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Making Better Drugs: Decision Gates in Non-Clinical Drug Development

Nature reviews. Drug discovery, 2003-07, Vol.2 (7), p.542-553

2003

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Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects

Drug metabolism and disposition, 2002-04, Vol.30 (4), p.430

2002

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Early drug development: strategies and routes to first-in-human trials.

Cayen, Mitchell N

1, 2010

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Drug Metabolites in Safety Testing

Toxicology and applied pharmacology, 2002-08, Vol.182 (3), p.188-196

2002

Volltextzugriff (PDF)

Pharmacokinetics of SCH 56592, a New Azole Broad-Spectrum Antifungal Agent, in Mice, Rats, Rabbits, Dogs, and Cynomolgus Monkeys

Antimicrobial Agents and Chemotherapy, 2000-03, Vol.44 (3), p.727-731

2000

Volltextzugriff (PDF)

Bioavailability and Metabolism of Mometasone Furoate following Administration by Metered-Dose and Dry-Powder Inhalers in Healthy Human Volunteers

Journal of clinical pharmacology, 2000-11, Vol.40 (11), p.1227-1236

2000

Volltextzugriff (PDF)

The Penetration of Ceftibuten Into the Respiratory Tract

Chest, 1999-08, Vol.116 (2), p.369-374

1999

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In Vitro Uptake of SCH 27899 (Evernimicin) by Rat Alveolar Macrophages

Antimicrobial Agents and Chemotherapy, 2001-03, Vol.45 (3), p.959-961

2001

Volltextzugriff (PDF)

Considerations in the Design of Toxicokinetic Programs

Toxicologic pathology, 1995-03, Vol.23 (2), p.148-157

Cayen, Mitchell N.

1995

Volltextzugriff (PDF)

Early drug development: strategies and routes to first-in-human trials

Cayen, Mitchell N

2010

Volltextzugriff (PDF)

Characterization of AUCs from sparsely sampled populations in toxicology studies

Pharmaceutical research, 1996-09, Vol.13 (9), p.1283-1290

1996

Volltextzugriff (PDF)

Toxicokinetic Challenges in the Pharmaceutical Industry

Toxicologic pathology, 1995-03, Vol.23 (2), p.217-219

Cayen, Mitchell N.

1995

Volltextzugriff (PDF)

Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man

Pharmacology & therapeutics (Oxford), 1985, Vol.29 (2), p.157-204

Cayen, Mitchell N.

1985

Volltextzugriff (PDF)

Drug Discovery and Early Drug Development

Early Drug Development, 2010, p.1-24

Cayen, Mitchell N

2010

Volltextzugriff (PDF)

Exploratory INDs/CTAs

Early Drug Development, 2010, p.465-487

Cayen, Mitchell N

2010

Volltextzugriff (PDF)

Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Drug Discovery Today, 1999-05, Vol.4 (5), p.232-237

1999

Volltextzugriff (PDF)

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6

Biochemical pharmacology, 1996-01, Vol.51 (2), p.165-172

1996

Volltextzugriff (PDF)

Loratadine administered concomitantly with erythromycin: Pharmacokinetic and electrocardiographic evaluations

Clinical pharmacology and therapeutics, 1995-09, Vol.58 (3), p.269-278

1995

Volltextzugriff (PDF)

Synthesis and antihypertensive activity of some thienylethanolamines

Journal of medicinal chemistry, 1976-07, Vol.19 (7), p.876-882

1976

Volltextzugriff (PDF)

Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids

Journal of medicinal chemistry, 1982-10, Vol.25 (10), p.1154-1156

1982

Volltextzugriff (PDF)

Pharmacokinetics and disposition of the lipid-lowering drug acifran in normal subjects and in patients with renal failure

Clinical pharmacology and therapeutics, 1990-01, Vol.47 (1), p.50-56

1990

Volltextzugriff (PDF)

Racemic mixtures and single stereoisomers: Industrial concerns and issues in drug development

Chirality (New York, N.Y.), 1991, Vol.3 (2), p.94-98

Cayen, Mitchell N.

1991

Volltextzugriff (PDF)

Metabolic Disposition of Antihyperlipidemic Agents in Man and Laboratory Animals

Drug metabolism reviews, 1980, Vol.11 (2), p.291-323

Cayen, Mitchell N.

1980

Volltextzugriff (PDF)

Tolrestat kinetics

Clinical pharmacology and therapeutics, 1984-10, Vol.36 (4), p.493-499

1984

Volltextzugriff (PDF)

TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS

The Journal of Toxicological Sciences, 1993/11/25, Vol.18(4), pp.211-238

1993

Volltextzugriff (PDF)

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Making Better Drugs: Decision Gates in Non-Clinical Drug Development

Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects

Early drug development: strategies and routes to first-in-human trials.

Drug Metabolites in Safety Testing

Pharmacokinetics of SCH 56592, a New Azole Broad-Spectrum Antifungal Agent, in Mice, Rats, Rabbits, Dogs, and Cynomolgus Monkeys

Bioavailability and Metabolism of Mometasone Furoate following Administration by Metered-Dose and Dry-Powder Inhalers in Healthy Human Volunteers

The Penetration of Ceftibuten Into the Respiratory Tract

In Vitro Uptake of SCH 27899 (Evernimicin) by Rat Alveolar Macrophages

Considerations in the Design of Toxicokinetic Programs

Early drug development: strategies and routes to first-in-human trials

Characterization of AUCs from sparsely sampled populations in toxicology studies

Toxicokinetic Challenges in the Pharmaceutical Industry

Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man

Drug Discovery and Early Drug Development

Exploratory INDs/CTAs

Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6

Loratadine administered concomitantly with erythromycin: Pharmacokinetic and electrocardiographic evaluations

Synthesis and antihypertensive activity of some thienylethanolamines

Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids

Pharmacokinetics and disposition of the lipid-lowering drug acifran in normal subjects and in patients with renal failure

Racemic mixtures and single stereoisomers: Industrial concerns and issues in drug development

Metabolic Disposition of Antihyperlipidemic Agents in Man and Laboratory Animals

Tolrestat kinetics

TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS

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