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Opinion: Post-prenylation-processing enzymes as new targets in oncogenesis

Nature reviews. Cancer, 2005-05, Vol.5 (5), p.405

2005

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Biochemistry of protein prenylation

Journal of lipid research, 1992-12, Vol.33 (12), p.1731-1740

Casey, PJ

1992

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Crystallographic Analysis of CaaX Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity

Journal of molecular biology, 2004-10, Vol.343 (2), p.417-433

2004

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Protein Lipidation in Cell Signaling

Science (American Association for the Advancement of Science), 1995-04, Vol.268 (5208), p.221-225

Casey, Patrick J.

1995

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Rap1 GTPase Inhibits Leukocyte Transmigration by Promoting Endothelial Barrier Function

The Journal of biological chemistry, 2005-03, Vol.280 (12), p.11675-11682

2005

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Protein Prenylation: Molecular Mechanisms and Functional Consequences

Annual review of biochemistry, 1996-01, Vol.65 (1), p.241-269

1996

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Protein Prenyltransferases (∗)

The Journal of biological chemistry, 1996-03, Vol.271 (10), p.5289-5292

1996

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Reaction path of protein farnesyltransferase at atomic resolution

Nature (London), 2002-10, Vol.419 (6907), p.645-650

2002

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A Small-Molecule Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase with Antitumor Activity in Cancer Cells

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (12), p.4336-4341

2005

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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

The Journal of clinical investigation, 2004-02, Vol.113 (4), p.539-550

2004

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Involvement of a Mitochondrial Phosphatase in the Regulation of ATP Production and Insulin Secretion in Pancreatic β Cells

Molecular cell, 2005-07, Vol.19 (2), p.197-207

2005

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Identification of a Role for β-Catenin in the Establishment of a Bipolar Mitotic Spindle

The Journal of biological chemistry, 2004-03, Vol.279 (12), p.10829-10832

2004

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Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

Biochemical journal, 1997-02, Vol.321 ( Pt 3) (3), p.561-571

1997

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Structure of mammalian protein geranylgeranyltransferase type-I

The EMBO journal, 2003-11, Vol.22 (22), p.5963-5974

2003

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Targeting Ras Signaling through Inhibition of Carboxyl Methylation: An Unexpected Property of Methotrexate

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (11), p.6529-6534

2003

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A Novel Protein Geranylgeranyltransferase-I Inhibitor with High Potency, Selectivity, and Cellular Activity

The Journal of biological chemistry, 2006-05, Vol.281 (18), p.12445-12450

2006

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Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development

Cancer cell, 2005-04, Vol.7 (4), p.313-324

2005

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Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution

Science (American Association for the Advancement of Science), 1997-03, Vol.275 (5307), p.1800-1804

1997

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Androgen receptor activation by G(s) signaling in prostate cancer cells

The Journal of biological chemistry, 2005-03, Vol.280 (12), p.11583-11589

2005

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Lipid modifications of G proteins

Current opinion in cell biology, 1994-04, Vol.6 (2), p.219-225

Casey, Patrick J.

1994

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Absence of the CAAX Endoprotease Rce1: Effects on Cell Growth and Transformation

Molecular and Cellular Biology, 2002-01, Vol.22 (1), p.171-181

2002

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Cocrystal Structure of Protein Farnesyltransferase Complexed with a Farnesyl Diphosphate Substrate

Biochemistry (Easton), 1998-07, Vol.37 (27), p.9612-9618

1998

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Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice

The Journal of biological chemistry, 2001-02, Vol.276 (8), p.5841-5845

2001

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Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells

The Journal of biological chemistry, 2000-06, Vol.275 (23), p.17605-17610

2000

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High Affinity for Farnesyltransferase and Alternative Prenylation Contribute Individually to K-Ras4B Resistance to Farnesyltransferase Inhibitors

The Journal of biological chemistry, 2003-10, Vol.278 (43), p.41718-41727

2003

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Opinion: Post-prenylation-processing enzymes as new targets in oncogenesis

Biochemistry of protein prenylation

Crystallographic Analysis of CaaX Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity

Protein Lipidation in Cell Signaling

Rap1 GTPase Inhibits Leukocyte Transmigration by Promoting Endothelial Barrier Function

Protein Prenylation: Molecular Mechanisms and Functional Consequences

Protein Prenyltransferases (∗)

Reaction path of protein farnesyltransferase at atomic resolution

A Small-Molecule Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase with Antitumor Activity in Cancer Cells

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Involvement of a Mitochondrial Phosphatase in the Regulation of ATP Production and Insulin Secretion in Pancreatic β Cells

Identification of a Role for β-Catenin in the Establishment of a Bipolar Mitotic Spindle

Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

Structure of mammalian protein geranylgeranyltransferase type-I

Targeting Ras Signaling through Inhibition of Carboxyl Methylation: An Unexpected Property of Methotrexate

A Novel Protein Geranylgeranyltransferase-I Inhibitor with High Potency, Selectivity, and Cellular Activity

Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development

Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution

Androgen receptor activation by G(s) signaling in prostate cancer cells

Lipid modifications of G proteins

Absence of the CAAX Endoprotease Rce1: Effects on Cell Growth and Transformation

Cocrystal Structure of Protein Farnesyltransferase Complexed with a Farnesyl Diphosphate Substrate

Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice

Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells

High Affinity for Farnesyltransferase and Alternative Prenylation Contribute Individually to K-Ras4B Resistance to Farnesyltransferase Inhibitors

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