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Pharmacological tools to target NKCC1 in brain disorders

Trends in pharmacological sciences (Regular ed.), 2021-12, Vol.42 (12), p.1009-1034

2021

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Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice

Current biology, 2019-06, Vol.29 (12), p.1938-1953.e6

2019

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Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide

Nature communications, 2022-05, Vol.13 (1), p.2747-2747, Article 2747

2022

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Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo

Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (41), p.E8770-E8779

2017

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Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity

The Journal of neuroscience, 2010-01, Vol.30 (1), p.361-371

2010

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Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

Frontiers in cellular neuroscience, 2014-05, Vol.8, p.119-119

2014

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Early depolarizing GABA controls critical-period plasticity in the rat visual cortex

Nature neuroscience, 2015-01, Vol.18 (1), p.87-96

2015

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Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation

Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5965), p.547-552

2010

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Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Scientific reports, 2017-12, Vol.7 (1), p.16825-22, Article 16825

2017

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The development of synaptic transmission is time-locked to early social behaviors in rats

Nature communications, 2019-03, Vol.10 (1), p.1195-1195, Article 1195

2019

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Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome

Journal of medicinal chemistry, 2021-07, Vol.64 (14), p.10203-10229

2021

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Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function

Neuron (Cambridge, Mass.), 2005-12, Vol.48 (5), p.773-786

2005

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Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals

Neuropharmacology, 2017-02, Vol.113 (Pt A), p.167-177

2017

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Editorial: Viral vector-based gene therapy in neurological disease: The future is now

Frontiers in neurology, 2023-02, Vol.14, p.1153681-1153681

2023

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High-performance and site-directed in utero electroporation by a triple-electrode probe

Nature communications, 2012-07, Vol.3 (1), p.960-960, Article 960

2012

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Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration

Frontiers in neuroscience, 2019-09, Vol.13, p.945-945

2019

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Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter

Nature communications, 2020-12, Vol.11 (1), p.6194-6194, Article 6194

2020

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Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1

Nature communications, 2013, Vol.4 (1), p.1800, Article 1800

2013

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GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems

Frontiers in cellular neuroscience, 2010-04, Vol.4, p.11-11

2010

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Developmental Downregulation of Histone Posttranslational Modifications Regulates Visual Cortical Plasticity

Neuron (Cambridge, Mass.), 2007-03, Vol.53 (5), p.747-759

2007

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Activity-dependent expression of Channelrhodopsin at neuronal synapses

Nature communications, 2017-11, Vol.8 (1), p.1629-14, Article 1629

2017

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Acceleration of Visual System Development by Environmental Enrichment

The Journal of neuroscience, 2004-05, Vol.24 (20), p.4840-4848

2004

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Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders

Chem, 2020-08, Vol.6 (8), p.2073-2096

2020

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A Cell Surface Biotinylation Assay to Reveal Membrane-associated Neuronal Cues: Negr1 Regulates Dendritic Arborization

Molecular & cellular proteomics, 2014-03, Vol.13 (3), p.733-748

2014

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Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever

Frontiers in cellular neuroscience, 2012, Vol.6, p.35-35

2012

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Pharmacological tools to target NKCC1 in brain disorders

Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice

Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide

Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo

Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity

Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

Early depolarizing GABA controls critical-period plasticity in the rat visual cortex

Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation

Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

The development of synaptic transmission is time-locked to early social behaviors in rats

Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome

Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function

Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals

Editorial: Viral vector-based gene therapy in neurological disease: The future is now

High-performance and site-directed in utero electroporation by a triple-electrode probe

Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration

Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter

Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1

GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems

Developmental Downregulation of Histone Posttranslational Modifications Regulates Visual Cortical Plasticity

Activity-dependent expression of Channelrhodopsin at neuronal synapses

Acceleration of Visual System Development by Environmental Enrichment

Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders

A Cell Surface Biotinylation Assay to Reveal Membrane-associated Neuronal Cues: Negr1 Regulates Dendritic Arborization

Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever

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