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Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes

Current issues in molecular biology, 2022-03, Vol.44 (4), p.1452-1462

2022

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Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging

Mechanisms of ageing and development, 2012-04, Vol.133 (4), p.133-137

2012

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The Timing and Duration of Folate Restriction Differentially Impacts Colon Carcinogenesis

Nutrients, 2021-12, Vol.14 (1), p.16

2021

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Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction

American Journal of Physiology: Cell Physiology, 2007-11, Vol.293 (5), p.C1669-C1678

2007

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A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions

PLoS genetics, 2007-08, Vol.3 (8), p.e134-e134

2007

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Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance

Cellular and molecular life sciences : CMLS, 2012-03, Vol.69 (5), p.727-740

Cabelof, Diane C.

2012

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Folate and Colorectal Cancer in Rodents: A Model of DNA Repair Deficiency

Journal of Oncology, 2012-01, Vol.2012 (2012), p.133-149-016

2012

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Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism

Experimental gerontology, 2021-07, Vol.150, p.111387-111387, Article 111387

2021

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Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

Blood, 2009-09, Vol.114 (13), p.2753-2763

2009

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Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice

Free radical biology & medicine, 2009-06, Vol.46 (11), p.1488-1499

2009

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Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related decline

DNA repair, 2003-03, Vol.2 (3), p.295-307

2003

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Induction of DNA polymerase β-dependent base excision repair in response to oxidative stress in vivo

Carcinogenesis (New York), 2002-09, Vol.23 (9), p.1419-1425

2002

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Base excision repair deficiency caused by polymerase β haploinsufficiency: Accelerated DNA damage and increased mutational response to carcinogens

Cancer research (Chicago, Ill.), 2003-09, Vol.63 (18), p.5799-5807

2003

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Haploinsufficiency in DNA polymerase β increases cancer risk with age and alters mortality rate

Cancer research (Chicago, Ill.), 2006-08, Vol.66 (15), p.7460-7465

2006

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Age-Related Loss of the DNA Repair Response Following Exposure to Oxidative Stress

The journals of gerontology. Series A, Biological sciences and medical sciences, 2006-05, Vol.61 (5), p.427-434

2006

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Folate deficiency regulates expression of DNA polymerase β in response to oxidative stress

Free radical biology & medicine, 2011-01, Vol.50 (2), p.270-280

2011

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Aging alters folate homeostasis and DNA damage response in colon

Mechanisms of ageing and development, 2012-02, Vol.133 (2-3), p.75-82

2012

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Folate Deficiency Provides Protection against Colon Carcinogenesis in DNA Polymerase β Haploinsufficient Mice

The Journal of biological chemistry, 2010-06, Vol.285 (25), p.19246-19258

2010

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Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates

The Journal of biological chemistry, 2005-02, Vol.280 (7), p.5588-5597

2005

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Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age

Mechanisms of ageing and development, 2009-09, Vol.130 (9), p.637-647

2009

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Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair

The Journal of biological chemistry, 2004-04, Vol.279 (18), p.18425-18433

2004

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Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency

The Journal of biological chemistry, 2004-08, Vol.279 (35), p.36504-36513

2004

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A sensitive biochemical assay for the detection of uracil

Environmental and molecular mutagenesis, 2006-01, Vol.47 (1), p.31-37

2006

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Structure and Regulation of the Murine Reduced Folate Carrier Gene

The Journal of biological chemistry, 2005-02, Vol.280 (7), p.5588-5597

2005

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Uracil accumulation induced by folate depletion is dependent on uracil DNA glycosylase (UDG) activity

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Biological And Medical Sciences
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Dna Polymerase Beta - Genetics
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Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes

Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging

The Timing and Duration of Folate Restriction Differentially Impacts Colon Carcinogenesis

Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction

A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions

Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance

Folate and Colorectal Cancer in Rodents: A Model of DNA Repair Deficiency

Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice

Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related decline

Induction of DNA polymerase β-dependent base excision repair in response to oxidative stress in vivo

Base excision repair deficiency caused by polymerase β haploinsufficiency: Accelerated DNA damage and increased mutational response to carcinogens

Haploinsufficiency in DNA polymerase β increases cancer risk with age and alters mortality rate

Age-Related Loss of the DNA Repair Response Following Exposure to Oxidative Stress

Folate deficiency regulates expression of DNA polymerase β in response to oxidative stress

Aging alters folate homeostasis and DNA damage response in colon

Folate Deficiency Provides Protection against Colon Carcinogenesis in DNA Polymerase β Haploinsufficient Mice

Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates

Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age

Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair

Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency

A sensitive biochemical assay for the detection of uracil

Structure and Regulation of the Murine Reduced Folate Carrier Gene

Uracil accumulation induced by folate depletion is dependent on uracil DNA glycosylase (UDG) activity

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