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Polygenic risk scores: from research tools to clinical instruments

Genome medicine, 2020-05, Vol.12 (1), p.44-44, Article 44

2020

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PRSice: Polygenic Risk Score software

Bioinformatics, 2015-05, Vol.31 (9), p.1466-1468

2015

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Prospects for using risk scores in polygenic medicine

Genome medicine, 2017-11, Vol.9 (1), p.96-96, Article 96

2017

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Cross-classification between self-rated health and health status: longitudinal analyses of all-cause mortality and leading causes of death in the UK

Scientific reports, 2022-01, Vol.12 (1), p.459-459, Article 459

2022

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Evaluation of polygenic prediction methodology within a reference-standardized framework

PLoS genetics, 2021-05, Vol.17 (5), p.e1009021-e1009021

2021

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Uncovering the Genetic Architecture of Major Depression

Neuron (Cambridge, Mass.), 2019-04, Vol.102 (1), p.91-103

2019

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Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

Nature communications, 2020-05, Vol.11 (1), p.2175-2175, Article 2175

2020

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A bidirectional relationship between depression and the autoimmune disorders - New perspectives from the National Child Development Study

PloS one, 2017-03, Vol.12 (3), p.e0173015-e0173015

2017

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Exploring health in the UK Biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures

BMC medicine, 2021-10, Vol.19 (1), p.240-18, Article 240

2021

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Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism

Nature genetics, 2018-01, Vol.50 (1), p.6-11

2018

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Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

Lancet neurology, 2021-05, Vol.20 (5), p.351-361

2021

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Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

Molecular psychiatry, 2021-07, Vol.26 (7), p.3363-3373

2021

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Examining the association between family status and depression in the UK Biobank

Journal of affective disorders, 2021-01, Vol.279, p.585-598

2021

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Contribution of Common Genetic Variants to Antidepressant Response

Biological psychiatry (1969), 2013-04, Vol.73 (7), p.679-682

2013

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Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders

Genome Biology, 2018-11, Vol.19 (1), p.194-194, Article 194

2018

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Combining clinical variables to optimize prediction of antidepressant treatment outcomes

Journal of psychiatric research, 2016-07, Vol.78, p.94-102

2016

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Comorbid medical illness in bipolar disorder

British journal of psychiatry, 2014-12, Vol.205 (6), p.465-472

2014

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Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke

Nature communications, 2022-10, Vol.13 (1), p.6143-6143, Article 6143

2022

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ukbtools: An R package to manage and query UK Biobank data

PloS one, 2019-05, Vol.14 (5), p.e0214311-e0214311

2019

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Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach

PloS one, 2023-11, Vol.18 (11), p.e0294045-e0294045

2023

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Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations

Genome medicine, 2024-08, Vol.16 (1), p.106-17

2024

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Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study

PLoS medicine, 2020-06, Vol.17 (6), p.e1003137

2020

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Impute.me: An Open-Source, Non-profit Tool for Using Data From Direct-to-Consumer Genetic Testing to Calculate and Interpret Polygenic Risk Scores

Frontiers in genetics, 2020-06, Vol.11, p.578

2020

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Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts

PloS one, 2018-09, Vol.13 (9), p.e0203896

2018

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From SNPs to genes: disease association at the gene level

PloS one, 2011-06, Vol.6 (6), p.e20133-e20133

2011

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Polygenic risk scores: from research tools to clinical instruments

PRSice: Polygenic Risk Score software

Prospects for using risk scores in polygenic medicine

Cross-classification between self-rated health and health status: longitudinal analyses of all-cause mortality and leading causes of death in the UK

Evaluation of polygenic prediction methodology within a reference-standardized framework

Uncovering the Genetic Architecture of Major Depression

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

A bidirectional relationship between depression and the autoimmune disorders - New perspectives from the National Child Development Study

Exploring health in the UK Biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism

Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

Examining the association between family status and depression in the UK Biobank

Contribution of Common Genetic Variants to Antidepressant Response

Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders

Combining clinical variables to optimize prediction of antidepressant treatment outcomes

Comorbid medical illness in bipolar disorder

Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke

ukbtools: An R package to manage and query UK Biobank data

Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach

Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations

Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study

Impute.me: An Open-Source, Non-profit Tool for Using Data From Direct-to-Consumer Genetic Testing to Calculate and Interpret Polygenic Risk Scores

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts

From SNPs to genes: disease association at the gene level

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