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Targeting cell cycle regulation in cancer therapy

Pharmacology & therapeutics (Oxford), 2013-05, Vol.138 (2), p.255-271

2013

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AI delivers Michaelis constants as fuel for genome-scale metabolic models

PLoS biology, 2021-10, Vol.19 (10), p.e3001415-e3001415

2021

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Oncogenic regulation of tumor metabolic reprogramming

Oncotarget, 2016-09, Vol.7 (38), p.62726-62753

2016

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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

Nature (London), 2013-06, Vol.498 (7452), p.109-112

2013

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Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

Nature communications, 2022-04, Vol.13 (1), p.2013-2013, Article 2013

2022

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Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative)

Clinical chemistry (Baltimore, Md.), 2018-08, Vol.64 (8), p.1158-1182

2018

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Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

The Journal of immunology (1950), 2010-07, Vol.185 (1), p.605-614

2010

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Metabolomics enables precision medicine: “A White Paper, Community Perspective”

Metabolomics, 2016-09, Vol.12 (9), Article 149

2016

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Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

Cell metabolism, 2014-01, Vol.19 (1), p.37-48

2014

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The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

Nature communications, 2022-03, Vol.13 (1), p.1105-1105, Article 1105

2022

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Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction

eLife, 2023-11, Vol.12

2023

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Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment-Progresses in Their Use in Combined Cancer Therapy

Molecules (Basel, Switzerland), 2024-01, Vol.29 (2), p.331

2024

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Targeting the Metabolic Adaptation of Metastatic Cancer

Cancers, 2021-04, Vol.13 (7), p.1641

2021

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Protein network analyses of pulmonary endothelial cells in chronic thromboembolic pulmonary hypertension

Scientific reports, 2021-03, Vol.11 (1), p.5583-5583, Article 5583

2021

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Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain

PLoS computational biology, 2011-03, Vol.7 (3), p.e1001115-e1001115

2011

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Unveiling a key role of oxaloacetate-glutamate interaction in regulation of respiration and ROS generation in nonsynaptic brain mitochondria using a kinetic model

PloS one, 2021-08, Vol.16 (8), p.e0255164

2021

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Model-driven discovery of long-chain fatty acid metabolic reprogramming in heterogeneous prostate cancer cells

PLoS computational biology, 2018-01, Vol.14 (1), p.e1005914-e1005914

2018

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TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression

International journal of molecular sciences, 2022-03, Vol.23 (7), p.3574

2022

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Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells

PloS one, 2016-01, Vol.11 (1), p.e0146178-e0146178

2016

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Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives

Molecules (Basel, Switzerland), 2019-02, Vol.24 (4), p.766

2019

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Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12751

2023

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Genome Scale Modeling to Study the Metabolic Competition between Cells in the Tumor Microenvironment

Cancers, 2021-09, Vol.13 (18), p.4609

2021

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Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer

BMC genomics, 2019-08, Vol.20 (1), p.652-12, Article 652

2019

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Effect of crowding by Dextrans in enzymatic reactions

Biophysical chemistry, 2014-01, Vol.185, p.8-13

2014

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Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation

PloS one, 2011-09, Vol.6 (9), p.e25323-e25323

2011

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Targeting cell cycle regulation in cancer therapy

AI delivers Michaelis constants as fuel for genome-scale metabolic models

Oncogenic regulation of tumor metabolic reprogramming

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative)

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

Metabolomics enables precision medicine: “A White Paper, Community Perspective”

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction

Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment-Progresses in Their Use in Combined Cancer Therapy

Targeting the Metabolic Adaptation of Metastatic Cancer

Protein network analyses of pulmonary endothelial cells in chronic thromboembolic pulmonary hypertension

Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain

Unveiling a key role of oxaloacetate-glutamate interaction in regulation of respiration and ROS generation in nonsynaptic brain mitochondria using a kinetic model

Model-driven discovery of long-chain fatty acid metabolic reprogramming in heterogeneous prostate cancer cells

TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression

Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells

Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives

Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women

Genome Scale Modeling to Study the Metabolic Competition between Cells in the Tumor Microenvironment

Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer

Effect of crowding by Dextrans in enzymatic reactions

Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation

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