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Structure-based discovery of novel P-glycoprotein inhibitors targeting the nucleotide binding domains

Scientific reports, 2023-12, Vol.13 (1), p.21217-21217, Article 21217

2023

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Recent Advances in Photothermal Therapies Against Cancer and the Role of Membrane Transporter Modulators on the Efficacy of This Approach

Technology in Cancer Research & Treatment, 2023-01, Vol.22, p.15330338231168016-15330338231168016

2023

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Glutamate Efflux at the Blood–Brain Barrier: Cellular Mechanisms and Potential Clinical Relevance

Archives of medical research, 2014-11, Vol.45 (8), p.639-645

2014

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Exploring Amino Acid Transporters as Therapeutic Targets for Cancer: An Examination of Inhibitor Structures, Selectivity Issues, and Discovery Approaches

Pharmaceutics, 2024-01, Vol.16 (2), p.197

2024

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Investigations of potential non-amino acid SNAT2 inhibitors

Frontiers in pharmacology, 2024-01, Vol.14, p.1302445-1302445

2024

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P-glycoprotein-mediated transport in a mucus-supplemented Caco-2 cell model in the presence of different surfactants

International journal of pharmaceutics, 2022-08, Vol.624, p.121885-121885, Article 121885

2022

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Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

Pharmaceutics, 2023-01, Vol.15 (1), p.283

2023

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An Electrically Tight In Vitro Blood–Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

The AAPS journal, 2014-09, Vol.16 (5), p.1046-1055

2014

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Phe-Gly Dipeptidomimetics Designed for the Di-/Tripeptide Transporters PEPT1 and PEPT2: Synthesis and Biological Investigations

Journal of medicinal chemistry, 2004-02, Vol.47 (4), p.1060-1069

2004

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Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition

International journal of pharmaceutics: X, 2021-12, Vol.3, p.100089-100089, Article 100089

2021

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Oral and intravenous pharmacokinetics of taurine in sprague‐dawley rats: the influence of dose and the possible involvement of the proton‐coupled amino acid transporter, PAT1, in oral taurine absorption

Physiological reports, 2017-10, Vol.5 (19), p.e13467-n/a

2017

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Calu-3 cells grown under AIC and LCC conditions: Implications for dipeptide uptake and transepithelial transport of substances

European journal of pharmaceutics and biopharmaceutics, 2011-05, Vol.78 (1), p.19-26

2011

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In vivo and In vitro Evaluations of Intestinal Gabapentin Absorption: Effect of Dose and Inhibitors on Carrier-Mediated Transport

Pharmaceutical research, 2015-03, Vol.32 (3), p.898-909

2015

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Ibuprofen is a non‐competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen

British journal of pharmacology, 2010-12, Vol.161 (8), p.1793-1805

2010

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Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/Astrocyte Blood–Brain Barrier Model by Increasing Media Buffer Capacity During Growth

The AAPS journal, 2010-12, Vol.12 (4), p.759-770

2010

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Nfat5 is involved in the hyperosmotic regulation of Tmem184b: a putative modulator of ibuprofen transport in renal MDCK I cells

FEBS open bio, 2019-06, Vol.9 (6), p.1071-1081

2019

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Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions

The Journal of pharmacology and experimental therapeutics, 2004-12, Vol.311 (3), p.1088

2004

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Molecular Networks and Macromolecular Molar Mass Distributions for Preliminary Characterization of Danish Craft Beers

Beverages (Basel), 2022-06, Vol.8 (2), p.35

2022

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Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Pharmaceutics, 2020-04, Vol.12 (4), p.390

2020

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5-Hydroxy- l-tryptophan alters gaboxadol pharmacokinetics in rats: Involvement of PAT1 and rOat1 in gaboxadol absorption and elimination

European journal of pharmaceutical sciences, 2010-01, Vol.39 (1), p.68-75

2010

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The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (15), p.4597-4601

2011

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Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

European Journal of Pharmaceutical Sciences, 2004, Vol.21 (1), p.3-16

2004

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Mechanism behind Polysorbates’ Inhibitory Effect on P‑Glycoprotein

Molecular pharmaceutics, 2022-07, Vol.19 (7), p.2248-2253

2022

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Genetic variants of the human dipeptide transporter PEPT1

The Journal of pharmacology and experimental therapeutics, 2006-02, Vol.316 (2), p.636

2006

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Digestion of surfactants does not affect their ability to inhibit P-gp-mediated transport in vitro

International journal of pharmaceutics, 2024-05, Vol.656, p.124120-124120, Article 124120

2024

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Structure-based discovery of novel P-glycoprotein inhibitors targeting the nucleotide binding domains

Recent Advances in Photothermal Therapies Against Cancer and the Role of Membrane Transporter Modulators on the Efficacy of This Approach

Glutamate Efflux at the Blood–Brain Barrier: Cellular Mechanisms and Potential Clinical Relevance

Exploring Amino Acid Transporters as Therapeutic Targets for Cancer: An Examination of Inhibitor Structures, Selectivity Issues, and Discovery Approaches

Investigations of potential non-amino acid SNAT2 inhibitors

P-glycoprotein-mediated transport in a mucus-supplemented Caco-2 cell model in the presence of different surfactants

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

An Electrically Tight In Vitro Blood–Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

Phe-Gly Dipeptidomimetics Designed for the Di-/Tripeptide Transporters PEPT1 and PEPT2: Synthesis and Biological Investigations

Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition

Oral and intravenous pharmacokinetics of taurine in sprague‐dawley rats: the influence of dose and the possible involvement of the proton‐coupled amino acid transporter, PAT1, in oral taurine absorption

Calu-3 cells grown under AIC and LCC conditions: Implications for dipeptide uptake and transepithelial transport of substances

In vivo and In vitro Evaluations of Intestinal Gabapentin Absorption: Effect of Dose and Inhibitors on Carrier-Mediated Transport

Ibuprofen is a non‐competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen

Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/Astrocyte Blood–Brain Barrier Model by Increasing Media Buffer Capacity During Growth

Nfat5 is involved in the hyperosmotic regulation of Tmem184b: a putative modulator of ibuprofen transport in renal MDCK I cells

Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions

Molecular Networks and Macromolecular Molar Mass Distributions for Preliminary Characterization of Danish Craft Beers

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

5-Hydroxy- l-tryptophan alters gaboxadol pharmacokinetics in rats: Involvement of PAT1 and rOat1 in gaboxadol absorption and elimination

The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1

Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

Mechanism behind Polysorbates’ Inhibitory Effect on P‑Glycoprotein

Genetic variants of the human dipeptide transporter PEPT1

Digestion of surfactants does not affect their ability to inhibit P-gp-mediated transport in vitro

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