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Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

Translational research : the journal of laboratory and clinical medicine, 2014-10, Vol.164 (4), p.323-335

2014

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Targeting the chemokines in cardiac repair

Current pharmaceutical design, 2014, Vol.20 (12), p.1971

2014

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Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation

American journal of physiology: endocrinology and metabolism, 2013-08, Vol.305 (3), p.E439-E450

2013

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Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice

Circulation. Heart failure, 2015-07, Vol.8 (4), p.788-798

2015

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BAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health

Scientific reports, 2024-02, Vol.14 (1), p.3838-3838

2024

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Regulation of TIMP3 in diabetic nephropathy: a role for microRNAs

Acta diabetologica, 2013-12, Vol.50 (6), p.965-969

2013

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Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6/2 mouse model of Huntington's disease

Neurobiology of disease, 2019-12, Vol.132, p.104560-104560, Article 104560

2019

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High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke

Journal of the American Heart Association, 2019-02, Vol.8 (4), p.e009874-e009874

2019

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Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice

Arteriosclerosis, thrombosis, and vascular biology, 2012-01, Vol.32 (1), p.74

2012

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Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains

Pathogens (Basel), 2024-01, Vol.13 (1), p.42

2024

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Increased whole body energy expenditure and protection against diet-induced obesity in Cyp8b1-deficient mice is accompanied by altered adipose tissue features

Adipocyte, 2020-01, Vol.9 (1), p.587-599

2020

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TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice

Molecular metabolism (Germany), 2015-10, Vol.4 (10), p.741-752

2015

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Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program

Circulation research, 2019-04, Vol.124 (8), p.1214-1227

2019

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Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events

Cardiovascular research, 2023-09, Vol.119 (11), p.2061-2073

2023

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Long‐term prevention of bladder cancer progression by alpha1‐oleate alone or in combination with chemotherapy

International journal of cancer, 2023-08, Vol.153 (3), p.584-599

2023

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Thrombospondin-1 Induction in the Diabetic Myocardium Stabilizes the Cardiac Matrix in Addition to Promoting Vascular Rarefaction Through Angiopoietin-2 Upregulation

Circulation research, 2013-12, Vol.113 (12), p.1331-1344

2013

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sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events

Stroke (1970), 2019-08, Vol.50 (8), p.1989-1996

2019

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The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death

Atherosclerosis, 2020-11, Vol.313, p.88-95

2020

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Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue

Nutrition & metabolism, 2016-12, Vol.13 (1), p.91-91, Article 91

2016

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Dietary rose hip exerts antiatherosclerotic effects and increases nitric oxide-mediated dilation in ApoE-null mice

The Journal of nutritional biochemistry, 2017-06, Vol.44, p.52-59

2017

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Peptide-Oleate Complexes Create Novel Membrane-Bound Compartments

Molecular biology and evolution, 2020-11, Vol.37 (11), p.3083-3093

2020

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Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice

Atherosclerosis, 2014-08, Vol.235 (2), p.438-443

2014

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Soluble TRAIL-R2 a marker of plaque cell apoptosis and cardiovascular events

Stroke (1970), 2019-05, Vol.50 (8), p.1989

2019

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Increased tumor necrosis factor α–converting enzyme activity induces insulin resistance and hepatosteatosis in mice

Hepatology (Baltimore, Md.), 2010-01, Vol.51 (1), p.103-110

2010

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Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

EMBO molecular medicine, 2013-03, Vol.5 (3), p.441-455

2013

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Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

Targeting the chemokines in cardiac repair

Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation

Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice

BAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health

Regulation of TIMP3 in diabetic nephropathy: a role for microRNAs

Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6/2 mouse model of Huntington's disease

High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke

Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice

Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains

Increased whole body energy expenditure and protection against diet-induced obesity in Cyp8b1-deficient mice is accompanied by altered adipose tissue features

TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice

Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program

Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events

Long‐term prevention of bladder cancer progression by alpha1‐oleate alone or in combination with chemotherapy

Thrombospondin-1 Induction in the Diabetic Myocardium Stabilizes the Cardiac Matrix in Addition to Promoting Vascular Rarefaction Through Angiopoietin-2 Upregulation

sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events

The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death

Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue

Dietary rose hip exerts antiatherosclerotic effects and increases nitric oxide-mediated dilation in ApoE-null mice

Peptide-Oleate Complexes Create Novel Membrane-Bound Compartments

Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice

Soluble TRAIL-R2 a marker of plaque cell apoptosis and cardiovascular events

Increased tumor necrosis factor α–converting enzyme activity induces insulin resistance and hepatosteatosis in mice

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

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