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Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan

Cephalalgia, 2010-10, Vol.30 (10), p.1159-1169

2010

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CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography

Neuropharmacology, 2013-03, Vol.66, p.89-98

2013

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A review of the abuse potential assessment of atomoxetine: a nonstimulant medication for attention-deficit/hyperactivity disorder

Psychopharmacology, 2013-03, Vol.226 (2), p.189-200

2013

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Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine

Neuropsychopharmacology (New York, N.Y.), 1996-02, Vol.14 (2), p.87-96

1996

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Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039)

The Journal of pharmacology and experimental therapeutics, 2007-04, Vol.321 (1), p.308-317

2007

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

The Journal of neuroscience, 2011-11, Vol.31 (46), p.16507-16516

2011

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Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo

The Journal of pharmacology and experimental therapeutics, 2006-08, Vol.318 (2), p.772

2006

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Olanzapine: a basic science update

British journal of psychiatry, 1999-02, Vol.174 (S37), p.36-40

1999

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Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor

The Journal of biological chemistry, 2003-11, Vol.278 (46), p.46107-46116

2003

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Preclinical pharmacology of FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: a potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine

The Journal of pharmacology and experimental therapeutics, 2005-12, Vol.315 (3), p.1265

2005

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A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data

International journal of geriatric psychiatry, 2001-12, Vol.16 (S1), p.S33-S61

2001

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Muscarinic mechanisms of antipsychotic atypicality

Progress in neuro-psychopharmacology & biological psychiatry, 2003-10, Vol.27 (7), p.1125-1143

2003

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Synthesis and Structure−Activity Relationships of Potent and Orally Active 5-HT4 Receptor Antagonists: Indazole and Benzimidazolone Derivatives

Journal of medicinal chemistry, 1998-05, Vol.41 (11), p.1943-1955

1998

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Pulmonary safety profile of a Transient Receptor Potential Vanilloid-1 (TRPV1) agonist in guinea-pigs

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e57-e57

2011

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In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders

Psychopharmacologia, 2006-04, Vol.185 (2), p.240-247

2006

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Indoloxypropanolamine analogues as 5-HT1A receptor antagonists

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5600-5604

2007

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Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine

Life sciences (1973), 1997-10, Vol.61 (21), p.2117-2126

1997

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Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.901

1999

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The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance

Schizophrenia research, 2001-04, Vol.49 (1), p.193-201

2001

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Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice

European journal of pharmacology, 2000-08, Vol.402 (3), p.241-246

2000

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N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: A Potent, Selective, and Orally Active 5-HT1F Receptor Agonist Potentially Useful for Migraine Therapy

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4031-4034

2001

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Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

European journal of pharmacology, 1998-09, Vol.356 (2), p.109-119

1998

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Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo

Brain research, 2001-10, Vol.916 (1), p.165-171

2001

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Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4378-4384

1998

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Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan

CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography

A review of the abuse potential assessment of atomoxetine: a nonstimulant medication for attention-deficit/hyperactivity disorder

Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine

Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039)

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo

Olanzapine: a basic science update

Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor

Preclinical pharmacology of FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: a potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine

A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data

Muscarinic mechanisms of antipsychotic atypicality

Synthesis and Structure−Activity Relationships of Potent and Orally Active 5-HT4 Receptor Antagonists: Indazole and Benzimidazolone Derivatives

Pulmonary safety profile of a Transient Receptor Potential Vanilloid-1 (TRPV1) agonist in guinea-pigs

In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders

Indoloxypropanolamine analogues as 5-HT1A receptor antagonists

Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine

Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance

Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice

N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: A Potent, Selective, and Orally Active 5-HT1F Receptor Agonist Potentially Useful for Migraine Therapy

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo

Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity

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