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From molecules to visuals: Empowering drug discovery and development with mass spectrometry imaging

Journal of mass spectrometry., 2024-05, Vol.59 (5), p.e5029-n/a

2024

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Applying Automation and High-Throughput MALDI Mass Spectrometry for Peptide Metabolic Stability Screening

Journal of the American Society for Mass Spectrometry, 2023-06, Vol.34 (6), p.1196-1200

2023

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Optimization of dropletProbe-Mass Spectrometry for Whole-Body Tissue Distribution Analysis of Drug-Like Molecules

Journal of the American Society for Mass Spectrometry, 2020-12, Vol.31 (12), p.2558-2562

2020

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Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II

Analytica chimica acta, 2020-08, Vol.1125, p.279-287

2020

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Rapid and Definitive Identification of Cyclic Peptide Soft Spots by Isotope-Labeled Reductive Dimethylation and Mass Spectrometry Fragmentation

Analytical chemistry (Washington), 2024-05, Vol.96 (19), p.7756-7762

2024

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Development and Application of DropletProbe Mass Spectrometry for Examining Biodistribution of Therapeutics

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2437, p.171

2022

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Mass spectrometry imaging of diclofenac and its metabolites in tissues using nanospray desorption electrospray ionization

Analytica chimica acta, 2022-11, Vol.1233, p.340490-340490, Article 340490

2022

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Metabolite Identification of Therapeutic Peptides and Proteins by Top-down Differential Mass Spectrometry and Metabolite Database Matching

Analytical chemistry (Washington), 2020-06, Vol.92 (12), p.8298-8305

2020

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Top-Down Interrogation of Chemically Modified Oligonucleotides by Negative Electron Transfer and Collision Induced Dissociation

Analytical chemistry (Washington), 2013-05, Vol.85 (9), p.4713-4720

2013

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Differentiation of Deprotonated Acyl‑, N‑, and O‑Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation

Analytical chemistry (Washington), 2019-09, Vol.91 (17), p.11388-11396

2019

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Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

Journal of the American Chemical Society, 2016-02, Vol.138 (4), p.1430-1445

2016

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5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates

Chembiochem : a European journal of chemical biology, 2016-06, Vol.17 (11), p.985-989

2016

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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (13), p.2905-2913

2019

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Small-Molecule Inhibition of TNF-α

Science (American Association for the Advancement of Science), 2005-11, Vol.310 (5750), p.1022-1025

2005

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Developing peptides therapeutics by understanding their metabolism and trafficking

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S13-S13

Cancilla, Mark

2019

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Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo

Nucleic acids research, 2010-01, Vol.38 (2), p.660

2010

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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3078-3083

2011

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Allosteric Inhibition of PTP1B Activity by Selective Modification of a Non-Active Site Cysteine Residue

Biochemistry (Easton), 2005-05, Vol.44 (21), p.7704-7712

2005

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Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

Molecular therapy. Nucleic acids, 2019-06, Vol.16, p.367-377

2019

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Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.3978-3981

2008

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Multiplex Fluorescence Microscopy Platform for High-resolution ex Vivo and in Vitro imaging to Support Correlative Tissue Distribution and Biomarker Analysis

Microscopy and microanalysis, 2020-08, Vol.26 (S2), p.586-586

2020

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RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice

Molecular pharmacology, 2011-06, Vol.79 (6), p.953-963

2011

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Fragmentation Reactions in the Mass Spectrometry Analysis of Neutral Oligosaccharides

Analytical chemistry (Washington), 1999-08, Vol.71 (15), p.3206-3218

1999

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Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2683-2686

2001

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From molecules to visuals: Empowering drug discovery and development with mass spectrometry imaging

Applying Automation and High-Throughput MALDI Mass Spectrometry for Peptide Metabolic Stability Screening

Optimization of dropletProbe-Mass Spectrometry for Whole-Body Tissue Distribution Analysis of Drug-Like Molecules

Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II

Rapid and Definitive Identification of Cyclic Peptide Soft Spots by Isotope-Labeled Reductive Dimethylation and Mass Spectrometry Fragmentation

Development and Application of DropletProbe Mass Spectrometry for Examining Biodistribution of Therapeutics

Mass spectrometry imaging of diclofenac and its metabolites in tissues using nanospray desorption electrospray ionization

Metabolite Identification of Therapeutic Peptides and Proteins by Top-down Differential Mass Spectrometry and Metabolite Database Matching

Top-Down Interrogation of Chemically Modified Oligonucleotides by Negative Electron Transfer and Collision Induced Dissociation

Differentiation of Deprotonated Acyl‑, N‑, and O‑Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates

Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Small-Molecule Inhibition of TNF-α

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Developing peptides therapeutics by understanding their metabolism and trafficking

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Allosteric Inhibition of PTP1B Activity by Selective Modification of a Non-Active Site Cysteine Residue

Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry

Multiplex Fluorescence Microscopy Platform for High-resolution ex Vivo and in Vitro imaging to Support Correlative Tissue Distribution and Biomarker Analysis

RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice

Fragmentation Reactions in the Mass Spectrometry Analysis of Neutral Oligosaccharides

Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen

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