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A New ABC Half-Transporter in Leishmania major Is Involved in Resistance to Antimony

Antimicrobial Agents and Chemotherapy, 2013-08, Vol.57 (8), p.3719-3730

2013

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High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease

Journal of biomolecular screening, 2015-01, Vol.20 (1), p.82-91

2015

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Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use

Drug resistance updates, 2006-02, Vol.9 (1), p.26-39

2006

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Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters

Cellular and molecular life sciences : CMLS, 2002-02, Vol.59 (2), p.307-322

2002

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Dihidro-β-Agarofuran Sesquiterpenes: A New Class of Reversal Agents of the Multidrug Resistance Phenotype Mediated by P-Glycoprotein in the Protozoan Parasite Leishmania

Current pharmaceutical design, 2005-09, Vol.11 (24), p.3125-3139

2005

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Alkyl-Lysophospholipid Resistance in Multidrug-Resistant Leishmania tropica and Chemosensitization by a Novel P-Glycoprotein-Like Transporter Modulator

Antimicrobial Agents and Chemotherapy, 2001-09, Vol.45 (9), p.2468-2474

2001

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Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents

Current drug targets, 2002-08, Vol.3 (4), p.311-333

2002

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Chemosensitization of a Multidrug-Resistant Leishmania tropica Line by New Sesquiterpenes from Maytenus magellanica and Maytenus chubutensis

Journal of medicinal chemistry, 2001-12, Vol.44 (26), p.4668-4676

2001

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Correlation between the Affinity of Flavonoids Binding to the Cytosolic Site of Leishmania tropica Multidrug Transporter and Their Efficiency To Revert Parasite Resistance to Daunomycin

Biochemistry (Easton), 1999-02, Vol.38 (6), p.1736-1743

1999

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High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin

Antimicrobial agents and chemotherapy, 2001-02, Vol.45 (2), p.439-446

2001

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Leishmania donovani Resistance to Miltefosine Involves a Defective Inward Translocation of the Drug

Antimicrobial Agents and Chemotherapy, 2003-08, Vol.47 (8), p.2397-2403

2003

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Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2

Cancer research (Chicago, Ill.), 2005-06, Vol.65 (11), p.4852-4860

2005

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Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

The Journal of biological chemistry, 2003-12, Vol.278 (50), p.49965-49971

2003

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RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance

Cellular and molecular life sciences : CMLS, 2003-03, Vol.60 (3), p.526-535

2003

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Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

Journal of antimicrobial chemotherapy, 2014-03, Vol.69 (3), p.664-672

2014

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Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi

Molecular and biochemical parasitology, 1996-01, Vol.75 (2), p.145-157

1996

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Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)

International journal of antimicrobial agents, 2003-10, Vol.22 (4), p.380-387

2003

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Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania

Journal of antimicrobial chemotherapy, 2011-11, Vol.66 (11), p.2562-2565

2011

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Combination of Suboptimal Doses of Inhibitors Targeting Different Domains of LtrMDR1 Efficiently Overcomes Resistance of Leishmania spp. to Miltefosine by Inhibiting Drug Efflux

Antimicrobial Agents and Chemotherapy, 2006-09, Vol.50 (9), p.3102-3110

2006

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Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance

Cancer research (Chicago, Ill.), 2004-10, Vol.64 (19), p.7130-7138

2004

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Increased P-Type ATPase Activity in Leishmania tropica Resistant to Methotrexate

Biochemical and biophysical research communications, 1994-03, Vol.199 (2), p.855-861

1994

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Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis

Journal of medicinal chemistry, 2005-06, Vol.48 (13), p.4266-4275

2005

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The overexpression of an intracellular ABCA-like transporter alters phospholipid trafficking in Leishmania

Biochemical and biophysical research communications, 2005-04, Vol.330 (1), p.349-355

2005

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The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity

Biochimica et biophysica acta, 2003-06, Vol.1612 (2), p.195-207

2003

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Trypanosoma cruzi: Sequence of the ATP-Binding Site of a P-Glycoprotein Gene

Experimental parasitology, 1994-08, Vol.79 (1), p.63-67

1994

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A New ABC Half-Transporter in Leishmania major Is Involved in Resistance to Antimony

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters

Dihidro-β-Agarofuran Sesquiterpenes: A New Class of Reversal Agents of the Multidrug Resistance Phenotype Mediated by P-Glycoprotein in the Protozoan Parasite Leishmania

Alkyl-Lysophospholipid Resistance in Multidrug-Resistant Leishmania tropica and Chemosensitization by a Novel P-Glycoprotein-Like Transporter Modulator

Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents

Chemosensitization of a Multidrug-Resistant Leishmania tropica Line by New Sesquiterpenes from Maytenus magellanica and Maytenus chubutensis

Correlation between the Affinity of Flavonoids Binding to the Cytosolic Site of Leishmania tropica Multidrug Transporter and Their Efficiency To Revert Parasite Resistance to Daunomycin

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin

Leishmania donovani Resistance to Miltefosine Involves a Defective Inward Translocation of the Drug

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania

Combination of Suboptimal Doses of Inhibitors Targeting Different Domains of LtrMDR1 Efficiently Overcomes Resistance of Leishmania spp. to Miltefosine by Inhibiting Drug Efflux

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance

Increased P-Type ATPase Activity in Leishmania tropica Resistant to Methotrexate

Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis

The overexpression of an intracellular ABCA-like transporter alters phospholipid trafficking in Leishmania

The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity

Trypanosoma cruzi: Sequence of the ATP-Binding Site of a P-Glycoprotein Gene

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