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Alzheimer's-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (4), p.1630-1635

2010

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Microarray Analysis of Hippocampal CA1 Neurons Implicates Early Endosomal Dysfunction During Alzheimer's Disease Progression

Biological psychiatry (1969), 2010-11, Vol.68 (10), p.885-893

2010

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Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease

The American journal of pathology, 2008-09, Vol.173 (3), p.665-681

2008

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Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression

The Journal of neuroscience, 2008-11, Vol.28 (47), p.12241-12254

2008

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Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model

Journal of neurochemistry, 2009-09, Vol.110 (6), p.1818-1827

2009

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Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology

Journal of neuropathology and experimental neurology, 2004-08, Vol.63 (8), p.821-830

2004

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Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons

Cell reports (Cambridge), 2021-04, Vol.35 (4), p.109034-109034, Article 109034

2021

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Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

The American journal of pathology, 2010-08, Vol.177 (2), p.575-585

2010

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Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease

Journal of Alzheimer's disease, 2006-01, Vol.9 (3 Suppl), p.277-289

2006

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Macroautophagy: A Novel β-Amyloid Peptide-Generating Pathway Activated in Alzheimer's Disease

The Journal of cell biology, 2005-10, Vol.171 (1), p.87-98

2005

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Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology: Accelerated Endocytosis Promotes Late Endocytic Defects

The American journal of pathology, 2008-08, Vol.173 (2), p.370-384

2008

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Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down syndrome

Neurobiology of aging, 2004-11, Vol.25 (10), p.1263-1272

2004

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Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

Neuron (Cambridge, Mass.), 1995-03, Vol.14 (3), p.671-680

1995

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Detection of Intranasally Delivered Bone Marrow-Derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain : A Cautionary Report

Stem cells international, 2011-01, Vol.2011 (2011), p.1-12

2011

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App Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome

The Journal of neuroscience, 2003-07, Vol.23 (17), p.6788-6792

2003

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The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis : A review

Neurochemical research, 2000-10, Vol.25 (9-10), p.1161-1172

2000

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Rab5 Mediates an Amyloid Precursor Protein Signaling Pathway That Leads to Apoptosis

The Journal of neuroscience, 2007-07, Vol.27 (27), p.7141-7153

2007

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Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer's Disease: Neuropathologic Evidence for a Mechanism of Increased beta -Amyloidogenesis

The Journal of neuroscience, 1997-08, Vol.17 (16), p.6142-6151

1997

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In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model

Neurobiology of aging, 2009-09, Vol.30 (9), p.1453-1465

2009

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The neuronal endosomal-lysosomal system in Alzheimer's disease

Journal of Alzheimer's disease, 2001-02, Vol.3 (1), p.97-107

2001

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The endosomal-lysosomal system of neurons: new roles

Trends in Neurosciences, 1995-11, Vol.18 (11), p.489-496

1995

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Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology

The American journal of pathology, 2008, Vol.173 (2), p.370-384

2008

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Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations

The American journal of pathology, 2000-07, Vol.157 (1), p.277-286

2000

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Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular β-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and Aβ Production

The Journal of biological chemistry, 2003-08, Vol.278 (33), p.31261-31268

2003

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Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections

Brain research. Brain research protocols, 1998, Vol.2 (2), p.109-119

1998

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Alzheimer's-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition

Microarray Analysis of Hippocampal CA1 Neurons Implicates Early Endosomal Dysfunction During Alzheimer's Disease Progression

Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease

Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model

Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology

Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons

Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease

Macroautophagy: A Novel β-Amyloid Peptide-Generating Pathway Activated in Alzheimer's Disease

Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology: Accelerated Endocytosis Promotes Late Endocytic Defects

Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down syndrome

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

Detection of Intranasally Delivered Bone Marrow-Derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain : A Cautionary Report

App Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis : A review

Rab5 Mediates an Amyloid Precursor Protein Signaling Pathway That Leads to Apoptosis

Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer's Disease: Neuropathologic Evidence for a Mechanism of Increased beta -Amyloidogenesis

In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model

The neuronal endosomal-lysosomal system in Alzheimer's disease

The endosomal-lysosomal system of neurons: new roles

Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology

Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations

Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular β-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and Aβ Production

Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections

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