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Synthetic surfactants with SP‐B and SP‐C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases

Journal of internal medicine, 2019-02, Vol.285 (2), p.165-186

2019

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Synthetic surfactant with a recombinant surfactant protein C analogue improves lung function and attenuates inflammation in a model of acute respiratory distress syndrome in adult rabbits

Respiratory research, 2019-11, Vol.20 (1), p.245-245, Article 245

2019

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The proteins of the surfactant system

The European respiratory journal, 1994-02, Vol.7 (2), p.372-391

1994

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Synthetic surfactants

Seminars in fetal & neonatal medicine, 2023-12, Vol.28 (6), p.101503-101503, Article 101503

2023

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Efficient protein production inspired by how spiders make silk

Nature communications, 2017-05, Vol.8 (1), p.15504-15504, Article 15504

2017

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Pilot study of nebulized surfactant therapy for neonatal respiratory distress syndrome

Acta Paediatrica, 2000-04, Vol.89 (4), p.460-464

2000

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Restoration of surfactant activity by polymyxin B in lipopolysaccharide-potentiated injury of immature rabbit lungs

Scientific reports, 2021-01, Vol.11 (1), p.22-22, Article 22

2021

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Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP‑B and SP‑C

ACS chemical biology, 2021-12, Vol.16 (12), p.2864-2873

2021

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Therapeutic effects of exogenous surfactant enriched with dextran in newborn rabbits with respiratory failure induced by airway instillation of albumin

Pulmonary pharmacology & therapeutics, 2008-01, Vol.21 (2), p.393-400

2008

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Acute Effects of a Single Dose of Porcine Surfactant on Patients With the Adult Respiratory Distress Syndrome

Chest, 1994-01, Vol.105 (1), p.195-202

1994

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Biophysical and physiological properties of porcine surfactant enriched with polymyxin B

Biology of the neonate, 2005-01, Vol.88 (2), p.101-108

2005

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The Synthetic Surfactant CHF5633 Restores Lung Function and Lung Architecture in Severe Acute Respiratory Distress Syndrome in Adult Rabbits

Lung, 2024, Vol.202 (3), p.299-315

2024

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Disulphide Bridges in Surfactant Protein B Analogues Affect Their Activity in Synthetic Surfactant Preparations

Neonatology (Basel, Switzerland), 2019-01, Vol.115 (2), p.134-141

2019

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Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome

Translational research : the journal of laboratory and clinical medicine, 2023-12, Vol.262, p.60-74

2023

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Lung recruitment at birth does not improve lung function in immature lambs receiving surfactant

Acta anaesthesiologica Scandinavica, 2001-09, Vol.45 (8), p.986-993

2001

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A Unique Story in Neonatal Research: The Development of a Porcine Surfactant

Neonatology (Basel, Switzerland), 2015-01, Vol.107 (4), p.321-329

2015

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Analyses of Synthetic Surfactant Protein B Analogues

NEONATOLOGY, 2017, Vol.111 (4), p.441

2017

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Efficient delipidation of a recombinant lung surfactant lipopeptide analogue by liquid-gel chromatography

PloS one, 2019-12, Vol.14 (12), p.e0226072-e0226072

2019

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Palmitoylation of a pulmonary surfactant protein C analogue affects the surface associated lipid reservoir and film stability

Biochimica et biophysica acta, 2000-06, Vol.1466 (1), p.169-178

2000

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Pulmonary surfactant‐associated polypeptide C in a mixed organic solvent transforms from a monomeric α‐helical state into insoluble β‐sheet aggregates

Protein science, 1998-12, Vol.7 (12), p.2533-2540

1998

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Synthetic peptide-containing surfactants--evaluation of transmembrane versus amphipathic helices and surfactant protein C poly-valyl to poly-leucyl substitution

European journal of biochemistry, 1998-07, Vol.255 (1), p.116-124

1998

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Impact of synthetic surfactant CHF5633 with SP‐B and SP‐C analogues on lung function and inflammation in rabbit model of acute respiratory distress syndrome

Physiological reports, 2021-01, Vol.9 (1), p.e14700-n/a

2021

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Surface activity of lipid extract surfactant in relation to film area compression and collapse

Journal of applied physiology (1985), 1994-08, Vol.77 (2), p.974

1994

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Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes

PloS one, 2016, Vol.11 (1), p.e0146898-e0146898

2016

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New Generation Synthetic Surfactants

Neonatology (Basel, Switzerland), 2013-01, Vol.103 (4), p.327-330

2013

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Synthetic surfactants with SP‐B and SP‐C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases

Synthetic surfactant with a recombinant surfactant protein C analogue improves lung function and attenuates inflammation in a model of acute respiratory distress syndrome in adult rabbits

The proteins of the surfactant system

Synthetic surfactants

Efficient protein production inspired by how spiders make silk

Pilot study of nebulized surfactant therapy for neonatal respiratory distress syndrome

Restoration of surfactant activity by polymyxin B in lipopolysaccharide-potentiated injury of immature rabbit lungs

Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP‑B and SP‑C

Therapeutic effects of exogenous surfactant enriched with dextran in newborn rabbits with respiratory failure induced by airway instillation of albumin

Acute Effects of a Single Dose of Porcine Surfactant on Patients With the Adult Respiratory Distress Syndrome

Biophysical and physiological properties of porcine surfactant enriched with polymyxin B

The Synthetic Surfactant CHF5633 Restores Lung Function and Lung Architecture in Severe Acute Respiratory Distress Syndrome in Adult Rabbits

Disulphide Bridges in Surfactant Protein B Analogues Affect Their Activity in Synthetic Surfactant Preparations

Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome

Lung recruitment at birth does not improve lung function in immature lambs receiving surfactant

A Unique Story in Neonatal Research: The Development of a Porcine Surfactant

Analyses of Synthetic Surfactant Protein B Analogues

Efficient delipidation of a recombinant lung surfactant lipopeptide analogue by liquid-gel chromatography

Palmitoylation of a pulmonary surfactant protein C analogue affects the surface associated lipid reservoir and film stability

Pulmonary surfactant‐associated polypeptide C in a mixed organic solvent transforms from a monomeric α‐helical state into insoluble β‐sheet aggregates

Synthetic peptide-containing surfactants--evaluation of transmembrane versus amphipathic helices and surfactant protein C poly-valyl to poly-leucyl substitution

Impact of synthetic surfactant CHF5633 with SP‐B and SP‐C analogues on lung function and inflammation in rabbit model of acute respiratory distress syndrome

Surface activity of lipid extract surfactant in relation to film area compression and collapse

Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes

New Generation Synthetic Surfactants

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