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The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics

Frontiers in pharmacology, 2023-05, Vol.14, p.1155271-1155271

2023

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Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways

Food and chemical toxicology, 2021-12, Vol.158, p.112664-112664, Article 112664

2021

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Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved

Archives of toxicology, 2023-06, Vol.97 (6), p.1723-1738

2023

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The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment

Metabolites, 2022-06, Vol.12 (6), p.564

2022

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A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes

Journal of proteome research, 2022-03, Vol.21 (3), p.702-712

2022

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A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

Frontiers in physiology, 2019-09, Vol.10, p.1192-1192

2019

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Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat

International journal of molecular sciences, 2022-08, Vol.23 (16), p.9298

2022

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Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

Chemico-biological interactions, 2010-03, Vol.184 (3), p.376-387

2010

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New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

Frontiers in pharmacology, 2017-01, Vol.8, p.3-3

2017

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Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes

Drug metabolism and disposition, 2004-07, Vol.32 (7), p.699

2004

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Down‐regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factors involved

The FASEB journal, 2002-11, Vol.16 (13), p.1-29

2002

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Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC–MS Metabolomics

Metabolites, 2020-03, Vol.10 (4), p.126

2020

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CCAAT/Enhancer-binding Protein α (C/EBPα) and Hepatocyte Nuclear Factor 4α (HNF4α) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene: APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL

The Journal of biological chemistry, 2010-09, Vol.285 (37), p.28457-28471

2010

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The use of hepatocytes to investigate drug toxicity

Methods in molecular biology (Clifton, N.J.), 2010-01, Vol.640, p.389

2010

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A score model for the continuous grading of early allograft dysfunction severity

Liver transplantation, 2015-01, Vol.21 (1), p.38-46

2015

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Underexpressed Coactivators PGC1α AND SRC1 Impair Hepatocyte Nuclear Factor 4α Function and Promote Dedifferentiation in Human Hepatoma Cells

The Journal of biological chemistry, 2006-10, Vol.281 (40), p.29840-29849

2006

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Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

Journal of lipid research, 2012-10, Vol.53 (10), p.2231-2241

2012

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Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS

Biochemical pharmacology, 2003-12, Vol.66 (11), p.2155-2167

2003

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ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses

Drug metabolism and disposition, 2008-06, Vol.36 (6), p.1063

2008

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An update on metabolism studies using human hepatocytes in primary culture

Expert opinion on drug metabolism & toxicology, 2008-07, Vol.4 (7), p.837-854

2008

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Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach

Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2005-07, Vol.57, p.189-204

2005

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Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches

Toxicology (Amsterdam), 2024-05, Vol.504, p.153764-153764, Article 153764

2024

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Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis

Scientific reports, 2019-07, Vol.9 (1), p.9822-9, Article 9822

2019

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Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis

International journal of molecular sciences, 2024-03, Vol.25 (5), p.3003

2024

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A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations

Journal of proteome research, 2011-10, Vol.10 (10), p.4825-4834

2011

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The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics

Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways

Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved

The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment

A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes

A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat

Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes

Down‐regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factors involved

Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC–MS Metabolomics

CCAAT/Enhancer-binding Protein α (C/EBPα) and Hepatocyte Nuclear Factor 4α (HNF4α) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene: APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL

The use of hepatocytes to investigate drug toxicity

A score model for the continuous grading of early allograft dysfunction severity

Underexpressed Coactivators PGC1α AND SRC1 Impair Hepatocyte Nuclear Factor 4α Function and Promote Dedifferentiation in Human Hepatoma Cells

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS

ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses

An update on metabolism studies using human hepatocytes in primary culture

Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach

Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches

Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis

Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis

A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations

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