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Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors

Journal of medicinal chemistry, 2012-02, Vol.55 (4), p.1465-1477

2012

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Dual-acting histone deacetylase-topoisomerase I inhibitors

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3283-3287

2013

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Interaction of anthracyclines with iron responsive element mRNAs

Nucleic acids research, 2008-12, Vol.36 (21), p.6825

2008

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Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity

European journal of medicinal chemistry, 2013, Vol.70, p.273-279

2013

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Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling

Oncotarget, 2017-09, Vol.8 (41), p.69264-69280

2017

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Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

Oncotarget, 2015-09, Vol.6 (29), p.27403-27415

2015

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Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.326-326

2016

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Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2016-01, Vol.12 (5), p.472

2016

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Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors

Scientia pharmaceutica, 2015-09, Vol.84 (3), p.428-446

2015

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Novel Quinazolin-4(3H)-one/Schiff Base Hybrids as Antiproliferative and Phosphodiesterase 4 Inhibitors: Design, Synthesis, and Docking Studies

Archiv der Pharmazie (Weinheim), 2014-09, Vol.347 (9), p.650-657

2014

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Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors

Archiv der Pharmazie (Weinheim), 2016-02, Vol.349 (2), p.104-111

2016

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Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6588-6590

2009

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Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome

ACS chemical biology, 2014-11, Vol.9 (11), p.2621-2631

2014

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Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

Oncogene, 2015-03, Vol.34 (12), p.1499-1509

2015

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Upregulation of cellular protective mechanisms against oxidative damage via pharmacological intervention

The FASEB journal, 2019-04, Vol.33 (S1), p.651.1-651.1

2019

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Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4972-4972

2017

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Abstract B23: DC070-547, a novel Ras inhibitor potently and selectivity inhibits colon tumor growth in vitro and in vivo

Cancer research (Chicago, Ill.), 2017-02, Vol.77 (3_Supplement), p.B23-B23

2017

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Abstract 4372: Phosphodiesterase 10A inhibition suppresses lung tumor cell growth by activating PKG to inhibit ras and Wnt signaling

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4372-4372

2015

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Abstract 701: A novel class of Ras selective inhibitors

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.701-701

2015

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Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1238-1238

2016

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Abstract 1140: Characterization of a novel PDE10 inhibitor in lung tumor cells and an orthotopic mouse model of lung cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1140-1140

2017

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Abstract 950: Antitumor activity of a novel phosphodiesterase 10 inhibitor in an orthotopic mouse model of lung cancer

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.950-950

2015

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PDE10 inhibitors suppress lung tumor growth in mice

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.e22187-e22187

2014

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Abstract A140: Novel drug development candidate potently and selectively inhibits growth of tumor cells harboring activated Ras

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.A140-A140

2015

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Abstract B39: A novel series of substituted indene derivatives that potently and selectively inhibit growth of tumor cells harboring mutant Ras

Molecular cancer research, 2014-12, Vol.12 (12_Supplement), p.B39-B39

2014

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Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors

Dual-acting histone deacetylase-topoisomerase I inhibitors

Interaction of anthracyclines with iron responsive element mRNAs

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity

Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class

Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors

Novel Quinazolin-4(3H)-one/Schiff Base Hybrids as Antiproliferative and Phosphodiesterase 4 Inhibitors: Design, Synthesis, and Docking Studies

Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors

Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide

Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

Upregulation of cellular protective mechanisms against oxidative damage via pharmacological intervention

Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells

Abstract B23: DC070-547, a novel Ras inhibitor potently and selectivity inhibits colon tumor growth in vitro and in vivo

Abstract 4372: Phosphodiesterase 10A inhibition suppresses lung tumor cell growth by activating PKG to inhibit ras and Wnt signaling

Abstract 701: A novel class of Ras selective inhibitors

Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding

Abstract 1140: Characterization of a novel PDE10 inhibitor in lung tumor cells and an orthotopic mouse model of lung cancer

Abstract 950: Antitumor activity of a novel phosphodiesterase 10 inhibitor in an orthotopic mouse model of lung cancer

PDE10 inhibitors suppress lung tumor growth in mice

Abstract A140: Novel drug development candidate potently and selectively inhibits growth of tumor cells harboring activated Ras

Abstract B39: A novel series of substituted indene derivatives that potently and selectively inhibit growth of tumor cells harboring mutant Ras

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