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Modeling neurodegeneration in Caenorhabditis elegans

Disease models & mechanisms, 2020-10, Vol.13 (10)

2020

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Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

Cell, 2011-07, Vol.146 (1), p.37-52

2011

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Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model

Disease models & mechanisms, 2023-06, Vol.16 (6)

Caldwell, Guy A

2023

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Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events

Cell, 2014-01, Vol.156 (1-2), p.170-182

2014

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Lysosomal impairment in Parkinson's disease

Movement disorders, 2013-06, Vol.28 (6), p.725-732

2013

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Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (11), p.4013-4018

2014

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Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.E3976-E3985

2014

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The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson’s Models

Cell metabolism, 2014-07, Vol.20 (1), p.145-157

2014

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Calcineurin determines toxic versus beneficial responses to α-synuclein

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (34), p.E3544-E3552

2014

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Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (1), p.145-150

2008

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Hypothesis-Based RNAi Screening Identifies Neuroprotective Genes in a Parkinson's Disease Model

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (2), p.728-733

2008

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Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans

PLoS genetics, 2022-08, Vol.18 (8), p.e1010115

2022

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RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway

The Journal of neuroscience, 2014-11, Vol.34 (48), p.16076-16085

2014

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Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson's Disease

Brain sciences, 2019-03, Vol.9 (4), p.73

2019

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Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

Human molecular genetics, 2011-10, Vol.20 (20), p.3933-3942

2011

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Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

International journal of molecular sciences, 2019-06, Vol.20 (13), p.3202

2019

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Identifying transgene insertions in Caenorhabditis elegans genomes with Oxford Nanopore sequencing

PeerJ (San Francisco, CA), 2024-09, Vol.12, p.e18100, Article e18100

2024

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Therapeutic genetic variation revealed in diverse Hsp104 homologs

eLife, 2020-12, Vol.9

2020

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ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

Disease models & mechanisms, 2019-02, Vol.12 (2)

2019

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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

Molecular brain, 2008-11, Vol.1 (1), p.17-17, Article 17

2008

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Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease

PloS one, 2016-10, Vol.11 (10), p.e0164465

2016

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VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease

Neurobiology of disease, 2010-02, Vol.37 (2), p.330-338

2010

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Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

Human molecular genetics, 2015-03, Vol.24 (5), p.1322-1335

2015

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The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response

Human molecular genetics, 2010-09, Vol.19 (18), p.3502-3515

2010

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Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans

Cells (Basel, Switzerland), 2023-04, Vol.12 (8), p.1170

2023

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Modeling neurodegeneration in Caenorhabditis elegans

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model

Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events

Lysosomal impairment in Parkinson's disease

Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson’s Models

Calcineurin determines toxic versus beneficial responses to α-synuclein

Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

Hypothesis-Based RNAi Screening Identifies Neuroprotective Genes in a Parkinson's Disease Model

Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans

RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson's Disease

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

Identifying transgene insertions in Caenorhabditis elegans genomes with Oxford Nanopore sequencing

Therapeutic genetic variation revealed in diverse Hsp104 homologs

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response

Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans

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