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Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

The FASEB journal, 2017-01, Vol.31 (1), p.5-10

2017

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Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

Cell chemical biology, 2020-12, Vol.27 (12), p.1456-1471

2020

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CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease

Redox biology, 2020-09, Vol.36, p.101648-101648, Article 101648

2020

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Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

The FASEB journal, 2017-01, Vol.31 (1), p.5-10

2017

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Elevating acetyl-CoA levels reduces aspects of brain aging

eLife, 2019-11, Vol.8

2019

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Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse

The journals of gerontology. Series A, Biological sciences and medical sciences, 2018-03, Vol.73 (3), p.299-307

2018

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Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis

Free radical biology & medicine, 2021-08, Vol.171, p.219-231

2021

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Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Pharmacology & therapeutics (Oxford), 2021-05, Vol.221, p.107749-107749, Article 107749

2021

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Functional Consequences of Age-Dependent Changes in Glutathione Status in the Brain

Antioxidants & redox signaling, 2013-09, Vol.19 (8), p.813-822

2013

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Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

Redox biology, 2019-02, Vol.21, p.101089-101089, Article 101089

2019

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Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice

Aging cell, 2014-04, Vol.13 (2), p.379-390

2014

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Geroneuroprotectors: Effective Geroprotectors for the Brain

Trends in pharmacological sciences (Regular ed.), 2018-12, Vol.39 (12), p.1004-1007

2018

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Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

Cell death & disease, 2020-10, Vol.11 (10), p.828, Article 828

2020

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The mitochondrial ATP synthase is a shared drug target for aging and dementia

Aging cell, 2018-04, Vol.17 (2), p.n/a

2018

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Ageing and inflammation – A central role for mitochondria in brain health and disease

Ageing research reviews, 2015-05, Vol.21, p.30-42

Currais, Antonio

2015

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The Alzheimer’s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver

Biomedicine & pharmacotherapy, 2022-03, Vol.147, p.112648-112648, Article 112648

2022

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SUMMER, a shiny utility for metabolomics and multiomics exploratory research

Metabolomics, 2020-12, Vol.16 (12), p.126-126, Article 126

2020

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The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice

International journal of molecular sciences, 2023-04, Vol.24 (7), p.6828

2023

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The Neuroprotective Flavonoids Sterubin and Fisetin Maintain Mitochondrial Health under Oxytotic/Ferroptotic Stress and Improve Bioenergetic Efficiency in HT22 Neuronal Cells

Antioxidants, 2024-04, Vol.13 (4), p.460

2024

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The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer's Disease, a Case Made With the Genus Eriodictyon

Frontiers in pharmacology, 2020-03, Vol.11, p.208-208

2020

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A chemical biology approach to identifying molecular pathways associated with aging

GeroScience, 2021-02, Vol.43 (1), p.353-365

2021

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Diabetes exacerbates amyloid and neurovascular pathology in aging‐accelerated mice

Aging cell, 2012-12, Vol.11 (6), p.1017-1026

2012

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A comprehensive multiomics approach toward understanding the relationship between aging and dementia

Aging (Albany, NY.), 2015-11, Vol.7 (11), p.937-955

2015

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Functional consequences of age-dependent changes in glutathione status in the brain

Antioxidants & redox signaling, 2013-09, Vol.19 (8), p.813

2013

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The Origin of Life at the Origin of Ageing?

Ageing research reviews, 2017-05, Vol.35, p.297-300

Currais, Antonio

2017

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Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease

Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

Elevating acetyl-CoA levels reduces aspects of brain aging

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse

Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Functional Consequences of Age-Dependent Changes in Glutathione Status in the Brain

Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice

Geroneuroprotectors: Effective Geroprotectors for the Brain

Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

The mitochondrial ATP synthase is a shared drug target for aging and dementia

Ageing and inflammation – A central role for mitochondria in brain health and disease

The Alzheimer’s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver

SUMMER, a shiny utility for metabolomics and multiomics exploratory research

The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice

The Neuroprotective Flavonoids Sterubin and Fisetin Maintain Mitochondrial Health under Oxytotic/Ferroptotic Stress and Improve Bioenergetic Efficiency in HT22 Neuronal Cells

The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer's Disease, a Case Made With the Genus Eriodictyon

A chemical biology approach to identifying molecular pathways associated with aging

Diabetes exacerbates amyloid and neurovascular pathology in aging‐accelerated mice

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

Functional consequences of age-dependent changes in glutathione status in the brain

The Origin of Life at the Origin of Ageing?

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