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Caenorhabditis elegans Dosage Compensation Regulates Histone H4 Chromatin State on X Chromosomes

Molecular and Cellular Biology, 2012-05, Vol.32 (9), p.1710-1719

2012

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Cordon-Bleu Is an Actin Nucleation Factor and Controls Neuronal Morphology

Cell, 2007-10, Vol.131 (2), p.337-350

2007

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Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities

Regulatory toxicology and pharmacology, 2013-10, Vol.67 (1), p.39-52

2013

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Application of the adverse outcome pathway framework to genotoxic modes of action

Environmental and molecular mutagenesis, 2020-01, Vol.61 (1), p.114-134

2020

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The onset of C. elegans dosage compensation is linked to the loss of developmental plasticity

Developmental biology, 2014-01, Vol.385 (2), p.279-290

2014

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Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway

Journal of molecular and cellular cardiology, 2010-06, Vol.48 (6), p.1255-1265

2010

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In vivo flow cytometric Pig-a and micronucleus assays: Highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs

Environmental and molecular mutagenesis, 2012-07, Vol.53 (6), p.420-428

2012

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Predicting the Genotoxicity of Polycyclic Aromatic Compounds from Molecular Structure with Different Classifiers

Chemical research in toxicology, 2003-12, Vol.16 (12), p.1567-1580

2003

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Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription

Genetics Research International, 2012-01, Vol.2012 (2012), p.269-280

2012

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Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1860-1864

2007

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Predicting the Genotoxicity of Thiophene Derivatives from Molecular Structure

Chemical research in toxicology, 2003-06, Vol.16 (6), p.721-732

2003

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In silico toxicology protocols

Regulatory toxicology and pharmacology, 2018-07, Vol.96, p.1-17

2018

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Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency

Chemical research in toxicology, 2024-02, Vol.37 (2), p.181-198

2024

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Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines

Regulatory toxicology and pharmacology, 2022-11, Vol.135, p.105247-105247, Article 105247

2022

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Establishing best practise in the application of expert review of mutagenicity under ICH M7

Regulatory toxicology and pharmacology, 2015-10, Vol.73 (1), p.367-377

2015

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Genetic toxicology in silico protocol

Regulatory toxicology and pharmacology, 2019-10, Vol.107, p.104403-104403, Article 104403

2019

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Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses

Regulatory toxicology and pharmacology, 2016-06, Vol.77, p.13-24

2016

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Utility of a next‐generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide

Environmental and molecular mutagenesis, 2021-11, Vol.62 (9), p.512-525

2021

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Probabilistic Neural Network Multiple Classifier System for Predicting the Genotoxicity of Quinolone and Quinoline Derivatives

Chemical research in toxicology, 2005-03, Vol.18 (3), p.428-440

2005

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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective

Regulatory toxicology and pharmacology, 2020-11, Vol.117, p.104746, Article 104746

2020

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International Pig-a gene mutation assay trial (Stage III): Results with N-methyl-N-nitrosourea

Environmental and molecular mutagenesis, 2011-12, Vol.52 (9), p.699-710

2011

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Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses

Regulatory toxicology and pharmacology, 2019-03, Vol.102, p.53-64

2019

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The role of genetic toxicology in drug discovery and optimization

Current drug metabolism, 2008-11, Vol.9 (9), p.978-985

2008

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Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies

Mutation research, 2010-09, Vol.702 (1), p.40-69

2010

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Caenorhabditis elegans Dosage Compensation Regulates Histone H4 Chromatin State on X Chromosomes

Cordon-Bleu Is an Actin Nucleation Factor and Controls Neuronal Morphology

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities

Application of the adverse outcome pathway framework to genotoxic modes of action

The onset of C. elegans dosage compensation is linked to the loss of developmental plasticity

Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway

In vivo flow cytometric Pig-a and micronucleus assays: Highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs

Predicting the Genotoxicity of Polycyclic Aromatic Compounds from Molecular Structure with Different Classifiers

Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription

Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Predicting the Genotoxicity of Thiophene Derivatives from Molecular Structure

In silico toxicology protocols

Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency

Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines

Establishing best practise in the application of expert review of mutagenicity under ICH M7

Genetic toxicology in silico protocol

Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses

Utility of a next‐generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide

Probabilistic Neural Network Multiple Classifier System for Predicting the Genotoxicity of Quinolone and Quinoline Derivatives

Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective

International Pig-a gene mutation assay trial (Stage III): Results with N-methyl-N-nitrosourea

Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses

Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity?

The role of genetic toxicology in drug discovery and optimization

Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies

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