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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Nature reviews. Neurology, 2019-09, Vol.15 (9), p.501-518

2019

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FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Nature communications, 2020-03, Vol.11 (1), p.1318-1318, Article 1318

2020

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PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?

Journal of Parkinson's disease, 2017-01, Vol.7 (1), p.13-29

2017

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Activation of the E3 ubiquitin ligase Parkin

Biochemical Society transactions, 2015-04, Vol.43 (2), p.269-274

2015

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Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

Nature communications, 2023-05, Vol.14 (1), p.2558-2558, Article 2558

2023

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Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin

PLoS computational biology, 2014-11, Vol.10 (11), p.e1003935-e1003935

2014

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Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer

Nanoscale, 2019-11, Vol.11 (45), p.226-2218

2019

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Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

Clinical cancer research, 2013-05, Vol.19 (9), p.2368-2380

2013

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Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

Cell reports (Cambridge), 2018-07, Vol.24 (3), p.529-537.e4

2018

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Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Scientific reports, 2023-03, Vol.13 (1), p.5186-5186, Article 5186

2023

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Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7151

2023

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Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Human mutation, 2015-08, Vol.36 (8), p.774-786

2015

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Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency

Human molecular genetics, 2014-03, Vol.23 (6), p.1467-1478

2014

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A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells

Frontiers in cellular neuroscience, 2024-07, Vol.18, p.1368018

2024

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Inter-ring rotation of apolipoprotein A-I protein monomers for the double-belt model using biased molecular dynamics

Journal of molecular graphics & modelling, 2011-08, Vol.29 (8), p.1006-1014

Caulfield, Thomas R.

2011

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The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Molecular neurodegeneration, 2017-04, Vol.12 (1), p.32-32, Article 32

2017

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Small molecule inhibitors of mesotrypsin from a structure-based docking screen

PloS one, 2017-05, Vol.12 (5), p.e0176694

2017

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Structural And Computational Perspectives of Selectively Targeting Mutant Proteins

Current drug discovery technologies, 2021, Vol.18 (3), p.365-378

2021

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In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling

Biomolecules (Basel, Switzerland), 2024-03, Vol.14 (3), p.365

2024

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Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

The Journal of biological chemistry, 2013-04, Vol.288 (14), p.9848-9859

2013

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Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement

Biomolecules (Basel, Switzerland), 2021-05, Vol.11 (6), p.787

2021

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Decoding Immuno-Competence: A Novel Analysis of Complete Blood Cell Count Data in COVID-19 Outcomes

Biomedicines, 2024-04, Vol.12 (4), p.871

2024

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Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics

Molecular aspects of medicine, 2023-06, Vol.91, p.101153-101153, Article 101153

2023

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Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

ACS chemical biology, 2015-12, Vol.10 (12), p.2716-2724

2015

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Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W

Cells (Basel, Switzerland), 2024-09, Vol.13 (18), p.1540

2024

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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?

Activation of the E3 ubiquitin ligase Parkin

Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin

Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency

A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells

Inter-ring rotation of apolipoprotein A-I protein monomers for the double-belt model using biased molecular dynamics

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Small molecule inhibitors of mesotrypsin from a structure-based docking screen

Structural And Computational Perspectives of Selectively Targeting Mutant Proteins

In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling

Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement

Decoding Immuno-Competence: A Novel Analysis of Complete Blood Cell Count Data in COVID-19 Outcomes

Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W

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