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A2A Adenosine Receptor Antagonists as Therapeutic Candidates: Are They Still an Interesting Challenge?

Mini reviews in medicinal chemistry, 2018, Vol.18 (14), p.1168-1174

2018

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Carbon Nanotube Substrates Boost Neuronal Electrical Signaling

Nano letters, 2005-06, Vol.5 (6), p.1107-1110

2005

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Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3- c ]pyridine Scaffold

Molecules (Basel, Switzerland), 2020-04, Vol.25 (7), p.1690

2020

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Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists

Current topics in medicinal chemistry, 2016-11, Vol.16 (28), p.3224-3257

2016

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Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents

Pharmaceutics, 2022-06, Vol.14 (6), p.1191

2022

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Schematic overview of oligosaccharides, with survey on their major physiological effects and a focus on milk ones

Carbohydrate polymer technologies and applications, 2020-12, Vol.1, p.100013, Article 100013

2020

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Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.1225-1238

2018

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The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives

PloS one, 2015-12, Vol.10 (12), p.e0143504

2015

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Non Peptidic αvβ3 Antagonists: Recent Developments

Current medicinal chemistry, 2005-01, Vol.12 (1), p.51-70

2005

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Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2019-01, Vol.15 (8), p.863-872

2019

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Synthesis, Biological Activity, and Molecular Modeling Investigation of New Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Human A3 Adenosine Receptor Antagonists

Journal of medicinal chemistry, 2002-02, Vol.45 (4), p.770-780

2002

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Oligonucleotides and oligonucleotide conjugates: a new approach for cancer treatment

Current medicinal chemistry, 2005, Vol.12 (1), p.71-88

2005

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Chemical and biological versatility of pyrazolo[3,4- d ]pyrimidines: one scaffold, multiple modes of action

Future medicinal chemistry, 2023-12, Vol.15 (23), p.2143-2148

2023

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[3H]MRE 3008F20: A Novel Antagonist Radioligand for the Pharmacological and Biochemical Characterization of Human A3 Adenosine Receptors

Molecular pharmacology, 2000-05, Vol.57 (5), p.968

2000

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Thio-substituted derivatives of 4-amino-pyrazolo[3,4-d]pyrimidine-6-thiol as antiproliferative agents

Future medicinal chemistry, 2021-09, Vol.13 (18), p.1515-1530

2021

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Synthesis, Biological Properties, and Molecular Modeling Investigation of the First Potent, Selective, and Water-Soluble Human A3 Adenosine Receptor Antagonist

Journal of medicinal chemistry, 2002-08, Vol.45 (17), p.3579-3582

2002

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Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Adenosine Receptor Antagonists. Influence of the N5 Substituent on the Affinity at the Human A3 and A2B Adenosine Receptor Subtypes: A Molecular Modeling Investigation

Journal of medicinal chemistry, 2003-09, Vol.46 (20), p.4287-4296

2003

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Medicinal chemistry of A2A adenosine receptor antagonists

Current topics in medicinal chemistry, 2003, Vol.3 (4), p.403-411

2003

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6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (13), p.4612-4621

2009

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5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors

European journal of medicinal chemistry, 2016-01, Vol.108, p.529-541

2016

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Effect of A-Ring Modifications on the DNA-Binding Behavior and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines

Journal of medicinal chemistry, 1999-06, Vol.42 (11), p.1951-1964

1999

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Scaffold Decoration at Positions 5 and 8 of 1,2,4-Triazolo[1,5‑c]Pyrimidines to Explore the Antagonist Profiling on Adenosine Receptors: A Preliminary Structure–Activity Relationship Study

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.6210-6225

2014

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Pyrazolo-triazolo-pyrimidine derivatives as adenosine receptor antagonists: a possible template for adenosine receptor subtypes?

Current pharmaceutical design, 2002-01, Vol.8 (26), p.2299-2332

2002

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Exploring the Directionality of 5‑Substitutions in a New Series of 5‑Alkylaminopyrazolo[4,3‑e]1,2,4-triazolo[1,5‑c]pyrimidine as a Strategy To Design Novel Human A3 Adenosine Receptor Antagonists

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9654-9668

2012

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Solid Lipid Microparticles for the Stability Enhancement of a Dopamine Prodrug

Journal of pharmaceutical sciences, 2010-11, Vol.99 (11), p.4730-4737

2010

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A2A Adenosine Receptor Antagonists as Therapeutic Candidates: Are They Still an Interesting Challenge?

Carbon Nanotube Substrates Boost Neuronal Electrical Signaling

Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3- c ]pyridine Scaffold

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists

Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents

Schematic overview of oligosaccharides, with survey on their major physiological effects and a focus on milk ones

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach

The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives

Non Peptidic αvβ3 Antagonists: Recent Developments

Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

Synthesis, Biological Activity, and Molecular Modeling Investigation of New Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Human A3 Adenosine Receptor Antagonists

Oligonucleotides and oligonucleotide conjugates: a new approach for cancer treatment

Chemical and biological versatility of pyrazolo[3,4- d ]pyrimidines: one scaffold, multiple modes of action

[3H]MRE 3008F20: A Novel Antagonist Radioligand for the Pharmacological and Biochemical Characterization of Human A3 Adenosine Receptors

Thio-substituted derivatives of 4-amino-pyrazolo[3,4-d]pyrimidine-6-thiol as antiproliferative agents

Synthesis, Biological Properties, and Molecular Modeling Investigation of the First Potent, Selective, and Water-Soluble Human A3 Adenosine Receptor Antagonist

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Adenosine Receptor Antagonists. Influence of the N5 Substituent on the Affinity at the Human A3 and A2B Adenosine Receptor Subtypes: A Molecular Modeling Investigation

Medicinal chemistry of A2A adenosine receptor antagonists

6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors

5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors

Effect of A-Ring Modifications on the DNA-Binding Behavior and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines

Scaffold Decoration at Positions 5 and 8 of 1,2,4-Triazolo[1,5‑c]Pyrimidines to Explore the Antagonist Profiling on Adenosine Receptors: A Preliminary Structure–Activity Relationship Study

Pyrazolo-triazolo-pyrimidine derivatives as adenosine receptor antagonists: a possible template for adenosine receptor subtypes?

Exploring the Directionality of 5‑Substitutions in a New Series of 5‑Alkylaminopyrazolo[4,3‑e]1,2,4-triazolo[1,5‑c]pyrimidine as a Strategy To Design Novel Human A3 Adenosine Receptor Antagonists

Solid Lipid Microparticles for the Stability Enhancement of a Dopamine Prodrug

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