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Population Pharmacokinetics of Selumetinib and Its Metabolite N‐desmethyl‐selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low‐Grade Gliomas

CPT: pharmacometrics and systems pharmacology, 2017-05, Vol.6 (5), p.305-314

2017

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Population Pharmacokinetics of Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia (CLL) and Non‐Hodgkin's Lymphoma and Exposure–Response in CLL

CPT: pharmacometrics and systems pharmacology, 2014-10, Vol.3 (10), p.1-11

2014

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SELECT-2: a phase II, double-blind, randomized, placebo-controlled study to assess the efficacy of selumetinib plus docetaxel as a second-line treatment of patients with advanced or metastatic non-small-cell lung cancer

Annals of oncology, 2017-12, Vol.28 (12), p.3028-3036

2017

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Challenges and Opportunities for Quantitative Clinical Pharmacology in Cancer Immunotherapy: Something Old, Something New, Something Borrowed, and Something Blue

CPT: pharmacometrics and systems pharmacology, 2015-09, Vol.4 (9), p.495-497

2015

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Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices

Drug metabolism reviews, 1997-01, Vol.29 (4), p.891-922

1997

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Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

British journal of clinical pharmacology, 1999-06, Vol.47 (6), p.625-635

1999

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Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans

Xenobiotica, 2005-06, Vol.35 (6), p.603-625

2005

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Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam

Drug metabolism and disposition, 1997-08, Vol.25 (8), p.903

1997

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Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial

Journal of clinical oncology, 2021-06, Vol.39 (18), p.1959-1970

2021

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Implications and consequences of enzyme induction on preclinical and clinical drug development

Xenobiotica, 2001-08, Vol.31 (8-9), p.539-556

2001

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Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

Xenobiotica, 2002-11, Vol.32 (11), p.937-947

2002

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Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data

The Journal of pharmacology and experimental therapeutics, 1995-08, Vol.274 (2), p.761

1995

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Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity

Drug metabolism and disposition, 1999-04, Vol.27 (4), p.526

1999

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Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models

Toxicology in vitro, 1997-10, Vol.11 (5), p.473-478

1997

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In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes

Drug metabolism and disposition, 1998-03, Vol.26 (3), p.216

1998

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Rationale for optimal obinutuzumab/GA101 dosing regimen in B-cell non-Hodgkin lymphoma

Haematologica (Roma), 2016-02, Vol.101 (2), p.226-234

2016

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Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance

Xenobiotica, 1995, Vol.25 (9), p.907-916

1995

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The Use of Tissue Slices for Pharmacotoxicology Studies: The Report and Recommendations of ECVAM Workshop 20

Alternatives to laboratory animals, 1996-11, Vol.24 (6), p.893-919

1996

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Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

Pharmaceutical research, 2006-03, Vol.23 (3), p.533-539

2006

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Implications and consequences of enzyme induction on preclinical and clinical drug development: The Drug Metabolism Discussion Group in 2001

Xenobiotica, 2001, Vol.31 (8-9), p.539-556

2001

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Terramycin in Serum and Urine After Ingestion of Terramycin Base

Journal of the American Pharmaceutical Association (Scientific ed.), 1951-11, Vol.40 (11), p.535-536

1951

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Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

Nature Medicine, 2019-12, Vol.25 (12), p.1873-1884

2019

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The European Spallation Source neutrino super-beam conceptual design report

The European physical journal. ST, Special topics, 2022, Vol.231 (21), p.3779-3955

2022

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Optically measured microvascular blood flow contrast of malignant breast tumors

PloS one, 2014-06, Vol.9 (6), p.e99683-e99683

2014

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A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies

Blood, 2012-05, Vol.119 (22), p.5118-5125

2012

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Population Pharmacokinetics of Selumetinib and Its Metabolite N‐desmethyl‐selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low‐Grade Gliomas

Population Pharmacokinetics of Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia (CLL) and Non‐Hodgkin's Lymphoma and Exposure–Response in CLL

SELECT-2: a phase II, double-blind, randomized, placebo-controlled study to assess the efficacy of selumetinib plus docetaxel as a second-line treatment of patients with advanced or metastatic non-small-cell lung cancer

Challenges and Opportunities for Quantitative Clinical Pharmacology in Cancer Immunotherapy: Something Old, Something New, Something Borrowed, and Something Blue

Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam

Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial

Implications and consequences of enzyme induction on preclinical and clinical drug development

Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data

Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity

Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models

In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes

Rationale for optimal obinutuzumab/GA101 dosing regimen in B-cell non-Hodgkin lymphoma

Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance

The Use of Tissue Slices for Pharmacotoxicology Studies: The Report and Recommendations of ECVAM Workshop 20

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

Implications and consequences of enzyme induction on preclinical and clinical drug development: The Drug Metabolism Discussion Group in 2001

Terramycin in Serum and Urine After Ingestion of Terramycin Base

Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

The European Spallation Source neutrino super-beam conceptual design report

Optically measured microvascular blood flow contrast of malignant breast tumors

A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies

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