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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1

PloS one, 2021-06, Vol.16 (6), p.e0251955

2021

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Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation

Nature communications, 2023-08, Vol.14 (1), p.4480-20, Article 4480

2023

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A high-throughput screening assay for silencing established HIV-1 macrophage infection identifies nucleoside analogs that perturb H3K9me3 on proviral genomes

Journal of virology, 2023-08, Vol.97 (8), p.e0065323-e0065323

2023

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Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: Characterization of inhibition by nucleic acids and 4-aminoquinolines

Biochimica et biophysica acta, 2013-06, Vol.1834 (6), p.964-971

2013

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Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth

Science translational medicine, 2019-03, Vol.11 (482)

2019

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A homogeneous time-resolved fluorescence screen to identify SIRT2 deacetylase and defatty-acylase inhibitors

PloS one, 2024-06, Vol.19 (6), p.e0305000

2024

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The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

Antimicrobial agents and chemotherapy, 2021-11, Vol.65 (12), p.e0077221-e0077221

2021

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Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Human molecular genetics, 2015-12, Vol.24 (24), p.6886-6898

2015

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Metabolomic Analysis and Antiviral Screening of a Marine Algae Library Yield Jobosic Acid (2,5-Dimethyltetradecanoic Acid) as a Selective Inhibitor of SARS-CoV‑2

Journal of natural products (Washington, D.C.), 2024-06, Vol.87 (6), p.1513-1520

2024

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A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

Cancer research (Chicago, Ill.), 2020-12, Vol.80 (23), p.5270-5281

2020

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Computer-aided design, synthesis, and biological evaluation of 4-chloro-N-(2-oxo-3-(2-pyridin-4-yl)hydrazineylidene)indolin-5yl)benzamide and 1-(4-bromobenzyl)-5-indoline-2,3-dione against SARS-CoV-2 spike/ACE2

The Microbe, 2024-09, Vol.4, p.100143, Article 100143

2024

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Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ

Bioorganic & medicinal chemistry, 2012-06, Vol.20 (11), p.3609-3614

2012

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Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs

Viruses, 2021-02, Vol.13 (2), p.288

2021

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Investigation of some plant stilbenoids and their fragments for the identification of inhibitors of SARS-CoV-2 viral spike/ACE2 protein binding

The Microbe, 2024-06, Vol.3, p.100059, Article 100059

2024

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Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Journal of medicinal chemistry, 2008-10, Vol.51 (19), p.5893-5896

2008

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Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function

Biochimie, 2012-09, Vol.94 (9), p.1974-1981

2012

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Current nervous system related drug targets for the treatment of amyotrophic lateral sclerosis

Current pharmaceutical design, 2010-06, Vol.16 (18), p.2053-2073

2010

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In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme

Molecular therapy. Oncolytics, 2022-09, Vol.26, p.289-301

2022

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Development of a Novel Nonradiometric Assay for Nucleic Acid Binding to TDP-43 Suitable for High-Throughput Screening Using AlphaScreen® Technology

Journal of biomolecular screening, 2010-10, Vol.15 (9), p.1099-1106

2010

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[3H]Alvimopan binding to the μ opioid receptor: Comparative binding kinetics of opioid antagonists

European journal of pharmacology, 2005-09, Vol.520 (1-3), p.29-36

2005

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Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Journal of medicinal chemistry, 2009-09, Vol.52 (18), p.5685-5702

2009

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Synthesis and Biological Activities of Cyclic Lanthionine Enkephalin Analogues: δ-Opioid Receptor Selective Ligands

Journal of medicinal chemistry, 2002-08, Vol.45 (17), p.3746-3754

2002

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Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5931-5935

2009

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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1

Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation

A high-throughput screening assay for silencing established HIV-1 macrophage infection identifies nucleoside analogs that perturb H3K9me3 on proviral genomes

Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: Characterization of inhibition by nucleic acids and 4-aminoquinolines

Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth

A homogeneous time-resolved fluorescence screen to identify SIRT2 deacetylase and defatty-acylase inhibitors

The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Metabolomic Analysis and Antiviral Screening of a Marine Algae Library Yield Jobosic Acid (2,5-Dimethyltetradecanoic Acid) as a Selective Inhibitor of SARS-CoV‑2

A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Computer-aided design, synthesis, and biological evaluation of 4-chloro-N-(2-oxo-3-(2-pyridin-4-yl)hydrazineylidene)indolin-5yl)benzamide and 1-(4-bromobenzyl)-5-indoline-2,3-dione against SARS-CoV-2 spike/ACE2

Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ

Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs

Investigation of some plant stilbenoids and their fragments for the identification of inhibitors of SARS-CoV-2 viral spike/ACE2 protein binding

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function

Current nervous system related drug targets for the treatment of amyotrophic lateral sclerosis

In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme

Immune Responses of a Novel Bi-Cistronic SARS-CoV-2 DNA Vaccine Following Intradermal Immunization With Suction Delivery

Development of a Novel Nonradiometric Assay for Nucleic Acid Binding to TDP-43 Suitable for High-Throughput Screening Using AlphaScreen® Technology

[3H]Alvimopan binding to the μ opioid receptor: Comparative binding kinetics of opioid antagonists

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Synthesis and Biological Activities of Cyclic Lanthionine Enkephalin Analogues: δ-Opioid Receptor Selective Ligands

Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists

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