based chemotherapy-induced emesis, anorexia and weight loss and increases survival

Growth differentiation factor 15 (GDF-15) as a key regulator of cachexia induced by platinum-based chemotherapy

Pharmacokinetics and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice

Comprehensive mechanism-based antibody pharmacokinetic modeling

Modeling Efficacy and Safety of Engineered Biologics

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