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Pharmacology and Rationale for Seralutinib in the Treatment of Pulmonary Arterial Hypertension

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12653

2023

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Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Cell reports (Cambridge), 2016-12, Vol.17 (12), p.3206-3218

2016

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Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension

The European respiratory journal, 2022-12, Vol.60 (6), p.2102356

2022

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Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists

Nature chemical biology, 2015-02, Vol.11 (2), p.141

2015

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Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists

Nature chemical biology, 2015-01, Vol.11 (2), p.141-147

2015

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In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (14), p.3888-3898

2018

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

Cancer cell, 2023-06, Vol.41 (6), p.1073-1090.e12

2023

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Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ) Agonist for Use in Treating Cancer

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13410-13428

2021

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Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

The Journal of pharmacology and experimental therapeutics, 2008-02, Vol.324 (2), p.497-506

2008

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Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

Oncoimmunology, 2016-12, Vol.5 (12), p.e1254854-e1254854

2016

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PD‐1:PD‐L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL‐2

European journal of immunology, 2002-03, Vol.32 (3), p.634-643

2002

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Nature immunology, 2001-03, Vol.2 (3), p.261-268

2001

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PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis

Journal of neuroimmunology, 2007-01, Vol.182 (1), p.124-134

2007

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IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation: A Mediator of the Transition from Innate to Adaptive Immunity

Immunity (Cambridge, Mass.), 2002-04, Vol.16 (4), p.559-569

2002

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RORγ Agonists Enhance the Sustained Antitumor Activity through Intrinsic Tc17 Cytotoxicity and Tc1 Recruitment

Cancer immunology research, 2019-07, Vol.7 (7), p.1054-1063

2019

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The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease

Cellular immunology, 2012, Vol.272 (2), p.200-213

2012

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Type 1 and Type 2: a fundamental dichotomy for all T-cell subsets

Current opinion in immunology, 1996-06, Vol.8 (3), p.336-342

1996

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In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines

The Journal of immunology (1950), 1998-07, Vol.161 (1), p.97-105

1998

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Therapeutic opportunities in the B7/CD28 family of ligands and receptors

Current opinion in pharmacology, 2005-08, Vol.5 (4), p.424-430

2005

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Single cell analyses of cytokine production

Current opinion in immunology, 1997-04, Vol.9 (2), p.177-182

1997

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Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation

Immunologic research, 2003-01, Vol.28 (1), p.49-59

2003

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Multiple GTP-Binding Proteins Participate in Clathrin-Coated Vesicle-Mediated Endocytosis

The Journal of cell biology, 1993-01, Vol.120 (1), p.37-45

1993

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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

FEBS letters, 2004-09, Vol.574 (1), p.37-41

2004

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Preliminary clinical and biologic results of GB1275, a first-in-class oral CD11b modulator, alone and with pembrolizumab, in advanced solid tumors (KEYNOTE A36)

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.2505-2505

2021

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A phase I/II study of GB1275, a first-in-class oral CD11b modulator, alone, and combined with pembrolizumab in specified advanced solid tumors or with chemotherapy in metastatic pancreatic cancer (KEYNOTE-A36)

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.3085-3085

2020

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Pharmacology and Rationale for Seralutinib in the Treatment of Pulmonary Arterial Hypertension

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension

Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists

Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists

In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo

Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ) Agonist for Use in Treating Cancer

Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

PD‐1:PD‐L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL‐2

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis

IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation: A Mediator of the Transition from Innate to Adaptive Immunity

RORγ Agonists Enhance the Sustained Antitumor Activity through Intrinsic Tc17 Cytotoxicity and Tc1 Recruitment

The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease

Type 1 and Type 2: a fundamental dichotomy for all T-cell subsets

In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines

Therapeutic opportunities in the B7/CD28 family of ligands and receptors

Single cell analyses of cytokine production

Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation

Multiple GTP-Binding Proteins Participate in Clathrin-Coated Vesicle-Mediated Endocytosis

PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

Preliminary clinical and biologic results of GB1275, a first-in-class oral CD11b modulator, alone and with pembrolizumab, in advanced solid tumors (KEYNOTE A36)

A phase I/II study of GB1275, a first-in-class oral CD11b modulator, alone, and combined with pembrolizumab in specified advanced solid tumors or with chemotherapy in metastatic pancreatic cancer (KEYNOTE-A36)

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