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An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

Nature communications, 2021-03, Vol.12 (1), p.1881-20, Article 1881

2021

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Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Blood, 2021-10, Vol.138 (16), p.1441-1455

2021

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Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN

Cancer research (Chicago, Ill.), 2018-06, Vol.78 (12), p.3122-3134

2018

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Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory

Cell reports (Cambridge), 2022-10, Vol.41 (1), p.111455-111455, Article 111455

2022

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Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma

International journal of molecular sciences, 2023-11, Vol.24 (21), p.15571

2023

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Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes

PloS one, 2014-04, Vol.9 (4), p.e95253-e95253

2014

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MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

Cancers, 2021-09, Vol.13 (19), p.4783

2021

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MYCN-targeting miRNAs are predominantly downregulated during MYCN‑driven neuroblastoma tumor formation

Oncotarget, 2015-03, Vol.6 (7), p.5204-5216

2015

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Increase in DNA Damage by MYCN Knockdown Through Regulating Nucleosome Organization and Chromatin State in Neuroblastoma

Frontiers in genetics, 2019-07, Vol.10, p.684-684

2019

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The prenatal origins of cancer

Nature reviews. Cancer, 2014-04, Vol.14 (4), p.277

2014

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SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4

PloS one, 2012-11, Vol.7 (11), p.e50637

2012

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MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression

Oncogene, 2024-01, Vol.43 (5), p.363-377

2024

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LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis

Clinical cancer research, 2018-11, Vol.24 (22), p.5772-5783

2018

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Correction: SUMOylation Regulates the Transcriptional Repression Activity of FOG-2 and Its Association with GATA-4

PloS one, 2013-05, Vol.8 (5)

2013

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Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN‐amplified neuroblastoma

International journal of cancer, 2020-10, Vol.147 (7), p.1928-1938

2020

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Mesoderm-derived PDGFRA + cells regulate the emergence of hematopoietic stem cells in the dorsal aorta

Nature cell biology, 2022-08, Vol.24 (8), p.1211

2022

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Withaferin A activates TRIM16 for its anti-cancer activity in melanoma

Scientific reports, 2020-11, Vol.10 (1), p.19724, Article 19724

2020

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Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Clinical cancer research, 2021-08, Vol.27 (15), p.4338-4352

2021

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The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis

Nature communications, 2024-07, Vol.15 (1), p.5585-21, Article 5585

2024

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Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma

International journal of cancer, 2023-04, Vol.152 (7), p.1399-1413

2023

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A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

Oncogene, 2021-04, Vol.40 (13), p.2367-2381

2021

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Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Cancer research (Chicago, Ill.), 2019-11, Vol.79 (21), p.5652-5667

2019

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An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment

Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory

Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma

Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

MYCN-targeting miRNAs are predominantly downregulated during MYCN‑driven neuroblastoma tumor formation

Increase in DNA Damage by MYCN Knockdown Through Regulating Nucleosome Organization and Chromatin State in Neuroblastoma

The prenatal origins of cancer

SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4

MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression

LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

Correction: SUMOylation Regulates the Transcriptional Repression Activity of FOG-2 and Its Association with GATA-4

Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN‐amplified neuroblastoma

Mesoderm-derived PDGFRA + cells regulate the emergence of hematopoietic stem cells in the dorsal aorta

Withaferin A activates TRIM16 for its anti-cancer activity in melanoma

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis

Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma

A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

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