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Clinical Pharmacokinetic and Pharmacodynamic Profile of Lacosamide

Clinical pharmacokinetics, 2015-09, Vol.54 (9), p.901-914

Cawello, Willi

2015

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Steady-State Plasma Concentration Profile of Transdermal Rotigotine: An Integrated Analysis of Three, Open-Label, Randomized, Phase I Multiple Dose Studies

Clinical therapeutics, 2012-04, Vol.34 (4), p.966-978

2012

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An Update on Pharmacological, Pharmacokinetic Properties and Drug–Drug Interactions of Rotigotine Transdermal System in Parkinson’s Disease and Restless Legs Syndrome

Drugs (New York, N.Y.), 2015-04, Vol.75 (5), p.487-501

2015

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Impact of Impaired Renal Function on the Pharmacokinetics of the Antiepileptic Drug Lacosamide

Clinical pharmacokinetics, 2013-10, Vol.52 (10), p.897-906

2013

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Clinical Pharmacokinetics of Enalapril and Enalaprilat in Pediatric Patients-A Systematic Review

Frontiers in pediatrics, 2021-02, Vol.9, p.611322

2021

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Absorption, disposition, metabolic fate, and elimination of the dopamine agonist rotigotine in man: administration by intravenous infusion or transdermal delivery

Drug metabolism and disposition, 2009-10, Vol.37 (10), p.2055-2060

2009

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Influence of Age, Heart Failure and ACE Inhibitor Treatment on Plasma Renin Activity in Children: Insights from a Systematic Review and the European LENA Project

Frontiers in bioscience (Landmark. Print), 2023-12, Vol.28 (12), p.335-335

2023

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Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)

Pharmaceutics, 2022-05, Vol.14 (6), p.1163

2022

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Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study

Contemporary clinical trials communications, 2019-09, Vol.15, p.100393-100393, Article 100393

2019

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Pharmacokinetic Properties and Tolerability of Rotigotine Transdermal Patch After Repeated-Dose Application in Healthy Korean Volunteers

Clinical therapeutics, 2015-04, Vol.37 (4), p.902-912

2015

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No Pharmacokinetic Interaction Between Lacosamide and Valproic Acid in Healthy Volunteers

Journal of clinical pharmacology, 2012-11, Vol.52 (11), p.1739-1748

2012

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Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

Frontiers in pediatrics, 2019-07, Vol.7, p.281-281

2019

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23 Plasma renin activity in young children with heart failure: influence of age, disease and ACE inhibitor treatment

Archives of disease in childhood, 2023-06, Vol.108 (6), p.A8-A8

2023

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Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers

Epilepsia (Copenhagen), 2013-03, Vol.54 (3), p.530-536

2013

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Advances in epilepsy treatment: lacosamide pharmacokinetic profile

Annals of the New York Academy of Sciences, 2014-11, Vol.1329 (1), p.18-32

2014

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Pharmacokinetics of Lacosamide in Healthy Korean Male Volunteers

Pharmacology, 2012-01, Vol.89 (3-4), p.172-178

2012

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Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration

European journal of drug metabolism and pharmacokinetics, 2012-12, Vol.37 (4), p.241-248

2012

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High Predictability of Plasma Lacosamide and No Relevant Differences by Age and Gender Following Normalization (P4.261)

Neurology, 2015-04, Vol.84 (14_supplement)

2015

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Immediate Steady-state Concentrations in Plasma after Oral or Intravenous Lacosamide Loading Dose (P4.263)

Neurology, 2015-04, Vol.84 (14_supplement)

2015

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Pharmacokinetics of Lacosamide and Omeprazole Coadministration in Healthy Volunteers: Results from a Phase I, Randomized, Crossover Trial

Clinical drug investigation, 2014-05, Vol.34 (5), p.317-325

2014

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No Pharmacokinetic Interaction Between Lacosamide and Carbamazepine in Healthy Volunteers

Journal of clinical pharmacology, 2010-04, Vol.50 (4), p.459-471

2010

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Comparison of lacosamide concentrations in cerebrospinal fluid and serum in patients with epilepsy

Epilepsia (Copenhagen), 2015-07, Vol.56 (7), p.1134-1140

2015

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A system of equations to approximate the pharmacokinetic parameters of lacosamide at steady state from one plasma sample

Epilepsy research, 2014-08, Vol.108 (6), p.1068-1075

2014

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Drug Delivery and Transport into the Central Circulation: An Example of Zero-Order In vivo Absorption of Rotigotine from a Transdermal Patch Formulation

European journal of drug metabolism and pharmacokinetics, 2018-08, Vol.43 (4), p.475-481

2018

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Tolerability, pharmacokinetics, and bioequivalence of the tablet and syrup formulations of lacosamide in plasma, saliva, and urine: Saliva as a surrogate of pharmacokinetics in the central compartment

Epilepsia (Copenhagen), 2013-01, Vol.54 (1), p.81-88

2013

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Clinical Pharmacokinetic and Pharmacodynamic Profile of Lacosamide

Steady-State Plasma Concentration Profile of Transdermal Rotigotine: An Integrated Analysis of Three, Open-Label, Randomized, Phase I Multiple Dose Studies

An Update on Pharmacological, Pharmacokinetic Properties and Drug–Drug Interactions of Rotigotine Transdermal System in Parkinson’s Disease and Restless Legs Syndrome

Impact of Impaired Renal Function on the Pharmacokinetics of the Antiepileptic Drug Lacosamide

Clinical Pharmacokinetics of Enalapril and Enalaprilat in Pediatric Patients-A Systematic Review

Absorption, disposition, metabolic fate, and elimination of the dopamine agonist rotigotine in man: administration by intravenous infusion or transdermal delivery

Influence of Age, Heart Failure and ACE Inhibitor Treatment on Plasma Renin Activity in Children: Insights from a Systematic Review and the European LENA Project

Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)

Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study

Pharmacokinetic Properties and Tolerability of Rotigotine Transdermal Patch After Repeated-Dose Application in Healthy Korean Volunteers

No Pharmacokinetic Interaction Between Lacosamide and Valproic Acid in Healthy Volunteers

Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

23 Plasma renin activity in young children with heart failure: influence of age, disease and ACE inhibitor treatment

Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers

Advances in epilepsy treatment: lacosamide pharmacokinetic profile

Pharmacokinetics of Lacosamide in Healthy Korean Male Volunteers

Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration

High Predictability of Plasma Lacosamide and No Relevant Differences by Age and Gender Following Normalization (P4.261)

Immediate Steady-state Concentrations in Plasma after Oral or Intravenous Lacosamide Loading Dose (P4.263)

Pharmacokinetics of Lacosamide and Omeprazole Coadministration in Healthy Volunteers: Results from a Phase I, Randomized, Crossover Trial

No Pharmacokinetic Interaction Between Lacosamide and Carbamazepine in Healthy Volunteers

Comparison of lacosamide concentrations in cerebrospinal fluid and serum in patients with epilepsy

A system of equations to approximate the pharmacokinetic parameters of lacosamide at steady state from one plasma sample

Drug Delivery and Transport into the Central Circulation: An Example of Zero-Order In vivo Absorption of Rotigotine from a Transdermal Patch Formulation

Tolerability, pharmacokinetics, and bioequivalence of the tablet and syrup formulations of lacosamide in plasma, saliva, and urine: Saliva as a surrogate of pharmacokinetics in the central compartment

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