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Clinical research and drug regulation in the challenging times of individualized therapies: A pivotal role of clinical pharmacology

Pharmacological research, 2024-01, Vol.199, p.107045-107045, Article 107045

2024

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Outcomes and Costs of Poisoned Patients Admitted to an Adult Emergency Department of a Spanish Tertiary Hospital: Evaluation through a Toxicovigilance Program

PloS one, 2016-04, Vol.11 (4), p.e0152876

2016

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An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in Spanish patients with thromboembolic disease

PloS one, 2012-07, Vol.7 (7), p.e41360

2012

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Severe Hyponatremia Is Often Drug Induced: 10‐Year Results of a Prospective Pharmacovigilance Program

Clinical pharmacology and therapeutics, 2019-12, Vol.106 (6), p.1362-1379

2019

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Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR

Nature biotechnology, 2022-11, Vol.40 (11), p.1680-1689

2022

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Implementing pharmacogenetics in clinical trials: considerations about current methodological, ethical, and regulatory challenges

Expert review of clinical pharmacology, 2024, Vol.17 (1), p.1-10

2024

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A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial

Trials, 2020-06, Vol.21 (1), p.466-4, Article 466

2020

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Comparative effectiveness medicines research cannot assess efficacy

Journal of clinical epidemiology, 2017-12, Vol.92, p.129-129

2017

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Prediction models for voriconazole pharmacokinetics based on pharmacogenetics: AN exploratory study in a Spanish population

International journal of antimicrobial agents, 2019-10, Vol.54 (4), p.463-470

2019

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A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population

PloS one, 2016-03, Vol.11 (3), p.e0150456-e0150456

2016

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Evaluation of factors associated with recruitment rates in early phase clinical trials based on the European Clinical Trials Register data

Clinical and translational science, 2023-12, Vol.16 (12), p.2654-2664

2023

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Who is willing to participate in low-risk pragmatic clinical trials without consent?

European journal of clinical pharmacology, 2017-12, Vol.73 (12), p.1557-1563

2017

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Advancing pharmacogenetic testing in a tertiary hospital: a retrospective analysis after 10 years of activity

Frontiers in pharmacology, 2023-10, Vol.14, p.1292416-1292416

2023

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Incidence of Suspected Serious Adverse Drug Reactions in Corona Virus Disease-19 Patients Detected by a Pharmacovigilance Program by Laboratory Signals in a Tertiary Hospital in Spain: Cautionary Data

Frontiers in pharmacology, 2020-12, Vol.11, p.602841

2020

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Strategy to effectively and efficiently implement voriconazole pharmacogenetics in clinical practice

Pharmacogenomics, 2020-07, Vol.21 (10), p.647-649

2020

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Influence of Genetic Polymorphisms on the Response to Tramadol, Ibuprofen, and the Combination in Patients With Moderate to Severe Pain After Dental Surgery

Clinical therapeutics, 2021-05, Vol.43 (5), p.e86-e102

2021

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Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units

Clinical and translational science, 2023-12, Vol.16 (12), p.2421-2428

2023

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ALDRESS: A Retrospective Pilot Study to Develop a Pharmacological Causality Algorithm for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

Journal of clinical medicine, 2024-05, Vol.13 (9), p.2622

2024

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Patients' beliefs regarding informed consent for low-risk pragmatic trials

BMC medical research methodology, 2017-09, Vol.17 (1), p.145-145, Article 145

2017

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Limited sampling strategies for once daily tacrolimus exposure monitoring

European journal of clinical pharmacology, 2016-06, Vol.72 (6), p.773-774

Carcas-Sansuán, Antonio J.

2016

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Clinical research and drug regulation in the challenging times of individualized therapies: A pivotal role of clinical pharmacology

Outcomes and Costs of Poisoned Patients Admitted to an Adult Emergency Department of a Spanish Tertiary Hospital: Evaluation through a Toxicovigilance Program

An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in Spanish patients with thromboembolic disease

Severe Hyponatremia Is Often Drug Induced: 10‐Year Results of a Prospective Pharmacovigilance Program

Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR

Implementing pharmacogenetics in clinical trials: considerations about current methodological, ethical, and regulatory challenges

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial

Acute respiratory distress syndrome after convalescent plasma use: treatment of a patient with Ebola virus disease contracted in Madrid, Spain

A Case-Control of Patients with COVID-19 to Explore the Association of Previous Hospitalisation Use of Medication on the Mortality of COVID-19 Disease: A Propensity Score Matching Analysis

Comparative effectiveness medicines research cannot assess efficacy

Prediction models for voriconazole pharmacokinetics based on pharmacogenetics: AN exploratory study in a Spanish population

A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population

Evaluation of factors associated with recruitment rates in early phase clinical trials based on the European Clinical Trials Register data

Tenofovir Disoproxil Fumarate/Emtricitabine and Baricitinib for Patients at High Risk of Severe Coronavirus Disease 2019: The PANCOVID Randomized Clinical Trial

Who is willing to participate in low-risk pragmatic clinical trials without consent?

Advancing pharmacogenetic testing in a tertiary hospital: a retrospective analysis after 10 years of activity

Immunogenicity and reactogenicity of a first booster with BNT162b2 or full-dose mRNA-1273: A randomised VACCELERATE trial in adults ≥75 years (EU-COVAT-1)

Incidence of Suspected Serious Adverse Drug Reactions in Corona Virus Disease-19 Patients Detected by a Pharmacovigilance Program by Laboratory Signals in a Tertiary Hospital in Spain: Cautionary Data

Strategy to effectively and efficiently implement voriconazole pharmacogenetics in clinical practice

Influence of Genetic Polymorphisms on the Response to Tramadol, Ibuprofen, and the Combination in Patients With Moderate to Severe Pain After Dental Surgery

Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units

ALDRESS: A Retrospective Pilot Study to Develop a Pharmacological Causality Algorithm for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

Patients' beliefs regarding informed consent for low-risk pragmatic trials

Limited sampling strategies for once daily tacrolimus exposure monitoring

Significant HLA class I type associations with aromatic antiepileptic drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population

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