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Disulfide Prodrugs of Albitiazolium (T3/SAR97276): Synthesis and Biological Activities

Journal of medicinal chemistry, 2012-05, Vol.55 (10), p.4619-4628

2012

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A Class of Potent Antimalarials and Their Specific Accumulation in Infected Erythrocytes

Science (American Association for the Advancement of Science), 2002-02, Vol.295 (5558), p.1311-1314

2002

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Potent Antimalarial Activity of 2-Aminopyridinium Salts, Amidines, and Guanidines

Journal of medicinal chemistry, 2007-12, Vol.50 (25), p.6307-6315

2007

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Prodrugs of Bisthiazolium Salts Are Orally Potent Antimalarials

Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (43), p.15458-15463

2004

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Potent Inhibitors of Plasmodium Phospholipid Metabolism with a Broad Spectrum of In Vitro Antimalarial Activities

Antimicrobial Agents and Chemotherapy, 2003-08, Vol.47 (8), p.2590-2597

2003

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In Vivo Antimalarial Activities of Mono- and Bis Quaternary Ammonium Salts Interfering with Plasmodium Phospholipid Metabolism

Antimicrobial Agents and Chemotherapy, 2003-08, Vol.47 (8), p.2598-2605

2003

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Potent Antihematozoan Activity of Novel Bisthiazolium Drug T16: Evidence for Inhibition of Phosphatidylcholine Metabolism in Erythrocytes Infected with Babesia and Plasmodium spp

Antimicrobial Agents and Chemotherapy, 2006-10, Vol.50 (10), p.3381-3388

2006

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Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums

Antimicrobial Agents and Chemotherapy, 2003-08, Vol.47 (8), p.2584-2589

2003

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Mono- and Bis-Thiazolium Salts Have Potent Antimalarial Activity

Journal of medicinal chemistry, 2005-05, Vol.48 (10), p.3639-3643

2005

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Pharmacological Properties of a New Antimalarial Bisthiazolium Salt, T3, and a Corresponding Prodrug, TE3

Antimicrobial Agents and Chemotherapy, 2005-09, Vol.49 (9), p.3631-3639

2005

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Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (13), p.3953-3956

2010

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Unraveling the Mode of Action of the Antimalarial Choline Analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae

Antimicrobial Agents and Chemotherapy, 2004-08, Vol.48 (8), p.2816-2824

2004

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Antimalarial activity of 77 phospholipid polar head analogs : Close correlation between inhibition of phospholipid metabolism and in vitro Plasmodium falciparum growth

Blood, 1998-02, Vol.91 (4), p.1426-1437

1998

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Synthesis and antimalarial activity of new 1,12-bis( N, N′-acetamidinyl)dodecane derivatives

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.593-596

2007

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Dual molecules as new antimalarials

Combinatorial chemistry & high throughput screening, 2005-02, Vol.8 (1), p.49-62

2005

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Quantification of Antimalarial Bisthiazolium Compounds and Their Neutral Bioprecursors in Plasma by Liquid Chromatography-Electrospray Mass Spectrometry

Clinical chemistry (Baltimore, Md.), 2005-03, Vol.51 (3), p.593-602

2005

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Synthesis and Evaluation of Bis-Thiazolium Salts as Potential Antimalarial Drugs

ChemMedChem, 2010-07, Vol.5 (7), p.1102-1109

2010

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Liquid chromatography-electrospray mass spectrometry determination of a bis-thiazolium compound with potent antimalarial activity and its neutral bioprecursor in human plasma, whole blood and red blood cells

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-06, Vol.820 (1), p.83-93

2005

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Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums

Antimicrobial agents and chemotherapy, 2003-10, Vol.47 (10), p.3376-3376

2003

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Solution Parallel Synthesis of Cyclic Guanidines

Heterocycles, 2000-06, Vol.53 (6), p.1317

2000

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Antimalarial Activity of Compounds Interfering with Plasmodium falciparum Phospholipid Metabolism: Comparison between Mono- and Bisquaternary Ammonium Salts

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.505-516

2000

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Synthesis and Evaluation of Bis-Thiazolium Salts as Potential Antimalarial Drug

ChemMedChem, 2010, Vol.5, p.1102-1109

2010

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Exploration of potential prodrug approach of the bis-thiazolium salts T and T4 for orally delivered antimalarials

Bioorganic & medicinal chemistry letters, 2010, Vol.20, p.3953-3956

2010

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Antimalarial Activity of Molecules Interfering with Plasmodium falciparum Phospholipid Metabolism. Structure−Activity Relationship Analysis

Journal of medicinal chemistry, 1997-10, Vol.40 (22), p.3557-3566

1997

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Present development concerning antimalarial activity of phospholipid metabolism inhibitors with special reference to in vivo activity

Memórias do Instituto Oswaldo Cruz, 1994, Vol.89 Suppl 2 (suppl 2), p.85-90

1994

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Disulfide Prodrugs of Albitiazolium (T3/SAR97276): Synthesis and Biological Activities

A Class of Potent Antimalarials and Their Specific Accumulation in Infected Erythrocytes

Potent Antimalarial Activity of 2-Aminopyridinium Salts, Amidines, and Guanidines

Prodrugs of Bisthiazolium Salts Are Orally Potent Antimalarials

Potent Inhibitors of Plasmodium Phospholipid Metabolism with a Broad Spectrum of In Vitro Antimalarial Activities

In Vivo Antimalarial Activities of Mono- and Bis Quaternary Ammonium Salts Interfering with Plasmodium Phospholipid Metabolism

Potent Antihematozoan Activity of Novel Bisthiazolium Drug T16: Evidence for Inhibition of Phosphatidylcholine Metabolism in Erythrocytes Infected with Babesia and Plasmodium spp

Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums

Mono- and Bis-Thiazolium Salts Have Potent Antimalarial Activity

Pharmacological Properties of a New Antimalarial Bisthiazolium Salt, T3, and a Corresponding Prodrug, TE3

Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials

Unraveling the Mode of Action of the Antimalarial Choline Analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae

Antimalarial activity of 77 phospholipid polar head analogs : Close correlation between inhibition of phospholipid metabolism and in vitro Plasmodium falciparum growth

Synthesis and antimalarial activity of new 1,12-bis( N, N′-acetamidinyl)dodecane derivatives

Dual molecules as new antimalarials

Quantification of Antimalarial Bisthiazolium Compounds and Their Neutral Bioprecursors in Plasma by Liquid Chromatography-Electrospray Mass Spectrometry

Synthesis and Evaluation of Bis-Thiazolium Salts as Potential Antimalarial Drugs

Liquid chromatography-electrospray mass spectrometry determination of a bis-thiazolium compound with potent antimalarial activity and its neutral bioprecursor in human plasma, whole blood and red blood cells

Heme Binding Contributes to Antimalarial Activity of Bis-Quaternary Ammoniums

Solution Parallel Synthesis of Cyclic Guanidines

Antimalarial Activity of Compounds Interfering with Plasmodium falciparum Phospholipid Metabolism: Comparison between Mono- and Bisquaternary Ammonium Salts

Synthesis and Evaluation of Bis-Thiazolium Salts as Potential Antimalarial Drug

Exploration of potential prodrug approach of the bis-thiazolium salts T and T4 for orally delivered antimalarials

Antimalarial Activity of Molecules Interfering with Plasmodium falciparum Phospholipid Metabolism. Structure−Activity Relationship Analysis

Present development concerning antimalarial activity of phospholipid metabolism inhibitors with special reference to in vivo activity

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