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Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches

Analyst (London), 2021-02, Vol.146 (3), p.747-769

2021

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Separation methods hyphenated to mass spectrometry for the characterization of the protein glycosylation at the intact level

Journal of pharmaceutical and biomedical analysis, 2020-01, Vol.178, p.112921-112921, Article 112921

2020

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Therapeutic Fc‐fusion proteins: Current analytical strategies

Journal of separation science, 2021-01, Vol.44 (1), p.35-62

2021

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Analysis of the human chorionic gonadotropin protein at the intact level by HILIC-MS and comparison with RPLC-MS

Analytical and bioanalytical chemistry, 2020-07, Vol.412 (18), p.4423-4432

2020

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Comprehensive Analysis of Photoreceptor Outer Segments: Flow Cytometry Characterization and Stress-Driven Impact on Retinal Pigment Epithelium Phagocytosis

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12889

2023

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Identification and semi-relative quantification of intact glycoforms by nano-LC–(Orbitrap)MS: application to the α-subunit of human chorionic gonadotropin and follicle-stimulating hormone

Analytical and bioanalytical chemistry, 2020-09, Vol.412 (23), p.5729-5741

2020

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Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation

mAbs, 2021-01, Vol.13 (1), p.1893427-1893427

2021

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Assessing a single-cell multi-omic analytic platform to characterize ex vivo -engineered T-cell therapy products

Frontiers in bioengineering and biotechnology, 2024-08, Vol.12, p.1417070

2024

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Challenges and Strategies for a Thorough Characterization of Antibody Acidic Charge Variants

Bioengineering (Basel), 2022-11, Vol.9 (11), p.641

2022

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Targeted Bottom-up Characterization of Recombinant Monoclonal Antibodies by Multidimensional LC/MS

Analytical chemistry (Washington), 2020-10, Vol.92 (19), p.13420-13426

2020

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Fast and Automated Characterization of Monoclonal Antibody Minor Variants from Cell Cultures by Combined Protein-A and Multidimensional LC/MS Methodologies

Analytical chemistry (Washington), 2020-06, Vol.92 (12), p.8506-8513

2020

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Development of a 3D-LC/MS Workflow for Fast, Automated, and Effective Characterization of Glycosylation Patterns of Biotherapeutic Products

Analytical chemistry (Washington), 2020-03, Vol.92 (6), p.4357-4363

2020

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Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry

Journal of Chromatography A, 2022-06, Vol.1672, p.463067, Article 463067

2022

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Physicochemical and Functional Characterization of Differential CRISPR-Cas9 Ribonucleoprotein Complexes

Analytical chemistry (Washington), 2022-01, Vol.94 (2), p.1432-1440

2022

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Monitoring multiple quality attributes of a complex Fc-fusion protein during cell culture production processes by mD-LC-MS peptide mapping

Talanta (Oxford), 2022-08, Vol.246, p.123519-123519, Article 123519

2022

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Multi‐dimensional technology – Recent advances and applications for biotherapeutic characterization

Journal of separation science, 2024-03, Vol.47 (5), p.e2300928-n/a

2024

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First profiling in hydrophilic interaction liquid chromatography of intact human chorionic gonadotropin isoforms

Journal of pharmaceutical and biomedical analysis, 2019-09, Vol.174, p.495-499

2019

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Automated middle-up approach for the characterization of biotherapeutic products by combining on-line hinge-specific digestion with RPLC-HRMS analysis

Journal of pharmaceutical and biomedical analysis, 2020-04, Vol.182, p.113130-113130, Article 113130

2020

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Assessing TCR identity, knock-in efficiency, and potency for individualized TCR-T cell therapy

Journal of immunological methods, 2023-06, Vol.517, p.113491-113491, Article 113491

2023

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Comprehensive Impurity Profiling of mRNA: Evaluating Current Technologies and Advanced Analytical Techniques

Analytical chemistry (Washington), 2024-03, Vol.96 (9), p.3886-3897

2024

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Extending the performance of FcRn and FcγRIIIa affinity liquid chromatography for protein biopharmaceuticals

Journal of Chromatography A, 2022-10, Vol.1682, p.463518, Article 463518

2022

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Novel Multidimensional Liquid Chromatography Workflow with In-Loop Enzymatic Digests of Multiple Heart-Cuts for Fast and Flexible Characterization of Biotherapeutic Protein Variants

Analytical chemistry (Washington), 2023-02, Vol.95 (7), p.3629-3637

2023

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An attempt to characterize the human Chorionic Gonadotropin protein by reversed phase liquid chromatography coupled with high-resolution mass spectrometry at the intact level

Journal of pharmaceutical and biomedical analysis, 2018-11, Vol.161, p.35-44

2018

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Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS

Talanta (Oxford), 2021-11, Vol.234, p.122628-122628, Article 122628

2021

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First characterizations by capillary electrophoresis of human Chorionic Gonadotropin at the intact level

Talanta (Oxford), 2019-02, Vol.193, p.77-86

2019

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Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches

Separation methods hyphenated to mass spectrometry for the characterization of the protein glycosylation at the intact level

Therapeutic Fc‐fusion proteins: Current analytical strategies

Analysis of the human chorionic gonadotropin protein at the intact level by HILIC-MS and comparison with RPLC-MS

Comprehensive Analysis of Photoreceptor Outer Segments: Flow Cytometry Characterization and Stress-Driven Impact on Retinal Pigment Epithelium Phagocytosis

Identification and semi-relative quantification of intact glycoforms by nano-LC–(Orbitrap)MS: application to the α-subunit of human chorionic gonadotropin and follicle-stimulating hormone

Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation

Assessing a single-cell multi-omic analytic platform to characterize ex vivo -engineered T-cell therapy products

Challenges and Strategies for a Thorough Characterization of Antibody Acidic Charge Variants

Targeted Bottom-up Characterization of Recombinant Monoclonal Antibodies by Multidimensional LC/MS

Fast and Automated Characterization of Monoclonal Antibody Minor Variants from Cell Cultures by Combined Protein-A and Multidimensional LC/MS Methodologies

Development of a 3D-LC/MS Workflow for Fast, Automated, and Effective Characterization of Glycosylation Patterns of Biotherapeutic Products

Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry

Physicochemical and Functional Characterization of Differential CRISPR-Cas9 Ribonucleoprotein Complexes

Monitoring multiple quality attributes of a complex Fc-fusion protein during cell culture production processes by mD-LC-MS peptide mapping

Multi‐dimensional technology – Recent advances and applications for biotherapeutic characterization

First profiling in hydrophilic interaction liquid chromatography of intact human chorionic gonadotropin isoforms

Automated middle-up approach for the characterization of biotherapeutic products by combining on-line hinge-specific digestion with RPLC-HRMS analysis

Assessing TCR identity, knock-in efficiency, and potency for individualized TCR-T cell therapy

Comprehensive Impurity Profiling of mRNA: Evaluating Current Technologies and Advanced Analytical Techniques

Extending the performance of FcRn and FcγRIIIa affinity liquid chromatography for protein biopharmaceuticals

Novel Multidimensional Liquid Chromatography Workflow with In-Loop Enzymatic Digests of Multiple Heart-Cuts for Fast and Flexible Characterization of Biotherapeutic Protein Variants

An attempt to characterize the human Chorionic Gonadotropin protein by reversed phase liquid chromatography coupled with high-resolution mass spectrometry at the intact level

Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS

First characterizations by capillary electrophoresis of human Chorionic Gonadotropin at the intact level

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