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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Nature reviews. Neurology, 2019-09, Vol.15 (9), p.501

2019

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Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer

Nanoscale, 2019-11, Vol.11 (45), p.226-2218

2019

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Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin

PLoS computational biology, 2014-11, Vol.10 (11), p.e1003935-e1003935

2014

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FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Nature communications, 2020-03, Vol.11 (1), p.1318-1318, Article 1318

2020

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PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?

Journal of Parkinson's disease, 2017-01, Vol.7 (1), p.13

2017

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Activation of the E3 ubiquitin ligase Parkin

Biochemical Society transactions, 2015-04, Vol.43 (2), p.269

2015

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Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

Nature communications, 2023-05, Vol.14 (1), p.2558-2558, Article 2558

2023

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Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

Clinical cancer research, 2013-05, Vol.19 (9), p.2368-2380

2013

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Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

Cell reports (Cambridge), 2018-07, Vol.24 (3), p.529-537.e4

2018

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Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Scientific reports, 2023-03, Vol.13 (1), p.5186-5186, Article 5186

2023

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Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency

Human molecular genetics, 2014-03, Vol.23 (6), p.1467-1478

2014

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Understanding the needs and preferences for cancer care among First Nations people: An integrative review

Journal of advanced nursing, 2024-05, Vol.80 (5), p.1776-1812

2024

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Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7151

2023

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Fatty Acid Composition, Phospholipid Molecules, and Bioactivities of Lipids of the Mud Crab Scylla paramamosain

Journal of chemistry, 2020, Vol.2020, p.1-9

2020

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A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells

Frontiers in cellular neuroscience, 2024-07, Vol.18, p.1368018

2024

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Inter-ring rotation of apolipoprotein A-I protein monomers for the double-belt model using biased molecular dynamics

Journal of molecular graphics & modelling, 2011-08, Vol.29 (8), p.1006-1014

Caulfield, Thomas R.

2011

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Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Human mutation, 2015-08, Vol.36 (8), p.774-786

2015

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Small molecule inhibitors of mesotrypsin from a structure-based docking screen

PloS one, 2017-05, Vol.12 (5), p.e0176694

2017

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The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Molecular neurodegeneration, 2017-04, Vol.12 (1), p.32-32, Article 32

2017

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Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering

Journal of chemistry, 2020, Vol.2020, p.1-7

2020

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Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

Chemical biology & drug design, 2015-11, Vol.86 (5), p.1036-1048

2015

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Agave Leaves as a Substrate for the Production of Cellulases by Penicillium sp. and the Obtainment of Reducing Sugars

Journal of chemistry, 2020, Vol.2020, p.1-7

2020

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In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling

Biomolecules (Basel, Switzerland), 2024-03, Vol.14 (3), p.365

2024

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Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

The Journal of biological chemistry, 2013-04, Vol.288 (14), p.9848-9859

2013

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A Synthetic Pan-Aurora Kinase Inhibitor, 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one, Triggers Reactive Oxygen Species-Mediated Apoptosis in HCT116 Colon Cancer Cells

Journal of chemistry, 2020, Vol.2020, p.1-11

2020

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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer

Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?

Activation of the E3 ubiquitin ligase Parkin

Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency

Understanding the needs and preferences for cancer care among First Nations people: An integrative review

Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure

Fatty Acid Composition, Phospholipid Molecules, and Bioactivities of Lipids of the Mud Crab Scylla paramamosain

A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells

Inter-ring rotation of apolipoprotein A-I protein monomers for the double-belt model using biased molecular dynamics

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Small molecule inhibitors of mesotrypsin from a structure-based docking screen

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering

Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

Agave Leaves as a Substrate for the Production of Cellulases by Penicillium sp. and the Obtainment of Reducing Sugars

In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling

Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

A Synthetic Pan-Aurora Kinase Inhibitor, 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one, Triggers Reactive Oxygen Species-Mediated Apoptosis in HCT116 Colon Cancer Cells

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