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Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

Nature genetics, 2016-06, Vol.48 (6), p.675-680

2016

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G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs

Science signaling, 2018-10, Vol.11 (552)

2018

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Purinergic Receptors Crosstalk with CCR5 to Amplify Ca2+ Signaling

Cellular and molecular neurobiology, 2021-07, Vol.41 (5), p.1085-1101

2021

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Development of original metabolically stable apelin‐17 analogs with diuretic and cardiovascular effects

The FASEB journal, 2017-02, Vol.31 (2), p.687-700

2017

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Multiplexed analysis of the secretin-like GPCR-RAMP interactome

Science advances, 2019-09, Vol.5 (9), p.eaaw2778-eaaw2778

2019

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Application of bioluminescence resonance energy transfer to quantitate cell-surface expression of membrane proteins

Analytical biochemistry, 2024-01, Vol.684, p.115361-115361, Article 115361

2024

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Itch receptor MRGPRX4 interacts with the receptor activity–modifying proteins

The Journal of biological chemistry, 2023-05, Vol.299 (5), p.104664-104664, Article 104664

2023

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Biased Signaling Favoring Gi over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine

The Journal of biological chemistry, 2014-08, Vol.289 (35), p.24599-24610

2014

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Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling

The Journal of biological chemistry, 2021-01, Vol.296, p.100163-100163, Article 100163

2021

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Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells

Journal of the American Chemical Society, 2023-05, Vol.145 (20), p.11173-11184

2023

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Abstract A07: Activating mutations in uveal melanoma convey sensitivity to g-alpha q inhibition

Cancer research (Chicago, Ill.), 2020-10, Vol.80 (19_Supplement), p.A07-A07

2020

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Peptide Agonist Docking in the N-terminal Ectodomain of a Class II G Protein-coupled Receptor, the VPAC1 Receptor

The Journal of biological chemistry, 2006-05, Vol.281 (18), p.12792-12798

2006

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Combined Inhibition of Gα q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma

Clinical cancer research, 2021-03, Vol.27 (5), p.1476-1490

2021

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Purinergic Receptors Crosstalk with CCR5 to Amplify Ca 2+ Signaling

Cellular and molecular neurobiology, 2021-07, Vol.41 (5), p.1085

2021

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Multiplexed mapping of the interactome of GPCRs with receptor activity–modifying proteins

Science advances, 2024-08, Vol.10 (31), p.eado9959

2024

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Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction

The FASEB journal, 2012-05, Vol.26 (5), p.2060-2071

2012

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Peptide Agonist Docking in the N-terminal Ectodomain of a Class II G Protein-coupled Receptor, the VPAC1 Receptor: PHOTOAFFINITY, NMR, AND MOLECULAR MODELING

The Journal of biological chemistry, 2006-05, Vol.281 (18), p.12792-12798

2006

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The Vasoactive Intestinal Peptide (VIP) α-Helix Up to C Terminus Interacts with the N-Terminal Ectodomain of the Human VIP/Pituitary Adenylate Cyclase-Activating Peptide 1 Receptor: Photoaffinity, Molecular Modeling, and Dynamics

Molecular endocrinology (Baltimore, Md.), 2008-01, Vol.22 (1), p.147-155

2008

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The N-Terminal Parts of VIP and Antagonist PG97–269 Physically Interact with Different Regions of the Human VPAC1 Receptor

Journal of molecular neuroscience, 2008-11, Vol.36 (1-3), p.245-248

2008

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Strategies for Studying the Ligand Binding Site of GPCRs: Photoaffinity Labeling of the VPAC1 Receptor, a Prototype of Class B GPCRs

Methods in Enzymology: G Protein Coupled Receptors: Structure, 2013, Vol.520, p.219-237

2013

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Strategies for Studying the Ligand Binding Site of GPCRs

Methods in Enzymology, 2013, Vol.520, p.219-237

2013

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The VPAC1 receptor: structure and function of a class B GPCR prototype

Frontiers in endocrinology (Lausanne), 2012, Vol.3, p.139

2012

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Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs

Purinergic Receptors Crosstalk with CCR5 to Amplify Ca2+ Signaling

Development of original metabolically stable apelin‐17 analogs with diuretic and cardiovascular effects

Multiplexed analysis of the secretin-like GPCR-RAMP interactome

Application of bioluminescence resonance energy transfer to quantitate cell-surface expression of membrane proteins

Itch receptor MRGPRX4 interacts with the receptor activity–modifying proteins

Biased Signaling Favoring Gi over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine

Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling

Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells

Abstract A07: Activating mutations in uveal melanoma convey sensitivity to g-alpha q inhibition

Peptide Agonist Docking in the N-terminal Ectodomain of a Class II G Protein-coupled Receptor, the VPAC1 Receptor

Combined Inhibition of Gα q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma

Purinergic Receptors Crosstalk with CCR5 to Amplify Ca 2+ Signaling

Multiplexed mapping of the interactome of GPCRs with receptor activity–modifying proteins

Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction

Peptide Agonist Docking in the N-terminal Ectodomain of a Class II G Protein-coupled Receptor, the VPAC1 Receptor: PHOTOAFFINITY, NMR, AND MOLECULAR MODELING

The Vasoactive Intestinal Peptide (VIP) α-Helix Up to C Terminus Interacts with the N-Terminal Ectodomain of the Human VIP/Pituitary Adenylate Cyclase-Activating Peptide 1 Receptor: Photoaffinity, Molecular Modeling, and Dynamics

The N-Terminal Parts of VIP and Antagonist PG97–269 Physically Interact with Different Regions of the Human VPAC1 Receptor

Strategies for Studying the Ligand Binding Site of GPCRs: Photoaffinity Labeling of the VPAC1 Receptor, a Prototype of Class B GPCRs

Strategies for Studying the Ligand Binding Site of GPCRs

The VPAC1 receptor: structure and function of a class B GPCR prototype

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