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A machine learning model trained on a high-throughput antibacterial screen increases the hit rate of drug discovery

PLoS computational biology, 2022-10, Vol.18 (10), p.e1010613-e1010613

2022

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Deep clustering of small molecules at large-scale via variational autoencoder embedding and K-means

BMC bioinformatics, 2022-04, Vol.23 (Suppl 4), p.132-132, Article 132

2022

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Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium

Nature communications, 2023-08, Vol.14 (1), p.4815-4815, Article 4815

2023

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Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci

Journal of antibiotics, 2012-02, Vol.65 (2), p.73-77

2012

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ABT-MPNN: an atom-bond transformer-based message-passing neural network for molecular property prediction

Journal of cheminformatics, 2023-02, Vol.15 (1), p.29-29, Article 29

2023

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The Phenylacetic Acid Catabolic Pathway Regulates Antibiotic and Oxidative Stress Responses in Acinetobacter

mBio, 2022-06, Vol.13 (3), p.e0186321-e0186321

2022

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Identification of putative essential protein domains from high-density transposon insertion sequencing

Scientific reports, 2022-01, Vol.12 (1), p.962-10, Article 962

2022

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Understanding the Pathogenicity of Burkholderia contaminans, an Emerging Pathogen in Cystic Fibrosis

PloS one, 2016-08, Vol.11 (8), p.e0160975-e0160975

2016

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Synthesis and antibiotic activity of novel acylated phloroglucinol compounds against methicillin-resistant Staphylococcus aureus

Journal of antibiotics, 2019-05, Vol.72 (5), p.253-259

2019

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A c-di-GMP-Modulating Protein Regulates Swimming Motility of Burkholderia cenocepacia in Response to Arginine and Glutamate

Frontiers in cellular and infection microbiology, 2018-02, Vol.8, p.56-56

2018

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Characterization of the Poly-β-1,6-N-Acetylglucosamine Polysaccharide Component of Burkholderia Biofilms

Applied and Environmental Microbiology, 2011-12, Vol.77 (23), p.8303-8309

2011

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A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia

PloS one, 2015-06, Vol.10 (6), p.e0128587

2015

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Deep learning-driven prediction of drug mechanism of action from large-scale chemical-genetic interaction profiles

Journal of cheminformatics, 2022-03, Vol.14 (1), p.12-12, Article 12

2022

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The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling

Microbiology spectrum, 2024-02, Vol.12 (2), p.e0320123-e0320123

2024

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New Auranofin Analogs with Antibacterial Properties against Burkholderia Clinical Isolates

Antibiotics (Basel), 2021-11, Vol.10 (12), p.1443

2021

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A Functional Phenylacetic Acid Catabolic Pathway Is Required for Full Pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans Host Model

Journal of Bacteriology, 2008-11, Vol.190 (21), p.7209-7218

2008

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Gradients in gene essentiality reshape antibacterial research

FEMS microbiology reviews, 2022-05, Vol.46 (3), p.1

2022

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The Effect of 2-Thiocyanatopyridine Derivative 11026103 on Burkholderia Cenocepacia : Resistance Mechanisms and Systemic Impact

Antibiotics (Basel), 2019-09, Vol.8 (4), p.159

2019

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A Putative Gene Cluster for Aminoarabinose Biosynthesis Is Essential for Burkholderia cenocepacia Viability

Journal of Bacteriology, 2007-05, Vol.189 (9), p.3639-3644

2007

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Cell envelope structural and functional contributions to antibiotic resistance in Burkholderia cenocepacia

Journal of bacteriology, 2024-04, Vol.206 (4), p.e0044123

2024

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Improved Dynamic Range of a Rhamnose-Inducible Promoter for Gene Expression in Burkholderia spp

Applied and environmental microbiology, 2021-08, Vol.87 (18), p.e0064721-e0064721

2021

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Regulation of phenylacetic acid degradation genes of Burkholderia cenocepacia K56-2

BMC microbiology, 2009-10, Vol.9 (1), p.222-222, Article 222

2009

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Essential Two-Component Systems Regulating Cell Envelope Functions: Opportunities for Novel Antibiotic Therapies

The Journal of membrane biology, 2018-02, Vol.251 (1), p.75-89

2018

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A Quorum-Quenching Approach To Investigate the Conservation of Quorum-Sensing-Regulated Functions within the Burkholderia cepacia Complex

Applied and Environmental Microbiology, 2006-02, Vol.72 (2), p.1579-1587

2006

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A CRISPR-Cas-associated transposon system for genome editing in Burkholderia cepacia complex species

Applied and environmental microbiology, 2024-07, Vol.90 (7)

2024

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A machine learning model trained on a high-throughput antibacterial screen increases the hit rate of drug discovery

Deep clustering of small molecules at large-scale via variational autoencoder embedding and K-means

Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium

Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci

ABT-MPNN: an atom-bond transformer-based message-passing neural network for molecular property prediction

The Phenylacetic Acid Catabolic Pathway Regulates Antibiotic and Oxidative Stress Responses in Acinetobacter

Identification of putative essential protein domains from high-density transposon insertion sequencing

Understanding the Pathogenicity of Burkholderia contaminans, an Emerging Pathogen in Cystic Fibrosis

Synthesis and antibiotic activity of novel acylated phloroglucinol compounds against methicillin-resistant Staphylococcus aureus

A c-di-GMP-Modulating Protein Regulates Swimming Motility of Burkholderia cenocepacia in Response to Arginine and Glutamate

Characterization of the Poly-β-1,6-N-Acetylglucosamine Polysaccharide Component of Burkholderia Biofilms

A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia

Deep learning-driven prediction of drug mechanism of action from large-scale chemical-genetic interaction profiles

The mechanism of action of auranofin analogs in B. cenocepacia revealed by chemogenomic profiling

New Auranofin Analogs with Antibacterial Properties against Burkholderia Clinical Isolates

A Functional Phenylacetic Acid Catabolic Pathway Is Required for Full Pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans Host Model

Gradients in gene essentiality reshape antibacterial research

The Effect of 2-Thiocyanatopyridine Derivative 11026103 on Burkholderia Cenocepacia : Resistance Mechanisms and Systemic Impact

A Putative Gene Cluster for Aminoarabinose Biosynthesis Is Essential for Burkholderia cenocepacia Viability

Cell envelope structural and functional contributions to antibiotic resistance in Burkholderia cenocepacia

Improved Dynamic Range of a Rhamnose-Inducible Promoter for Gene Expression in Burkholderia spp

Regulation of phenylacetic acid degradation genes of Burkholderia cenocepacia K56-2

Essential Two-Component Systems Regulating Cell Envelope Functions: Opportunities for Novel Antibiotic Therapies

A Quorum-Quenching Approach To Investigate the Conservation of Quorum-Sensing-Regulated Functions within the Burkholderia cepacia Complex

A CRISPR-Cas-associated transposon system for genome editing in Burkholderia cepacia complex species

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