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Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.710-721

2017

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LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice

The Journal of pharmacology and experimental therapeutics, 2017-07, Vol.362 (1), p.85

2017

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Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa Using DNA-Encoded Small Molecule Library Screening

ACS chemical biology, 2020-02, Vol.15 (2), p.446-456

2020

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Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (6), p.1525-1528

2016

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Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8650-8662

2010

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4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (4), p.1184-1187

2016

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Synthesis and structure–Activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-Molecule antagonists for interleukin-8 receptor

Bioorganic & medicinal chemistry, 2003-08, Vol.11 (17), p.3777-3790

2003

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Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1)

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3849-3862

1996

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Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6784-6787

2009

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5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6780-6783

2009

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Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of ( E )-1-(4-((1 R ,2 S ,3 R )-1,2,3,4-Tetrahydroxybutyl)-1 H -imidazol-2-yl)ethanone Oxime (LX2931) and (1 R ,2 S ,3 R )-1-(2-(Isoxazol-3-yl)-1 H -imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8650-8662

2010

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Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures1

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3849-3862

1996

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Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydride

Tetrahedron letters, 1990, Vol.31 (39), p.5595-5598

1990

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Sulfonopeptide inhibitors of leukocyte adhesion

Bioorganic & medicinal chemistry letters, 1997-03, Vol.7 (6), p.711-714

1997

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Studies on morpholinosphingolipids: Potent inhibitors of glucosylceramide synthase

Tetrahedron letters, 1994-04, Vol.35 (17), p.2659-2662

1994

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CCR1 Antagonists

Annual Reports in Medicinal Chemistry, 2004, Vol.39, p.149-158

2004

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Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures 1

Journal of organic chemistry, 1996-01, Vol.61 (11), p.3849-3862

1996

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Arthroscopy of the shoulder: Technique and normal anatomy

The American journal of sports medicine, 1984-01, Vol.12 (1), p.1-7

1984

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The reactions of an o-quinone monoimide with some phenols

Journal of organic chemistry, 1990-06, Vol.55 (13), p.4039-4043

1990

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Curtius rearrangement in the 5-phenyl-1,4-benzodiazepine series. Unprecedented participation by an imine nitrogen

Journal of heterocyclic chemistry, 1990-03, Vol.27 (3), p.631-636

1990

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Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

The Lancet regional health. Europe, 2021-09, Vol.8, p.100186-100186, Article 100186

2021

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Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes

LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice

Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa Using DNA-Encoded Small Molecule Library Screening

Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase

Synthesis and structure–Activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-Molecule antagonists for interleukin-8 receptor

Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1)

Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders

Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors

5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of ( E )-1-(4-((1 R ,2 S ,3 R )-1,2,3,4-Tetrahydroxybutyl)-1 H -imidazol-2-yl)ethanone Oxime (LX2931) and (1 R ,2 S ,3 R )-1-(2-(Isoxazol-3-yl)-1 H -imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures1

Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydride

Sulfonopeptide inhibitors of leukocyte adhesion

Studies on morpholinosphingolipids: Potent inhibitors of glucosylceramide synthase

CCR1 Antagonists

Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures 1

Arthroscopy of the shoulder: Technique and normal anatomy

The reactions of an o-quinone monoimide with some phenols

Curtius rearrangement in the 5-phenyl-1,4-benzodiazepine series. Unprecedented participation by an imine nitrogen

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

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