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Catalytic Asymmetric Synthesis of a Tertiary Benzylic Carbon Center via Phenol-Directed Alkene Hydrogenation

Journal of organic chemistry, 2011-07, Vol.76 (13), p.5198-5206

2011

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Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical Industry

Journal of organic chemistry, 2019-04, Vol.84 (8), p.4583-4603

2019

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Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate

Organic process research & development, 2022-09, Vol.26 (9), p.2629-2635

2022

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Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib ManufactureWhat a Difference a Base Makes

Organic process research & development, 2023-01, Vol.27 (1), p.198-205

2023

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Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid

Journal of organic chemistry, 2022-02, Vol.87 (4), p.1977-1985

2022

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Hazard Evaluation and Safety Considerations for Scale-Up of a Fuming Nitric Acid Mediated Nitration of Aryl Boronic Acids

Organic process research & development, 2022-03, Vol.26 (3), p.657-660

2022

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Structural Elucidation and Absolute Stereochemistry for Pharma Compounds Using MicroED

Organic letters, 2024-08

2024

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Kinetic Investigations To Enable Development of a Robust Radical Benzylic Bromination for Commercial Manufacturing of AMG 423 Dihydrochloride Hydrate

Organic process research & development, 2020-08, Vol.24 (8), p.1523-1530

2020

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Development of a Continuous Photochemical Bromination/Alkylation Sequence En Route to AMG 423

Organic process research & development, 2022-02, Vol.26 (2), p.458-466

2022

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Mechanistic Insights into the Racemization of Fused Cyclopropyl Isoxazolines

Organic letters, 2020-03, Vol.22 (6), p.2113-2117

2020

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Synthesis of Substituted Pyridines via Formal (3+3) Cycloaddition of Enamines with Unsaturated Aldehydes and Ketones

Journal of organic chemistry, 2022-07, Vol.87 (13), p.8437-8444

2022

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Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor

Organic process research & development, 2022-11, Vol.26 (11), p.3115-3125

2022

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Highly Enantioselective Hydrogenation of Styrenes Directed by 2′-Hydroxyl Groups

Organic letters, 2011-04, Vol.13 (7), p.1881-1883

2011

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Development of a Robust and Highly Selective Ru(II)-Catalyzed Dynamic Kinetic Resolution Used to Manufacture AMG 232

Organic process research & development, 2020-06, Vol.24 (6), p.1164-1174

2020

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Development of a Commercial Process To Prepare AMG 232 Using a Green Ozonolysis–Pinnick Tandem Transformation

Journal of organic chemistry, 2019-04, Vol.84 (8), p.4763-4779

2019

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Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS G12C Inhibitor

Organic process research & development, 2022-11, Vol.26 (11), p.3115-3125

2022

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Green Chemistry as a Driver for Innovation in the Pharmaceutical Industry

Israel journal of chemistry, 2021-07, Vol.61 (7-8), p.369-379

2021

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Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

ACS chemical biology, 2016-10, Vol.11 (10), p.2734-2743

2016

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Telescoped Process to Manufacture 6,6,6-Trifluorofucose via Diastereoselective Transfer Hydrogenation: Scalable Access to an Inhibitor of Fucosylation Utilized in Monoclonal Antibody Production

Journal of organic chemistry, 2016-06, Vol.81 (11), p.4736-4743

2016

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Diastereoselective Palladium-Catalyzed α-Arylation of 4-Substituted Cyclohexyl Esters

Organic letters, 2008-11, Vol.10 (22), p.5251-5254

2008

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Two Asymmetric Syntheses of AMG 221, an Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1

Journal of organic chemistry, 2009-05, Vol.74 (10), p.3833-3842

2009

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Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model

Journal of medicinal chemistry, 2008-07, Vol.51 (13), p.3953-3960

2008

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New Methods for the Synthesis of 2-Aminothiazolones

Journal of organic chemistry, 2008-03, Vol.73 (5), p.2003-2006

2008

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Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1446-1450

2009

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Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.405-410

2011

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Catalytic Asymmetric Synthesis of a Tertiary Benzylic Carbon Center via Phenol-Directed Alkene Hydrogenation

Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical Industry

Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate

Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib ManufactureWhat a Difference a Base Makes

Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid

Hazard Evaluation and Safety Considerations for Scale-Up of a Fuming Nitric Acid Mediated Nitration of Aryl Boronic Acids

Structural Elucidation and Absolute Stereochemistry for Pharma Compounds Using MicroED

Kinetic Investigations To Enable Development of a Robust Radical Benzylic Bromination for Commercial Manufacturing of AMG 423 Dihydrochloride Hydrate

Development of a Continuous Photochemical Bromination/Alkylation Sequence En Route to AMG 423

Mechanistic Insights into the Racemization of Fused Cyclopropyl Isoxazolines

Synthesis of Substituted Pyridines via Formal (3+3) Cycloaddition of Enamines with Unsaturated Aldehydes and Ketones

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor

Highly Enantioselective Hydrogenation of Styrenes Directed by 2′-Hydroxyl Groups

Development of a Robust and Highly Selective Ru(II)-Catalyzed Dynamic Kinetic Resolution Used to Manufacture AMG 232

Development of a Commercial Process To Prepare AMG 232 Using a Green Ozonolysis–Pinnick Tandem Transformation

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS G12C Inhibitor

Green Chemistry as a Driver for Innovation in the Pharmaceutical Industry

Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

Telescoped Process to Manufacture 6,6,6-Trifluorofucose via Diastereoselective Transfer Hydrogenation: Scalable Access to an Inhibitor of Fucosylation Utilized in Monoclonal Antibody Production

Diastereoselective Palladium-Catalyzed α-Arylation of 4-Substituted Cyclohexyl Esters

Two Asymmetric Syntheses of AMG 221, an Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1

Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model

New Methods for the Synthesis of 2-Aminothiazolones

Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

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