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High-Throughput Cryo-EM Enabled by User-Free Preprocessing Routines

Structure (London), 2020-07, Vol.28 (7), p.858-869.e3

2020

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Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

PLoS biology, 2020-12, Vol.18 (12), p.e3001018-e3001018

2020

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Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3

Structure (London), 2016-05, Vol.24 (5), p.730-740

2016

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Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

eLife, 2024-07, Vol.12

2024

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High-resolution cryo-EM using beam-image shift at 200 keV

IUCrJ, 2020-11, Vol.7 (Pt 6), p.1179-1187

2020

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Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold

Science advances, 2019-10, Vol.5 (10), p.eaax8855-eaax8855

2019

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Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3

Journal of structural biology. X, 2019-01, Vol.1 (C), p.100001-100001, Article 100001

2019

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New insights into regulation of P‐Rex1 autoinhibition

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102209-102209, Article 102209

2022

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The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

The Journal of biological chemistry, 2020-09, Vol.295 (36), p.12635-12647

2020

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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

Molecular pharmacology, 2020-03, Vol.97 (3), p.226-236

2020

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The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

The EMBO journal, 2009-09, Vol.28 (17), p.2662-2676

2009

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Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding

The Journal of biological chemistry, 2012-01, Vol.287 (2), p.1043-1053

2012

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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP 3 )-Dependent Rac Exchanger 1 (P-Rex1) PIP 3 -Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils

Molecular pharmacology, 2020-03, Vol.97 (3), p.226-236

2020

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Characterization of Follistatin-Type Domains and Their Contribution to Myostatin and Activin A Antagonism

Molecular endocrinology (Baltimore, Md.), 2012-07, Vol.26 (7), p.1167-1178

2012

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Structural Snapshots of a Dynamic Process in the Regulation of P-Rex, a Metastatic Factor

Microscopy and microanalysis, 2018-08, Vol.24 (S1), p.1218-1219

2018

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Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A

Journal of biomolecular screening, 2013-08, Vol.18 (7), p.837-844

2013

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Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

eLife, 2024-07, Vol.12

2024

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Structural and Functional Characterization of the Metastatic RhoGEF P‐Rex1 and its Regulation by PtdIns(3,4,5) P 3 : Towards Inhibitory Small Molecule Development

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P[subscript 3]

Structure (London), 2016-06, Vol.24 ((5) ; 05, 2016)

2016

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Discovery and Assessment of Chemical Probes Targeting Regulatory Surfaces of P‐Rex1, a Metastatic RhoGEF

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Structural analyses of the PKA RII[beta] holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

PLoS biology, 2020-12, Vol.18 (12)

2020

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Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4

eLife, 2024-07, Vol.12

2024

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Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP 3

Journal of structural biology. X, 2019-01, Vol.1, p.100001

2019

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Structure of Myostatin·Follistatin-like 3

The Journal of biological chemistry, 2012-01, Vol.287 (2), p.1043-1053

2012

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High-Throughput Cryo-EM Enabled by User-Free Preprocessing Routines

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

High-resolution cryo-EM using beam-image shift at 200 keV

Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold

Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3

New insights into regulation of P‐Rex1 autoinhibition

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP 3 )-Dependent Rac Exchanger 1 (P-Rex1) PIP 3 -Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils

Characterization of Follistatin-Type Domains and Their Contribution to Myostatin and Activin A Antagonism

Structural Snapshots of a Dynamic Process in the Regulation of P-Rex, a Metastatic Factor

Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

Structural and Functional Characterization of the Metastatic RhoGEF P‐Rex1 and its Regulation by PtdIns(3,4,5) P 3 : Towards Inhibitory Small Molecule Development

Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P[subscript 3]

Discovery and Assessment of Chemical Probes Targeting Regulatory Surfaces of P‐Rex1, a Metastatic RhoGEF

Structural analyses of the PKA RII[beta] holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4

Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP 3

Structure of Myostatin·Follistatin-like 3

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