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Drug Disposition Classification Systems in Discovery and Development: A Comparative Review of the BDDCS, ECCS and ECCCS Concepts

Pharmaceutical research, 2016-11, Vol.33 (11), p.2583-2593

Camenisch, Gian P.

2016

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Precision Measurements in Few-Electron Molecules: The Ionization Energy of Metastable He 4 2 and the First Rotational Interval of He 4 2

Physical review letters, 2020-05, Vol.124 (21), Article 213001

2020

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Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data

Drug metabolism and disposition, 2014-09, Vol.42 (9), p.1514-1521

2014

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Quantifying proton NMR coherent linewidth in proteins under fast MAS conditions: a second moment approach

Physical chemistry chemical physics : PCCP, 2019, Vol.21 (35), p.1885-18865

2019

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Pulsed dynamic nuclear polarization: a comprehensive Floquet description

Physical chemistry chemical physics : PCCP, 2024-06, Vol.26 (25), p.17666-17683

2024

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Novel In Vitro-In Vivo Extrapolation (IVIVE) Method to Predict Hepatic Organ Clearance in Rat

Pharmaceutical research, 2012-02, Vol.29 (2), p.603-617

2012

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Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions

Biopharmaceutics & drug disposition, 2012-05, Vol.33 (4), p.179-194

2012

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Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism

Drug metabolism and disposition, 2018-07, Vol.46 (7), p.1001-1013

2018

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In Vitro–In Vivo Extrapolation Method to Predict Human Renal Clearance of Drugs

Journal of pharmaceutical sciences, 2014-03, Vol.103 (3), p.994-1001

2014

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Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)

Drug metabolism letters, 2019, Vol.13 (1), p.53-63

2019

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New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data

European journal of pharmaceutical sciences, 2016-04, Vol.86, p.96-102

2016

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Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins

Drug metabolism and personalized therapy, 2015-09, Vol.30 (3), p.175-188

2015

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P174 - Absorption, distribution, metabolism, and excretion of tropifexor, a potent FXR agonist for the treatment of NASH, following a single oral 1 mg dose of [14C]tropifexor in healthy male subjects

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S76-S76

2020

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Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridar

Pharmaceutical research, 2007-09, Vol.24 (9), p.1720-1728

2007

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An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data

Pharmacology research & perspectives, 2020-06, Vol.8 (3), p.e00599-n/a

2020

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Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction

Drug metabolism and personalized therapy, 2016-12, Vol.31 (4), p.221-228

2016

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Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight

European journal of pharmaceutical sciences, 1998-10, Vol.6 (4), p.313-319

1998

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Estimation of Blood-Brain Barrier Crossing of Drugs Using Molecular Size and Shape, and H-Bonding Descriptors

Journal of drug targeting, 1998, Vol.6 (2), p.151-165

1998

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In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex Fe-[ICL670]2 for rat, marmoset, rabbit, mouse, dog, and human

Drug metabolism and disposition, 2006-06, Vol.34 (6), p.971-975

2006

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Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2805-2814

2017

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Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters

Biochemical pharmacology, 2012-10, Vol.84 (8), p.1096-1102

2012

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Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.523-531

2017

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Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite

Drug metabolism and disposition, 2020-10, Vol.48 (10), p.873-885

2020

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In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics

European journal of clinical pharmacology, 2018-04, Vol.74 (4), p.455-464

2018

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Influence of hydroxyurea on imatinib mesylate (gleevec) transport at the mouse blood-brain barrier

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.1945-1949

2006

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Drug Disposition Classification Systems in Discovery and Development: A Comparative Review of the BDDCS, ECCS and ECCCS Concepts

Precision Measurements in Few-Electron Molecules: The Ionization Energy of Metastable He 4 2 and the First Rotational Interval of He 4 2

Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data

Quantifying proton NMR coherent linewidth in proteins under fast MAS conditions: a second moment approach

Pulsed dynamic nuclear polarization: a comprehensive Floquet description

Novel In Vitro-In Vivo Extrapolation (IVIVE) Method to Predict Hepatic Organ Clearance in Rat

Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions

Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism

In Vitro–In Vivo Extrapolation Method to Predict Human Renal Clearance of Drugs

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)

New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data

Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins

P174 - Absorption, distribution, metabolism, and excretion of tropifexor, a potent FXR agonist for the treatment of NASH, following a single oral 1 mg dose of [14C]tropifexor in healthy male subjects

Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridar

An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data

Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction

Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight

Estimation of Blood-Brain Barrier Crossing of Drugs Using Molecular Size and Shape, and H-Bonding Descriptors

In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex Fe-[ICL670]2 for rat, marmoset, rabbit, mouse, dog, and human

Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations

Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters

Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations

Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite

In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics

Influence of hydroxyurea on imatinib mesylate (gleevec) transport at the mouse blood-brain barrier

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